The invention discloses an interference management self optimization method based on non-orthogonal multiple access, and belongs to the field of wireless network. The method comprises the following steps: firstly, in a super dense scene, for a fixed sub-bandwidth, each small base station separately calculates a signal to noise ratio to a respective request user, deletes the adjacent interference base stations of the present base station according to the sensed interference signal intensity of the adjacent base stations, and independently constructs a dynamic local interference map; then, each small base station independently accomplish resource allocation by comprehensively considering the communication demand and the information of the local interference map, in order to reduce the interface among the networks, the interference optimization problem is modeled as a game problem based on satisfaction, a resource allocation result is obtained by using a distributed algorithm, each small base station reasonably allocates different power and sub-bandwidths to respective request users, so that the system interference is maximized. By adoption of the interference management self optimization method, the network interference is reduced, ensures the communication needs of the user is ensured, and the convergence is good.