Application of metal fullerene monocrystal nanoparticles in preparation of specific tumor vascular disrupting agent

A fullerene single crystal and metal fullerene technology, which is applied in the field of medicine, can solve the problems of restricting widespread use, and achieve the effect of efficiently scavenging free radicals, protecting normal cells, and avoiding damage

Active Publication Date: 2014-11-05
赤峰福纳康生物技术有限公司 +1
View PDF4 Cites 29 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the clinical trials of small molecule VDAs currently developed all reported cardiovascular adverse reactions such as hypertension,

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of metal fullerene monocrystal nanoparticles in preparation of specific tumor vascular disrupting agent
  • Application of metal fullerene monocrystal nanoparticles in preparation of specific tumor vascular disrupting agent
  • Application of metal fullerene monocrystal nanoparticles in preparation of specific tumor vascular disrupting agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] Example 1: Water-soluble GdC 82 Bubble generation experiment of single crystal nanoparticles under the action of radio frequency

[0068] Such as image 3 Shown, water-soluble GdC 82It was observed that a large number of bubbles were continuously generated in the solution during the radio frequency action (under 13.5MHz radio frequency irradiation) of single crystal nanoparticles. This is because the water-soluble GdC 82 Under the action of radio frequency, single crystal nanoparticles accumulate energy internally. When the accumulated temperature exceeds the phase transition temperature point (40-90°C) of the material, the volume of the material expands rapidly and generates bubbles.

Embodiment 2

[0069] Example 2: Water-soluble GdC 82 Tumor therapy and effect verification of single crystal nanoparticles under radiofrequency action

[0070] 1) Establish an animal model of tumor-bearing mice:

[0071] Extract ascites from mice inoculated with H22 liver cancer cell line in the peritoneal cavity, centrifuge to remove the supernatant, and count the inoculated cells at a concentration of 10 7 50 μL of the cell suspension / mL was subcutaneously placed on the right thigh of each mouse. After 5-7 days of growth, the tumor size is about 5 mm for experiments.

[0072] 2) Animal experiments in vivo magnetic resonance imaging and tumor treatment experiments:

[0073] Injection of water-soluble GdC via the tail vein 82 150 μL of single crystal nanoparticle aqueous solution (concentration: 10 mmol / L) was placed in tumor-bearing mice. RF pulses were applied under a magnetic field for 1h (temperature 37°C, frequency 200MHz, bandwidth 500kHz), and tumor tissues, kidneys, and Imagin...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Particle sizeaaaaaaaaaa
Login to view more

Abstract

The invention discloses an application of metal fullerene monocrystal nanoparticles in preparation of a tumor vascular disrupting agent. The monocrystal nanoparticles are water-soluble metal fullerene nanoparticles with the surface charged with negative electricity, and have the particle size range of 50-250 nm; the nanomaterial can absorb and convert outside world radiation energy into heat energy, and the volume is expanded sharply when a temperature reaches a phase transition point. During treatment, a tumor-carried living organism is injected and given with the metal fullerene monocrystal nanoparticles; the metal fullerene monocrystal nanoparticles reach a tumor part through blood circulation, and are stranded at tumor pores and defective parts; under the action of the outside world radiation energy, the metal fullerene monocrystal nanoparticles accumulate heat, the temperature rises, and the volume is expanded sharply when the temperature exceeds the phase transformation critical point, so that morphological structures or functions of tumor vascular endothelial cells are changed, and tumor vessels are interdicted so as to make the tumor cells starved to death.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of metal fullerene single crystal nanoparticles in tumor blood vessel blocking agents. Background technique [0002] In recent years, the morbidity and mortality of cancer have been on the rise. There are as many as 15 million new cancer patients in the world every year, which seriously threatens human health. The traditional three major tumor treatment methods, namely surgery, radiotherapy and chemotherapy, all have some limitations, causing cancer to become one of the leading causes of human death. In recent years, with the development of science and technology, some emerging physical, chemical and biological methods have emerged to treat tumors, such as hyperthermia, radiofrequency ablation therapy, photodynamic therapy and immunotherapy. [0003] In 1971, Folkman et al. proposed that the growth and metastasis of solid tumors depend on tumor angiogenesis, a...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K41/00A61P35/00
Inventor 王春儒甄明明舒春英王太山李杰张国强
Owner 赤峰福纳康生物技术有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap