33 results about "Neutral Charge" patented technology

An OLED device comprises a cathode, a light emitting layer and an anode, in that order, and, has located between the cathode and the light emitting layer, a further layer containing a cyclometallated complex represented by Formula (4′) wherein: Z and the dashed arc represent two or three atoms and the bonds necessary to complete a 5- or 6-membered ring with M; each A represents H or a substituent and each B represents an independently selected substituent on the Z atoms, provided that two or more substituents may combine to form a fused ring or a fused ring system; j is 0-3 and k is 1 or 2; M represents a Group IA, IIA, IIIA and IIB element of the Periodic Table; m and n are independently selected integers selected to provide a neutral charge on the complex; and provided that the complex does not contain the 8-hydroxyquinolate ligand.

Such devices exhibit reduce drive voltage while maintaining good luminance.

A device and a method for printing biomolecules onto a substrate using an electrohydrodynamic (EHD) effect are provided. The device for printing biomolecules onto a substrate using an electrohydrodynamic (EHD) effect includes at least one capillary having an outlet through which a feeding solution of biomolecules selected from the group consisting of nucleic acids, proteins, and oligopeptides is discharged, the nucleic acids being selected from the group consisting of probe DNA, RNA, peptide nucleic acid (PNA), and LNA and the proteins being selected from the group consisting of antigen and antibody; a printer body supporting the at least one capillary; a substrate below the outlet having a target surface onto which the biomolecules are deposited; a first electric field forming electrode located on the printer body around the circumference of the outlet; a second electric field forming electrode spaced apart from the first electrode by a predetermined distance; and a voltage applying unit which is electrically connected to the first electrode and the second electrode to apply an alternating current (AC) voltage between the first electrode and the second electrode so that an electric field may be formed around the biomolecule solution suspended in the outlet, and due to the interaction of the electric field and a difference in dielectric constant between the biomolecule solution having a free surface and the surrounding atmosphere, the electric force acts inward on the biomolecule solution from the surroundings, thereby dropping a predetermined amount of the biomolecule solution onto the target surface of the substrate. By using an EHD effect, the advantages of the device and method are that the process is quick, the biomolecule spots are uniform and easily aligned, and especially it is possible to spot the biomolecules correctly and reproducibly even when the printer body is not fully aligned with the substrate. In addition, the device and method are applicable to proteins which are sensitive to heat and biomolecules which have neutral charges.

The invention discloses a method of improving directional imaging ability of carbon dots to cell nucleolus. The method includes: using citric acid and ethylene diamine as carbon sources to prepare carbon dots; adjusting the surfaces of the carbon dots from negative charge to close to neutral so as to improve directional imaging ability of the carbon dots to the cell nucleolus. Common organic saltis used as a carbon source and simply treated to prepare the carbon dots. Effect of the carbon dots on nucleolus imaging is improved by changing charge on the surfaces of the obtained carbon dots, andthe carbon dots with the surfaces in neutral charge have better directional imaging effect on the nucleolus.

The present invention describes rhodamine compounds particularly well-suited for pre-labeling a protein that is then subjected to two-dimensional electrophoresis. Isomeric purification and synthesis of a dye having net neutral charge or no charge precludes interference with isoelectric electrophoretic separation.

Differential surface-charge-dependent localization of nanoceria in normal cells and cancer cells plays a critical role in the toxicity profile of a nanoceria particle. Engineered surface-coated cerium oxide nanoparticles with different surface charges that are positive, negative and neutral provide therapeutic results for normal and cancer cell lines. Results show that nanoceria with a positive or neutral charge enters most of the cell lines studied, while nanoceria with a negative charge internalizes mostly in the cancer cell lines. Moreover, upon entry into the cells, nanoceria is localized to different cell compartments (e.g. cytoplasm and lysosomes) depending on the nanoparticle surface charge. The internalization and subcellular localization of nanoceria plays a key role in the nanoparticle cytotoxicity profile, exhibiting significant toxicity when they localize in the lysosomes of the cancer cell lines. In contrast, minimal toxicity is observed when they localize into the cytoplasm or do not enter the cells.

The present invention relates to relates to a nanoparticle that includes a shell formed from a first monomer having a first charge and a second monomer different than the first monomer. The first and second monomers are copolymerized, and the shell encapsulates a core region and is associated with a charged entity having a second charge of opposite sign to the first charge. The present invention further relates to a nanoparticle having a neutral charge. The present invention further relates to nanoparticle dispersions, methods of making the nanoparticle, methods of method of imaging, methods of delivering drugs, and methods of delivering a high concentration of contrast enhancing and/or imaging agents.

