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Pharmaceutical composition capable of promoting excretion of lead, and preparation method and application thereof

A composition and drug technology, applied in the direction of drug combination, medical formula, medical preparations containing active ingredients, etc., can solve the problems of ineffective effect, slow lead discharge speed, kidney damage, etc., achieve no toxic side effects, promote discharge The effect of lead, good promotion and application value

Inactive Publication Date: 2014-11-19
SICHUAN SAINTHOOD BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, DMSA must be used through intravenous injection. Although the lead-expelling effect is good, it can quickly reduce the lead load in the body, but it will have a strong complexation effect on other trace elements in the human body, and will release iron, zinc, etc. to the human body at the same time as lead-expelling. Beneficial trace elements are excreted from the body, and long-term use can also cause side effects such as kidney damage; Chinese herbal medicine preparations have little side effects on the human body, but the rate of lead discharge is slow and the effect is not obvious

Method used

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  • Pharmaceutical composition capable of promoting excretion of lead, and preparation method and application thereof
  • Pharmaceutical composition capable of promoting excretion of lead, and preparation method and application thereof

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Comparison scheme
Effect test

Embodiment 1

[0034] Embodiment 1 The preparation method of the pharmaceutical composition of the present invention

[0035] Prescription: 20 parts of plantain, 12 parts of desmodium, 13 parts of astragalus, 0.05 parts of iron sodium EDTA

[0036] Preparation method:

[0037] 1. Take plantain, desmodium and astragalus respectively, add water and boil three times. Add water 6 times its weight for the first time, soak for 1 hour, then decoct for 2 hours; add water 5 times its weight for the second time, decoct for 1 hour; add water 4 times its weight for the third time, decoct 1 hour, filter, combine the filtrates, heat and concentrate to a relative density of 1.09-1.12 at 60-65°C;

[0038] 2. Spray-dry the above-mentioned concentrated solution through a high-speed centrifugal spray dryer to prepare 80-120 mesh dry extract powder;

[0039] 3. According to the extraction rate of plantain, desmodium and astragalus single herbs, weigh each dry extract powder according to the formula ratio and...

Embodiment 2

[0040] Embodiment 2 The preparation method of the pharmaceutical composition of the present invention

[0041] Prescription: 24 parts of plantain, 15 parts of desmodium, 15 parts of astragalus, 0.5 part of iron sodium EDTA

[0042] Preparation method:

[0043] 1. Take plantain, desmodium and astragalus respectively, add water and boil three times. Add water 6 times its weight for the first time, soak for 1 hour, then decoct for 2 hours; add water 5 times its weight for the second time, decoct for 1 hour; add water 4 times its weight for the third time, decoct 1 hour, filter, combine the filtrates, heat and concentrate to a relative density of 1.09-1.12 at 60-65°C;

[0044]2. Spray-dry the above-mentioned concentrated solution through a high-speed centrifugal spray dryer to prepare 80-120 mesh dry extract powder;

[0045] 3. According to the extraction rate of plantain, desmodium and astragalus single herbs, weigh each dry extract powder according to the formula ratio and mi...

Embodiment 3

[0046] Embodiment 3 The preparation method of the pharmaceutical composition of the present invention

[0047] Prescription: 28 parts of plantain, 18 parts of desmodium, 16 parts of astragalus, 0.8 parts of iron sodium EDTA

[0048] Preparation method:

[0049] 1. Take plantain, desmodium and astragalus respectively, add water and boil three times. Add water 6 times its weight for the first time, soak for 1 hour, then decoct for 2 hours; add water 5 times its weight for the second time, decoct for 1 hour; add water 4 times its weight for the third time, decoct 1 hour, filter, combine the filtrates, heat and concentrate to a relative density of 1.09-1.12 at 60-65°C;

[0050] 2. Spray-dry the above-mentioned concentrated solution through a high-speed centrifugal spray dryer to prepare 80-120 mesh dry extract powder;

[0051] 3. According to the extraction rate of plantain, desmodium and astragalus single herbs, weigh each dry extract powder according to the formula ratio and ...

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Abstract

The invention provides a pharmaceutical composition capable of promoting excretion of lead. Raw materials of the pharmaceutical composition comprise, by weight, 20-35 parts of plantain herb, 12-24 parts of herba lysimachiae, 13-16 parts of radix astragali and 0.05-1 part of EDTA ferric sodium salt. The pharmaceutical composition combines three traditional Chinese medicines of plantain herb, herba lysimachiae and radix astragali with EDTA ferric sodium salt, and plays a synergistic effect. The pharmaceutical composition provided by the invention can promote the excretion of lead, alleviate or prevent damages of lead poisoning to a human body, has no toxic or side effect, is suitable for being taken by people with high blood lead for a long time, and has very good popularization and application values.

Description

technical field [0001] The invention relates to a pharmaceutical composition for promoting lead discharge, a preparation method and application thereof. Background technique [0002] Lead is a heavy metal element with neurotoxins. It is a cumulative toxin and has no physiological effects in the human body. The ideal blood lead concentration is zero. Lead has a strong affinity to body tissues, and the excretion speed is very slow, and by affecting the essential elements of the human body, it disturbs the balance of the physiological combination and proportional relationship of the essential elements in the human body, thereby disturbing the enzyme system in the body and the synthesis of biological macromolecules. Physiological activity, the enzyme system in the body loses its normal physiological activity and other regulation functions that regulate the balance of body functions are disturbed, which in turn affects multiple systems of the human body, among which the nervous s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/68A61P39/02A61K31/295
Inventor 郭小雪严晓玲钟莉沙张弘钟雨禅黄泽祥李改丽
Owner SICHUAN SAINTHOOD BIOTECH
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