Enhancing transdermal administration of hydrophilic drugs

A drug, hydrophilic technology, used in drug combination, drug delivery, antipyretics, etc., can solve problems such as sensitization, skin irritation, etc.
CN1886105AInactive Publication Date: 2006-12-27DERMATRENDS INC
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
DERMATRENDS INC
Publication Date
2006-12-27
Estimated Expiration
Not applicable · inactive patent

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Abstract

Methods, formulations, and drug delivery systems are provided for enhancing the flux of a transdermally administered hydrophilic drug using a basic permeation enhancer composition. The enhancer composition contains an inorganic hydroxide and a weaker, nitrogenous base, wherein the bases are selected such that a 0.1M aqueous solution of the nitrogenous base has a pH that is about 1.0 to about 6.5 lower than the pH of a 0.1M aqueous solution of the inorganic hydroxide. Additionally, the molar ratio of the nitrogenous base to the inorganic hydroxide in the enhancer composition is in the range of about 0.5n:1 to about 20n:1, where n is the number of hydroxide ions per molecule of the inorganic hydroxide.
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Description

technical field

[0001] The present invention relates generally to topical and transdermal administration of pharmacologically active drugs, and more particularly to methods and compositions for enhancing the flux of hydrophilic drugs across body surfaces using alkaline permeation enhancer compositions. Background technique

[0002] The way of drug delivery through the skin has many advantages: First, it is comfortable, convenient and non-invasive. The variability in absorption and metabolism rates encountered in oral therapy is avoided, as are other inherent nuisances such as gastrointestinal irritation and the like. Transdermal drug delivery also enables a high degree of control over the blood concentration of any particular drug.

[0003] The skin is a structurally complex and relatively thick membrane. Molecules that move into and through intact skin from the environment must first penetrate the stratum corneum and whatever is on its surface. They must then pass throug...

Claims

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