Manufacturing a gamma radiation source includes providing an unacceptable material that is a combination of acceptable and unacceptable isotopes, transforming the unacceptable material into an acceptable material by removing unacceptable isotopes from the unacceptable material, leaving only acceptable isotopes, mixing selenium-74 and the acceptable material and heating the mixture to cause the constituents to inter-react and subsequently subjecting the reaction product to irradiation to convert at least a proportion of the selenium-74 to selenium-75. Manufacturing a gamma radiation source may also include adding at least one other acceptable material to the mixture. The at least one other acceptable material may be added to the mixture prior to heating the mixture. The unacceptable material may be selected from the group consisting of: Zinc, Titanium, Nickel, Zirconium, Ruthenium, Iron, Silver, Indium, Thallium, Samarium, Ytterbium, Germanium, and Iridium.