The invention relates to the field of environmental protection, in particular to an in-situ soil and underground water integrated remediation system and remediation method. The system comprises an extraction-injection system, an ozone generation system, a wastewater treatment system, a waste gas treatment system and a hydrogen peroxide configuration system. The extraction-injection system, the ozone generation system, the wastewater treatment system, the waste gas treatment system and the hydrogen peroxide configuration system are connected through corresponding pipelines and are equipped withcorresponding liquid flow meters and gas flow meters. According to the method, through combination with the advantages of extraction-treatment, extraction-injection integration, an underwater circulating well, gas-liquid pollutant treatment, ozone-hydrogen peroxide combined oxidation and in-situ oxidation, polluted underground water is extracted and then is subjected to oxidation treatment through ozone and hydrogen peroxide; and then the treated water containing the ozone and hydrogen peroxide is injected underground to conduct in-situ oxidation remediation. By means of the method, organic polluted soil and underwater can be restored simultaneously. Moreover, the remediation range is wide, the remediation period is short, the cost is low, and operation is convenient.