Cefixime dispersing tablet and preparation methods thereof

A technology of cefixime and dispersible tablets, which is applied in the field of cefixime dispersible tablets and its industrialized preparation, can solve the problems of short disintegration time and dissolution performance, and achieve the effects of healthy and clean production environment, cost reduction and good prescription

Active Publication Date: 2009-12-23
GUANGZHOU BAIYUNSHAN PHARMA HLDG CO LTD BAIYUNSHAN PHARMA GENERAL FACTORY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The purpose of the present invention is to provide a kind of cefixime dispersible tablet and preparation method thereof, the technical problem to be solved in the present invention is to make cefixime preparati

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0086] Example 1

[0087] (a) Weigh 250 g of cefixime, 50 g of starch, 60 g of mannitol, 60 g of microcrystalline cellulose, and 12 g of sodium starch glycolate, sieving, and mixing uniformly to obtain a mixed powder;

[0088] (b) Add povidone K304g and steviol 0.1g to the 60% ethanol solution, adjust the amount of 60% ethanol to obtain 86.4g of the binder solution, add the binder solution to the above mixed powder, and use Shanghai Xinyi Pharmaceutical KJZ-10 type rapid stirring granulation machine made by the equipment company;

[0089] (c) Adjust the inlet temperature of the DLB-3 multifunctional granulating and coating machine (Chongqing Guangsha) to 70°C, and the material temperature to 50°C, and fluidize and dry the granules for 2 minutes;

[0090] (d) Take the dried granules, add the remaining 48 g of sodium starch glycolate, 0.5 g of orange flavor, and 4.8 g of magnesium stearate after the whole granules, and mix them evenly;

[0091] (e) Use a rotary tablet press to compr...

Example Embodiment

[0093] Example 2

[0094] (a) Weigh 120 g of cefixime, 70 g of starch, 30 g of mannitol, and 10 g of sodium starch glycolate, sieving, and mixing uniformly to obtain a mixed powder;

[0095] (b) Add 303.6g of povidone K and 0.3g of steviol in 50% ethanol solution, adjust the amount of 50% ethanol to obtain 69g of adhesive solution, add the adhesive solution to the above mixed powder, and use Shanghai Xinyi KJZ-10 rapid stirring granulation machine made by Pharmaceutical Equipment Company;

[0096] (c) Adjust the inlet air temperature of the DLB-3 multifunctional granulating and coating machine (Chongqing Guangsha) to 60°C and the material temperature to 40°C, and fluidize the granules for 6 minutes;

[0097] (d) Take the dried granules, add the remaining 10 g of sodium starch glycolate, 1.5 g of orange flavor, and 2.5 g of magnesium stearate after the whole granules, and mix well;

[0098] (e) Compress the tablet with a rotary tablet press to make 1000 tablets.

[0099] The hardness...

Example Embodiment

[0100] Example 3

[0101] (a) Weigh 30g of starch, 35g of mannitol, 35g of microcrystalline cellulose, and 11g of sodium starch glycolate, sieving, and mixing uniformly to obtain a mixed powder;

[0102] (b) Add povidone K304g and steviol 0.4g to the 40% ethanol solution, adjust the amount of 40% ethanol to obtain 22.5g of the binder solution, add the binder solution to the above mixed powder, and use Shanghai Xinyi Pharmaceutical The KJZ-10 fast-mixing granulation mechanism soft material manufactured by the equipment company uses the DGN multifunctional medicinal test mechanism granules produced by Shanghai Yali Pharmaceutical Machinery Co., Ltd.;

[0103] (c) Adjust the inlet air temperature of the DLB-3 multifunctional granulating and coating machine (Chongqing Guangsha) to 60°C and the material temperature to 40°C, and fluidize the granules for 6 minutes;

[0104] (d) Take the dried granules, add 65 g of cefixime, 11 g of the remaining sodium starch glycolate, 1.8 g of orange ...

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Abstract

The invention discloses a cefixime dispersing tablet and preparation methods thereof, belonging to the technical field of pharmaceutical preparation. The cefixime dispersing tablet comprises 40-420 mg of cefixime, 0-100 mg of starch, 0-250 mg of amylum pregelatinisatum, 10-80 mg of mannite, 0-150 mg of microcrystalline cellulose, 10-60 mg of carboxyrnethyl starch sodium, 2-20 mg of polyvidone K30, 0.4-10 mg of magnesium stearate, 0-10 mg of Steviosin and 0-10 mg of orange compound perfume. The preparation method comprises the following steps: evenly mixing basic remedies and excipients; adding adhesive to prepare granulates; drying; sorting and then adding with other excipients; and tabletting. The other preparation method is described as follows: the basic remedies are added after granulating. The invention aims to solve the technical problem that cefixime preparation has shorter disintegration time, better leachability, higher content of the basic remedies, production cost reduction, quality detection time reduction and production environment pollution reduction.

Description

technical field [0001] The invention relates to a medicine and a preparation method thereof, in particular to a cefixime dispersible tablet and an industrializable preparation method thereof. Background technique [0002] Cefixime (Cefixime) is a third-generation oral cephalosporin developed in Japan, which produces a bactericidal effect mainly by destroying the synthesis of bacterial cell walls. Cefixime has a wide range of antibacterial effects on Gram-positive bacteria and Gram-negative bacteria, and its antibacterial activity against Haemophilus influenzae and N. The protective effect of Serratia japonicus on lethal infection in mice is significantly better than other oral cephalosporin antibiotics; cefixime is stable to β-lactamase, has a long-lasting plasma concentration and long plasma half-life, so cefixime can be used daily Take 1-2 times, easy to take; cefixime is effective when taken orally, tasteless and odorless, and has a high concentration in lung, gallbladde...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/546A61K47/38A61P31/04
Inventor 卢丹吴振华朱少璇尤孝庆
Owner GUANGZHOU BAIYUNSHAN PHARMA HLDG CO LTD BAIYUNSHAN PHARMA GENERAL FACTORY
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