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75results about How to "Reduce savings" patented technology

Tumor microenvironment response fusion protein-metal ion compound prodrug system as well as preparation method and application thereof

The invention provides a novel platform for tumor immunotherapy. The platform is formed by self-assembly of full-heavy-chain human ferritin which can be jointly fused and expressed by a polypeptide prodrug mask which can be activated by protease and a mitochondrial disrupting peptide, and can specifically target a tumor microenvironment and induce ICD death of tumors. Meanwhile, an ion channel is formed in a protein shell of the platform, so that immunocompetence metal ions can be loaded in a cavity of the platform, and time-space synchronous anti-tumor immune activation can be carried out in cooperation with ICD. As the mitochondrial disrupting peptide and the metal ions can be optimized according to tumor types, the platform can be used for treating various tumors.
Owner:CHINA PHARM UNIV

Water cooling system and control method

The invention relates to the technical field of refrigeration control, in particular to a water cooling system, a control method and a first-stage water cooling assembly, the water cooling system comprises a first circulation loop piece, a first control piece and a first adjusting piece, the first control piece is arranged on the first circulation loop piece, and the first adjusting piece is arranged on the first circulation loop piece; the second-stage water cooling assembly comprises a second circulation loop piece, a second control piece and a second adjusting piece, the second circulation loop piece is arranged on the first control piece and the first adjusting piece, the second control piece is arranged on the second circulation loop piece, the second adjusting piece is arranged on the second circulation loop piece, and the second control piece is arranged on the second circulation loop piece. Through interaction between the first-stage water cooling assembly and the second-stage water cooling assembly and combination of fuzzy control through PID, when semiconductor equipment and a particle accelerator operate, the water inlet temperature of a load can be accurately controlled.
Owner:CHANGZHOU BORI ELECTRIC POWER AUTOMATION EQUIP

HER2 (human epidermal growth factor receptor 2) targeting antibody coupling gold (III) porphyrin medicine as well as synthesis and tumor treatment application of HER2 targeting antibody coupling gold (III) porphyrin medicine

The invention relates to an HER2 (human epidermal growth factor receptor 2) targeting antibody coupling gold (III) porphyrin medicine as well as a synthesis method and tumor treatment application thereof. The antibody coupling gold (III) porphyrin drug targeting HER2 is formed by connecting an anti-HER-2 trastuzumab and an A3B type gold (III) porphyrin complex through a linker, and the linker comprises a maleimide joint connected with an antibody and a self-elimination joint connected with the A3B type gold (III) porphyrin complex. The A3B type gold (III) porphyrin complex with anti-tumor activity is combined with trastuzumab with a specific recognition function as a carrier, the antibody is utilized to accurately strike tumor cells, a medicine is delivered to a tumor environment, the tumor targeting property of the gold (III) porphyrin complex is improved, and accurate treatment is realized. Distribution of drugs in the body can be improved, accumulation of the drugs in non-tumor sites can be reduced, the dosage of metal complexes is reduced, and toxic and side effects are reduced; the efficient delivery of gold drugs to tumor tissues can also be realized, and the cancer treatment effect is improved.
Owner:GAOBO PHARM CO LTD

Enhanced penetration type double-response nanoparticles for co-delivery of chemotherapeutic drugs and gene drugs as well as preparation method and application of enhanced penetration type double-response nanoparticles

The invention belongs to the technical field of medicines, and particularly relates to enhanced penetration type double-response nanoparticles for co-delivery of chemotherapeutic drugs and gene drugs as well as a preparation method and application thereof. According to the invention, albumin is used as a carrier of gemcitabine, an ROS responsive charge reversible cationic polymer is used as a delivery carrier of siRNA, and gemcitabine drug-loaded albumin and siRNA drug-loaded B-PDEA nanoparticles are coupled through MMP-2 responsive polypeptide to form the drug-loaded nanoparticles. After reaching a tumor area through the active targeting effect of albumin, the nanoparticles can be cut by MMP-2 in a microenvironment and release drug-loaded albumin, so that the size of a delivery system is reduced, and further tumor deep penetration and enhanced gemcitabine uptake are realized; meanwhile, after intracellular high-level ROS is recognized, the loaded siRNA can be selectively released and inhibit CD39 expression, tumor metabolism is adjusted, an immune microenvironment is remodeled and an anti-tumor immune response is activated to further realize chemotherapy sensitization while precise chemotherapy is performed, and the therapeutic efficacy on pancreatic cancer is expected to be enhanced.
Owner:FUDAN UNIVERSITY

