The invention belongs to the field of mineral exploration, and aims at solving the problems that the physical heterogeneity of sand bodies in sandstone-type uranium ore stratums in a research area ishigh, and conventional hole-permeability fitting formula accounts for low permeability. The method for calculating the permeability of the sandstone-type uranium ore sand body based on the flow unit classification is provided, and the stratum permeability explanation precision is improved. The method comprises the following steps: 1, calculating a flow unit index of a sample point according to actually measured physical property data of a core of a coring well section; Step 2, realizing reservoir classification by applying a probability graph method; Step 3, establishing a quantitative relation between the flow unit index and the logging response based on five logging curve data of quantitative gamma, natural gamma, density, apparent resistivity and sonic time difference; Step 4, on the basis of flow unit index classification, respectively establishing holes according to different types of reservoirs; a seepage relational expression; Step 5, performing reservoir classification; 6, obtaining a stratum interpretation permeability value; and step 7, drawing a permeability spatial distribution diagram, and establishing an ore searching model.