Hydrogel as well as preparation method and purpose of hydrogel

A technology of hydrogel and aqueous solution, applied in the field of hydrogel and its preparation, can solve the problems of lack of administration route, unable to play a long-lasting effect, etc., and achieve good biocompatibility, safety in use, and good drug sustained-release function. , to promote the effect of wound repair

Inactive Publication Date: 2013-05-01
刘昌桂
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, natural polymers are gradually being used in skin wound repair and maintenance, but most of them are solutions or sprays and other preparations, which cannot stay on the skin surface for a long time to play a role
Some pharmaceutical active ingredients that have a good promoting effect on skin wound repair, such as basic fibroblast

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Weigh 10 g of carboxymethyl chitosan and 500 μg of recombinant human epidermal growth factor, add 100 g of water, and fully dissolve; slowly pour the solution into a mold to a thickness of 1 mm, seal it in a bag, fill it with nitrogen, and irradiate it with an electron beam. The irradiation dose was 20KGy to obtain hydrogel samples. The hydrogel had a gel fraction of 32% and a swelling degree of 49.

Embodiment 2

[0030] Weigh 30g of carboxymethyl chitosan, 500μg of recombinant human epidermal growth factor, 500μg of recombinant human basic fibroblast growth factor, add 100g of water, and fully dissolve; slowly pour the solution into the mold to a thickness of 4mm, and seal the bag After encapsulating and filling with nitrogen gas, it is irradiated with an electron beam, and the irradiation dose is 30KGy to obtain a hydrogel sample. The hydrogel had a gel fraction of 44% and a swelling degree of 63.

Embodiment 3

[0032] Weigh 20 g of carboxymethyl chitosan, 30 g of sodium alginate, and 500 μg of recombinant human epidermal growth factor, add 100 g of water, and fully dissolve; slowly pour the solution into the mold to a thickness of 4 mm, seal it in a sealed bag, fill it with nitrogen, and use it. Electron beam irradiation with an irradiation dose of 30KGy to obtain a hydrogel sample with a gel fraction of 45% and a swelling degree of 62.

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PUM

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Abstract

The invention relates to hydrogel as well as a preparation method and a purpose of the hydrogel. The hydrogel is prepared through electron beam or Gamma-ray radiation on natural polymers or derivates of the natural polymers after the medicine active ingredient loading in oxygen-free environment. The hydrogel has good biocompatibility and use safety, the biological effects of the natural polymers or the derivates of the natural polymers on the wound healing and the skin repair protection can be permanently and fully exerted in local parts in the hydrogel mode, good medicine slow release functions of the hydrogel are also fully utilized, the required medicine active ingredients are specifically added, good efficiencies and wide purposes are given to the hydrogel, and the hydrogel can be used in the fields of skin, mucosa and cornea wound dressings, filling materials, tissue engineering materials, cell culture media and the like, and can also be used in the field of daily use articles such as skin care products and cosmetics.

Description

technical field [0001] The invention relates to the field of medical natural polymer materials, in particular to a hydrogel and its preparation method and application. Background technique [0002] In recent years, the theory of wet environment of wound has been paid more and more attention. Studies have shown that maintaining an appropriate local moist environment on the wound is conducive to the removal of necrotic tissue, the formation of a closed environment to prevent the invasion of pathogenic bacteria, the proliferation, differentiation and migration of fibroblasts and epithelial cells, and the avoidance of dry scabs. Wounds cause mechanical damage, which is very important for wound healing. However, the current clinical local treatment methods still use gauze to cover the wound surface, which is easy to cause water loss and cannot effectively block the invasion of pathogenic microorganisms. The repeated replacement process can easily damage the new tissue and affect...

Claims

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Application Information

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IPC IPC(8): A61L15/22A61L15/44A61L15/28A61L15/32A61L15/42A61L27/14A61L27/54A61L27/20A61L27/24A61L27/26A61L27/52A61K8/73A61K8/65A61K8/81A61K8/67A61K8/04A61Q19/00C08J3/28C12N5/00
Inventor 刘昌桂
Owner 刘昌桂
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