Hydrogel as well as preparation method and purpose of hydrogel

Abstract

The invention relates to hydrogel as well as a preparation method and a purpose of the hydrogel. The hydrogel is prepared through electron beam or Gamma-ray radiation on natural polymers or derivates of the natural polymers after the medicine active ingredient loading in oxygen-free environment. The hydrogel has good biocompatibility and use safety, the biological effects of the natural polymers or the derivates of the natural polymers on the wound healing and the skin repair protection can be permanently and fully exerted in local parts in the hydrogel mode, good medicine slow release functions of the hydrogel are also fully utilized, the required medicine active ingredients are specifically added, good efficiencies and wide purposes are given to the hydrogel, and the hydrogel can be used in the fields of skin, mucosa and cornea wound dressings, filling materials, tissue engineering materials, cell culture media and the like, and can also be used in the field of daily use articles such as skin care products and cosmetics.

Description

technical field [0001] The invention relates to the field of medical natural polymer materials, in particular to a hydrogel and its preparation method and application. Background technique [0002] In recent years, the theory of wet environment of wound has been paid more and more attention. Studies have shown that maintaining an appropriate local moist environment on the wound is conducive to the removal of necrotic tissue, the formation of a closed environment to prevent the invasion of pathogenic bacteria, the proliferation, differentiation and migration of fibroblasts and epithelial cells, and the avoidance of dry scabs. Wounds cause mechanical damage, which is very important for wound healing. However, the current clinical local treatment methods still use gauze to cover the wound surface, which is easy to cause water loss and cannot effectively block the invasion of pathogenic microorganisms. The repeated replacement process can easily damage the new tissue and affect...

AI Technical Summary

Problems solved by technology

At present, natural polymers are gradually being used in skin wound repair and maintenance, but most of them are solutions or sprays and other preparations, which cannot stay on the skin surface for a long time to play a role

Some pharmaceutical active ingredients that have a good promoting effect on skin wound repair, such as basic fibroblast growth factor, epidermal growth factor, nano-silver, povidone-iodine, etc., also cannot play a lasting role due to the lack of a good route of administration

How to make full use of the biological effects of natural polymers and related pharmaceutical active ingredients to prepare safe and efficient dressings is still no satisfactory solution