70 results about "Nitrogenous base" patented technology

A compound of a general structure:wherein:B is selected from the group consisting of derivatives of naturally occurring nitrogenous bases having a C-H group at positions 5 or 8, and derivatives of nitrogenous base-analogs having a C-H group at positions 5 or 8;D is at least one derivatizing group, including hydrogen; andM is a maleimide derivative.

Energetic materials, such as nitrocellulose, TNT, RDX, and combinations thereof, optionally in combination with chemical warfare agents, such as mustard gas, Lewisite, Tabun, Sarin, Toman, VX, and combinations thereof, are destroyed when chemically reacted according to the method of the invention. The method comprises reacting the energetic materials and chemical warfare agents, of present, with solvated electrons which are preferably produced by dissolving an active metal such as sodium in a nitrogenous base such as anhydrous liquid ammonia.

Compositions comprising an alkanesulfonic acid and an organic nitrogenous base, and related methods of use.

A modified nucleoside analogue having the formula (I): P-S-B-L-R where: P is a 5′ triphosphate or analogue or derivative thereof; S is a substituted or unsubstituted five- or six-membered sugar, sugar analogue or acyclo sugar analogue, but excluding a dideoxy-sugar, B is a substituted or unsubstituted nitrogenous base or base analogue or derivative thereof; L is a linker group; and R is a substituted or unsubstituted metallocene moiety or substituted or unsubstituted metal complex or substituted or unsubstituted redox-active organic moiety. The modified nucleoside is capable of enzymatic incorporation into a nucleotide chain and allows for redox labelling of nucleotides.

The invention relates to a polypeptide nano-micelle for treatment of cancers. The polypeptide in the invention can inhibit cancer metastasis; the polypeptide nano-micelle is formed by self-assembling of pegylated phosphatide (PEG-PE) and the polypeptide; and the pegylated phosphatide is a compound formed by combination of polyethylene glycol with nitrogenous bases on phosphatide molecules through covalent bonds. Specifically, the invention relates to a method for improving biostability of the polypeptide through PEG-PE micelles and provides a preparation method for the polypeptide-PEG-PE nano-micelle and application of the polypeptide-PEG-PE nano-micelle in inhibition of cancer metastasis. The nano-micelle formed by PEG-PE and the polypeptide has good stability in a salt solution, and presents the stronger characteristic of inhibiting migration and infiltration of cancer cells. The polypeptide-PEG-PE nano-micelle provided by the invention provides a feasible method and technology for cancer metastasis inhibition and cancer treatment.

Ionic liquids containing a cation with a potentially nucleophilic carbon atom bearing a relatively acidic hydrogen atom bonded to a potentially nucleophilic carbon atom, typically in the conjugated —NC(H)N— structure or a —NC(H)S— structure of imidazolium, imidazolidinium or thiazolium salts, can be capable of acting as sorbents for CO₂ in cyclic separation processes. The ionic liquid may be used on its own, mixed with a solvent, preferably an aprotic, polar, non-aqueous solvent such as toluene, DMSO, NMP or sulfolane, or in conjunction with a non-nucleophilic nitrogenous base promoter compound having a pK_a of at least 10.0 such as a carboxamidine or a guanidine.

The invention discloses a method for preparing a nitrogen-producing carbon molecular sieve, which comprises the following steps: a. material proportion; b. fine pulverizing; c. extruding and moulding; d. high-temperature nitrogenous-base carbonizing; e. and high-temperature nitrogenous-base pore-forming treatment. Since the material selection, the material proportioning, the process parameter combination and the like of the invention are repeatedly tested, compared, concluded and summarized by the applicant, although the production method is not changed greatly, the obtained nitrogen-producing carbon molecular sieve has very prominent effect and has superior performance in several aspects such as the concentration of the produced nitrogen, the nitrogen yield, the recovery rate, the compressive strength and the like.

The present invention concerns oligonucleotides containing one or more modified nucleotides which increase the binding affinity of the oligonucleotides to target nucleic acids having a complementary nucleotide base sequence. These modified oligonucleotides hybridize to the target sequence at a faster rate than unmodified oligonucleotides having an identical nucleotide base sequence. Such modified oligonucleotides include oligonucleotides containing at least one 2′-O-methylribofuranosyl moiety joined to a nitrogenous base. Oligonucleotides can be modified in accordance with the present invention to preferentially bind RNA targets. The present invention also concerns methods of using these modified oligonucleotides and kits containing the same.