The invention discloses a supercritical/sub-critical water blocking method of HPLC (High Performance Liquid Chromatography) reversed phase bonded stationary phase, which comprises the steps of using carbon dioxide supercritical fluid and/or carbon dioxide sub-critical fluid as a carrier, bring a blocking reagent and a catalyst into a supercritical/sub-critical fluid reactor loaded with silica gel reversed phase bonded stationary phase, and carrying out blocking reaction under a closed condition. According to the method, residual active silanol groups can be thoroughly closed, and lyophobic reversed phase bonded stationary phase with complete neutral charge is produced; no residual active silanol groups exchanges side effects with alkali compound cations, so that alkali compound has a very symmetrical peak shape, and the retention time and mechanism fully follow the order from low to high of hydrophobicity of the compound. The method has the advantages that the reaction condition is mild, the reversed phase bonded stationary phase has no damage, the life of a chromatographic column is long, the repeatability of production batches is very good, the use amount of a toxic organic solvent, such as methylbenzene, is minimized, the pollution to the environment is reduced to the greatest extent, and the process continuity and semi-automatization can be realized.

A hydrophilic silicone, compositions comprising the same, and articles comprising the same are shown and described herein. The hydrophilic silicone is an ionically modified silicone compound wherein the compound has a net neutral charge. The hydrophilic silicone compounds may be provided as part of a composition, e.g., a composition suitable for forming a hydrogel, which may be employed to form afilm material and even an article (e.g., in a contact lens).

A solid oxide fuel cell includes a porous anode, a dense electrolyte in contact with the porous anode, and a porous cathode in contact with the dense electrolyte. The porous cathode is characterized by a single-phase structure of Brownmillerite or Srebrodolskite, the composition thereof having the formula

(Ca_2-xA_x)(Fe_2-yB_y)O_5±z

wherein: A is at least one element selected from the group: rare earth elements, Bi, and alkaline elements; B is at least one element selected from the group: Al, Ga, In, Mg, Si, and transition metal elements; 0≦x<2; 0≦y<2; and z is a variable, the value of which is such that the overall composition has a generally neutral charge state.

A composition for forming an electrically conductive antistatic layer comprises: electronically conductive polymer particles; a neutral-charge conductivity enhancer; and a hydrophilic polymeric binder.

In various embodiments, the present invention is a method and apparatus for label-free detection and optional quantification of double-stranded nucleic acid comprising binding a first layer comprising a charged species to a sensing surface having an associated first charge, wherein the first layer confers to the sensing surface a second charge or a neutral charge on a net basis, performing at least one cycle of DNA amplification to produce a double-stranded nucleic acid, and measuring a property of the interaction between the first layer and the double-stranded nucleic acid after the at least one cycle of DNA amplification. The present invention may be used in a cyclic manner, corresponding with the cyclic nature of DNA amplification processes.

The invention provides a cell penetrating peptide with neutral charge, wherein the net charge of the cell penetrating peptide under physiological conditions is 0. The invention also provides a specific amino acid sequence. The invention also provides application of the cell penetrating peptide with neutral charge as a delivery carrier in cells, medical application of the cell penetrating peptide with neutral charge as the delivery carrier of therapeutic drugs in cells, and application of the cell penetrating peptide with neutral charge as a contrast agent in the medical imaging technology of the delivery carrier in cells. Furthermore, homologues of the cell penetrating peptide with neutral charge also have cell penetrating performance and can medically serve as the delivery carrier in cells as well as serve as the delivery carrier of the therapeutic drugs in cells.

An indolium compound is represented by formula (I):

Ring A: a benzene or naphthalene ring. Ring B: 5- or 6-membered heterocyclic or aromatic ring. Z: alkyl group having 1-8 carbon atoms, may be substituted with a halogen atom or interrupted by —O—, —CO—, —OCO—, or —COO—, a sulfonyl group having a hydrocarbyl group having -8 carbon atoms, a sulfinyl group having a hydrocarbyl group having 1-8 carbon atoms, an alkylamino group having an alkyl group having 1-8 carbon atoms, a dialkylamino group having alkyl groups having 1-8 carbon atoms, a cyano group, a nitro group, a hydroxyl group, or a halogen group. R¹: group represented by formula (II) or (II′). R²: organic group having 1-30 carbon atoms or group represented by formula (II), (II′), or (III). Y: group represented by formula (III). n: integer 0-4; An^m−: m-valent anion, m is 1 or 2. p: coefficient for neutral charge: