5 results about "Diffusion cell" patented technology

The application discloses a kind of calcitriol soft capsule content in vitro evaluation method and its application, belong to the technical field of pharmaceutical analysis.The method uses diffusion cell device, under certain conditions, the dissolution and penetration behavior of calcitriol soft capsule content is simulated and determined.Specifically, acidic or buffered salt medium solution containing specific proportion alcohol is added to diffusion cell, so that liquid surface is flush with filter membrane;The sample to be measured content is placed above filter membrane;At specified temperature, rotation speed, sample is taken from the lower part of diffusion cell at different time points, and the concentration of calcitriol is determined.The method of the application can accurately and conveniently evaluate the in vitro release behavior of calcitriol soft capsule content prepared by different prescriptions or processes, has high correlation degree with in vivo effectiveness, and has good repeatability, to provide reliable in vitro evaluation tool for product quality control and prescription screening.

This invention relates to a staggered covalent organic framework thin film, its preparation method, and its application, belonging to the field of thin film technology. The invention first dissolves an amine monomer in acetic acid solution to obtain an aqueous solution; then dissolves an aldehyde monomer in mesitylene to obtain an organic solution; finally, the aqueous and organic solutions are added to the aqueous and organic phase chambers of a diffusion cell, respectively, for interfacial polymerization. After the reaction, the membrane material is removed, washed, and dried to obtain the staggered covalent organic framework thin film. This film forms a staggered stacked structure and constructs sub-nanometer transport channels with pore sizes of approximately 0.5 nm to 0.7 nm. Through a synergistic mechanism of Donnan repulsion and hydrogen bonding interactions, it maintains structural stability under extreme environments of high acidity, strong corrosion, and high radiation, achieving highly efficient selective permeation of protons and efficient retention of metal ions in high-level radioactive waste liquids.

Disclosed herein a carbon-dioxide selective gas membrane supporting a metal-doped laser-induced graphene conductive layer. The membrane may be used for electrocatalytic reduction of carbon dioxide using gas diffusion cells.

The present application provides a high skin permeation effect truffle vesicle-nicotinamide composition, which uses natural nanovesicles extracted from truffles as carriers, and encapsulates hydrophobic drug nicotinamide by ultrasonic method to form truffle vesicle-nicotinamide composition. The preparation method comprises the steps of extraction and purification of truffle vesicles, ultrasonic drug loading with nicotinamide, and ultrafiltration purification. The composition is characterized by transmission electron microscopy, and the particle size is uniform, about 30-200 nm, and the encapsulation efficiency can reach more than 75%. In vitro Franz diffusion cell experiment shows that the composition can significantly enhance the skin permeability of nicotinamide, and can promote the accumulation of drugs in the epidermis and dermis. The composition has the natural biological activity of truffle and the pharmacological efficacy of nicotinamide, and can be used for preparing transdermal preparations with the effects of whitening, anti-aging, repair, etc., and has a wide application prospect in the field of cosmetics and skin local administration.

The application belongs to the technical field of membrane separation, and particularly relates to a composite membrane and a preparation method and device thereof, which comprises the following steps: S1, a macroporous neutral charge base membrane is selected, a supporting substrate is used to support the base membrane, and the base membrane is assembled into a polytetrafluoroethylene diffusion cell to divide the diffusion cell into two independent chambers; S2, a ligand solution is prepared and injected, and a metal organic framework precursor solution is prepared according to a 1:1 molar ratio; metal organic framework materials with sub-nanometer channels are synthesized in-situ in membrane holes through diffusion effects of two specific ligands in the membrane holes, and the membrane holes of the base membrane are filled with the materials to prepare a high-performance composite membrane, the synthesis process of the membrane material avoids inevitable surface charges and defects of the metal organic framework materials in a traditional membrane preparation method, the mechanical strength of the composite membrane is improved by introducing a polymer base, and the sub-nanometer channels of the neutral charge metal organic framework materials are used for lithium-magnesium separation.