The invention relates to a large-thickness structural steel plate for a high-rise building and further relates to a production method of the steel plate at the same time. The steel plate is formed by melting the following component percentages by weight: 0.16-0.19% of C, not more than 0.55% of Si, 1.40-1.55% of Mn, not more than 0.012% of P, not more than 0.003% of S, 0.020-0.050% of TAl (total aluminum), 0.020-0.30% of Nb, 0.035-0.050% of V, not more than 0.30% of Ni, not more than 0.30% of Cr, not more than 0.05% of Ti, and the balance of Fe and inevitable impurities. The production method comprises the steps as follows: smelting; refining; continuously casting; stacking; heating; rolling; stacking and slowly cooling; detecting defects; normalizing; and obtaining the finished steel plate. The shop sign of the steel plate is Q390GJC / Z35, the delivery state of the steel plate is normalization, continuous casting blanks with cross sections of 330 mm * 2400 mm are adopted to form the steel plate, the maximum thickness of the steel plate is 120 mm, and the requirements of the level II in the JB / T4730.3-2005 detection standard are met; and the steel plate has the characteristics of capability of being formed by the continuous casting blanks, larger thickness, higher strength and toughness, good lamellar tearing resistance and the like, and is suitable for manufacturing structural members for the high-rise building.