Hollow MnO2 composite nanomaterial, preparation method and application thereof

Abstract

The invention provides a hollow manganese dioxide (MnO2) composite nanomaterial, a preparation method and application thereof. The method comprises the steps that manganese dioxide is dissolved into an ethyl alcohol and basic solution mixed solution, and hydrolysis is performed to obtain silicon dioxide nano-particles; a water solution of the silicon dioxide nano-particles is mixed with a potassium permanganate solution, a reduction reaction is performed, etching is performed, and hollow MnO2 nano-particles are obtained; the surfaces of the hollow MnO2 nano-particles are modified by a Polypropylene amine hydrochloride layer, a polyacrylic acid layer and an aminated polyethylene glycol layer in sequence, and the hollow MnO2 composite nanomaterial is obtained. According to the method, a large number of MnO2 composite nano-materials with the controllable morphology and hollow structures can be obtained through one experiment, and the repeatability is good; the good water solubility and biocompatibility are achieved, drugs are efficiently loaded and released particularly at a tumor site; the MnO2 composite nanomaterial is combined with anti-PD-L1 for use, original tumors can be efficiently killed, and growth far-end tumors can be obviously restrained.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a hollow MnO 2 Composite nanomaterials, their preparation methods and their applications. Background technique [0002] Cancer is one of the major malignant diseases that threaten human health. Although a large amount of human, material and financial resources have been invested in the prevention and treatment of cancer for decades since the 1950s, the progress made by human beings in this regard is very limited. [0003] In recent years, manganese dioxide (MnO 2 ) nanostructures have attracted considerable attention as a class of tumor microenvironment (TME)-responsive theranostics. The study found that MnO 2 The H present in the TME of the nanostructure + Or glutathione (GSH) can be decomposed under the condition of Mn produced 2+ The ions significantly enhance T1 magnetic resonance imaging, which can be used for tumor-specific imaging and detection. At the same time...

AI Technical Summary

Problems solved by technology

The previously reported MnO 2 Nanostructures are mostly nanoparticles, nanosheets or nanocomposites combined with nanomaterials, which cannot achieve effective drug loading and precise control of drug release

[0004] Currently, there have been reports in the literature based on MnO 2 The nanocomposite is used for the treatment of cancer, but it has the following disadvantages: (1) the synthesis steps are relatively complicated, and it is difficult to carry out large-scale synthesis

(2) Synthetic MnO 2 The shape of the material is uncontrollable, which is not conducive to the repetition of experiments

(3) Synthetic MnO 2 Most of the materials are compounded with other inorganic materials, which is not conducive to the metabolism of materials out of the body

However, it has not been reported to prepare a synthetic method that is simple, can be produced in large quantities, has good reproducibility, is easy to metabolize, and uses the particle to prepare imaging diagnostic and therapeutic agents for cancer at the same time.

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