The invention discloses a biology base air source and a flame retardant polyolefin compound formed by the biology base air source. The biology base air source is nitrogenous base subjected to surface treatment by a coupling agent, wherein the nitrogenous base includes A, G, T, C, U and A-T, G-C and A-U. The flame retardant polyolefin compound comprises polyolefin, a flame retardant, a synergist, a lubricant and an antioxidant; the a flame retardant is formed by mixing an acid source, a carbon source and the biology base air source. The flame retardant polyolefin compound has the following characteristics that the flame retardant effect is good; the addition quantity of the flame retardant is small; the efficiency is high; the cost is low; the advantages of good mechanical property and light weight of polyolefin are maintained; the product heat stability is good; the flame retardant and the synergist are matched with polyolefin processing and pyrolysis temperature; no decomposition or equipment corrosion exists in the processing process; the acid source, the carbon source and the air source achieve a synergistic effect; after the combustion, a compact expansion carbon layer is formed to protect a lower layer base body; the flame retardant performance of the compound is obviously improved; the compound can pass through UL94V-0 level; melting dripping resistant performance is realized.

A solvent system comprising an ionic Liquid formed from a relatively acidic component and a nitrogenous base for the removal of acid gases from mixed gas streams is provided. Also provided is a process for removing acid gases from mixed gas streams using the disclosed solvent system. The solvent system may be utilized within a gas processing system.

Provided herein are methods and compositions for expression of a nucleic acid construct comprising nucleic acids encoding a) a recombinant polypeptide, and b) a prototrophy-restoring enzyme in a host cell that is auxotrophic for at least one metabolite. In various embodiments, the host cell is auxotrophic for a nitrogenous base compound or an amino acid. The invention involves introducing an analogue into the growth media for the host cell such that the analogue is incorporated into the recombinant polypeptide or a nucleic acid coding sequence thereof. In various embodiments, the compositions and methods disclosed herein result in improved recombinant protein expression compared to expression of recombinant protein in an antibiotic selection system, or compared to expression of the recombinant protein in an expression system that lacks a metabolite analogue.

Tetrafluoroboric acid and an organic nitrogenous base, related compounds and compositions, as can be used in conjunction with various methods of cleaning and/or the treatment of substrate surfaces.

The present invention provides a 3-phenylisoserine derivative production method for obtaining 3-phenylisoserine derivatives represented by formula (2) (in the formula, R1 represents a phenyl group or a phenyl group having a substituent group; R3 represents a hydrogen atom, a methyl group, a benzyl group, a p-methoxybenzyl group, a tert-butly group, a methoxymethyl group, a 2-tetrahydropyranyl group, an ethoxyethyl group, an acetyl group, a pivoloyl group, a benzoyl group, a trimethylsilyl group, a triethylsilyl group, or a tert-butyldimethylsilyl group; R4 represents a formyl group, an acetyl group, a benzoyl group, a tert-butoxycarbonyl group, or a benzyloxycarbonyl group; and R5 represents a C1-4 alkyl group) by protecting, in water or a mixed solvent containing water, the amino group of a compound represented by formula (1) (in the formula, R1 represents a phenyl group or a phenyl group having a substituent group; R2 represents an alkali metal, an alkaline earth metal, or a nitrogenous base; and R3 represents a hydrogen atom, a methly group, a benzyl group, a p-methoxybenzyl group, a tert-butyl group, a methoxymethyl group, a 2-tetrahydropyranyl group, an ethoxymethly group, an acetyl group, a pivoloyl group, a benzoyl group, a trimethylsilyl group, a triethylsilyl group, or a tert-butyldimethylsilyl group), and when a specific compound has been obtained, extracting the compound using a C4 ether solvent, and while removing the C4 ether solvent and moisture content, replacing at least some of the C4 ether solvent with a C1-4 aliphatic alcohol and implementing an esterification reaction, and then isolating the 3-phenylisoserine derivative at 0-30 DEG C. The 3-phenylisoserine derivative production method enables the production of 3-phenylisoserine derivatives having at least 99% purity.

A method is used to prepare silver nanoparticles or copper nanoparticles in the form of a silver nanoparticle cellulosic polymeric composite or a copper nanoparticle cellulose polymeric composite, respectively. A cellulosic polymer, organic solvent having a boiling point at atmospheric pressure of 100° C. to 500° C. and a Hansen parameter (δ_T^Polymer) equal to or greater than that of the cellulosic polymer, ascorbic acid, and a nitrogenous base are mixed to form a premix solution. At room temperature or upon heating the premix solution to a temperature of at least 40° C., a solution of reducible silver ions or reducible copper ions is added. The resulting silver or copper nanoparticle composite is cooled, isolated, and re-dispersed in an organic solvent, providing a non-aqueous silver-containing or copper-containing dispersion that can be disposed on a substrate to form an article.