Cefixime dispersing tablet and preparation methods thereof
A technology of cefixime and dispersible tablets, which is applied in the field of cefixime dispersible tablets and its industrialized preparation, can solve the problems of short disintegration time and dissolution performance, and achieve the effects of healthy and clean production environment, cost reduction and good prescription
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[0086] Example 1
[0087] (a) Weigh 250 g of cefixime, 50 g of starch, 60 g of mannitol, 60 g of microcrystalline cellulose, and 12 g of sodium starch glycolate, sieving, and mixing uniformly to obtain a mixed powder;
[0088] (b) Add povidone K304g and steviol 0.1g to the 60% ethanol solution, adjust the amount of 60% ethanol to obtain 86.4g of the binder solution, add the binder solution to the above mixed powder, and use Shanghai Xinyi Pharmaceutical KJZ-10 type rapid stirring granulation machine made by the equipment company;
[0089] (c) Adjust the inlet temperature of the DLB-3 multifunctional granulating and coating machine (Chongqing Guangsha) to 70°C, and the material temperature to 50°C, and fluidize and dry the granules for 2 minutes;
[0090] (d) Take the dried granules, add the remaining 48 g of sodium starch glycolate, 0.5 g of orange flavor, and 4.8 g of magnesium stearate after the whole granules, and mix them evenly;
[0091] (e) Use a rotary tablet press to compr...
Example Embodiment
[0093] Example 2
[0094] (a) Weigh 120 g of cefixime, 70 g of starch, 30 g of mannitol, and 10 g of sodium starch glycolate, sieving, and mixing uniformly to obtain a mixed powder;
[0095] (b) Add 303.6g of povidone K and 0.3g of steviol in 50% ethanol solution, adjust the amount of 50% ethanol to obtain 69g of adhesive solution, add the adhesive solution to the above mixed powder, and use Shanghai Xinyi KJZ-10 rapid stirring granulation machine made by Pharmaceutical Equipment Company;
[0096] (c) Adjust the inlet air temperature of the DLB-3 multifunctional granulating and coating machine (Chongqing Guangsha) to 60°C and the material temperature to 40°C, and fluidize the granules for 6 minutes;
[0097] (d) Take the dried granules, add the remaining 10 g of sodium starch glycolate, 1.5 g of orange flavor, and 2.5 g of magnesium stearate after the whole granules, and mix well;
[0098] (e) Compress the tablet with a rotary tablet press to make 1000 tablets.
[0099] The hardness...
Example Embodiment
[0100] Example 3
[0101] (a) Weigh 30g of starch, 35g of mannitol, 35g of microcrystalline cellulose, and 11g of sodium starch glycolate, sieving, and mixing uniformly to obtain a mixed powder;
[0102] (b) Add povidone K304g and steviol 0.4g to the 40% ethanol solution, adjust the amount of 40% ethanol to obtain 22.5g of the binder solution, add the binder solution to the above mixed powder, and use Shanghai Xinyi Pharmaceutical The KJZ-10 fast-mixing granulation mechanism soft material manufactured by the equipment company uses the DGN multifunctional medicinal test mechanism granules produced by Shanghai Yali Pharmaceutical Machinery Co., Ltd.;
[0103] (c) Adjust the inlet air temperature of the DLB-3 multifunctional granulating and coating machine (Chongqing Guangsha) to 60°C and the material temperature to 40°C, and fluidize the granules for 6 minutes;
[0104] (d) Take the dried granules, add 65 g of cefixime, 11 g of the remaining sodium starch glycolate, 1.8 g of orange ...
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