Pharmaceutical composition containing thyroxine receptor stimulant and folic acid substances

The invention provides a pharmaceutical composition. The pharmaceutical composition is composed of a thyroxine receptor beta agonist, folic acid substances and pharmaceutically acceptable auxiliary materials. The invention also relates to application of the composition in preparation of drugs for treating chronic fatty liver diseases. The pharmaceutical composition has the advantages that the pharmaceutical composition can be used for treating the fatty liver accompanied by hypothyroidism, and adverse reactions generated by independently taking a thyroid receptor beta agonist can be reduced.
Owner:SHENZHEN AUSA PHARM CO LTD +1

Heat dissipation structure of cabinet

The utility model discloses a heat dissipation structure of a cabinet, comprising a cabinet, the outer side wall of the cabinet is provided with a groove communicated with the inside of the cabinet, the groove is internally provided with a heat dissipation filter screen, the cabinet is provided with a cleaning assembly used for cleaning the heat dissipation filter screen, and the cleaning assembly comprises a driving assembly, a cleaning assembly and an air supply assembly. The air supply assembly is connected with the driving assembly and the cleaning assembly, and the driving assembly is used for driving the air supply assembly to move in the direction close to or away from the heat dissipation filter screen so that the air supply assembly can drive the cleaning assembly to move in the direction close to or away from the heat dissipation filter screen. According to the utility model, rapid heat dissipation of the cabinet can be realized, dust on the heat dissipation net can be cleaned, and the heat dissipation efficiency is improved.
Owner:CHINA MOBILE GROUP DESIGN INST +1

An oxygen mask capable of absorbing and detecting end-tidal carbon dioxide

ActiveCN118576854Bavoid rebreathingreduce savingsRespiratory masksSensorsEnvironmental engineeringOxygen breathing
This invention discloses an oxygen mask capable of adsorbing and detecting end-tidal carbon dioxide, relating to the field of oxygen mask technology. It includes a mask body with a detection box and an adsorption box on its inner surface. The detection box contains a detection substance used to detect carbon dioxide concentration. The adsorption box contains an adsorbent substance capable of adsorbing carbon dioxide exhaled by a patient. The mask body has multiple air outlets and several oxygen channels. The air inlets of the oxygen channels are located on the outer surface of the mask body, and the air outlets are located on the inner surface. This invention effectively detects the concentration of carbon dioxide exhaled by a patient through the detection box, while the adsorption box effectively prevents the patient from re-inhaling carbon dioxide. The device has a simple overall structure, is easy to use, and has low manufacturing costs.
Owner:BEIJING CANCER HOSPITAL PEKING UNIV CANCER HOSPITAL

Anti-blocking engine oil filter

The utility model discloses an anti-blocking engine oil filter which comprises an outer shell, the top of the outer shell is detachably connected with a top cover through threads, the top cover is provided with a plurality of oil inlet pipes, the inner sides of the oil inlet pipes are provided with spiral flow guide channels, the middle position of the top cover is provided with an oil outlet, and the lower side of the top cover is fixedly provided with a connecting ring. The lower side of the connecting ring is connected with a multi-filtering mechanism, the multi-filtering mechanism comprises an inner filter element framework, a middle filter element framework, an outer filter element framework, an inner-layer filter element, a middle-layer filter element and an outer-layer filter element, the inner filter element framework, the middle filter element framework and the outer filter element framework are all fixed with the connecting ring, the inner-layer filter element is fixedly mounted on the outer side of the inner filter element framework, and the outer-layer filter element is fixedly mounted on the outer side of the middle-layer filter element framework. A middle-layer filter element is fixedly mounted on the outer side of the middle filter element framework, and an outer-layer filter element is fixedly mounted on the outer side of the outer filter element framework. According to the utility model, impurities directly accumulated on the filter elements are reduced through the centrifugal effect, and then the quantity of impurities on each layer of filter element is reduced through multi-layer filtration, so that the risk of overall blockage is reduced.
Owner:ZHEJIANG BILUNTE AUTO PARTS CO LTD

A lactobacillus and its application in preventing and controlling bacterial infection in livestock and poultry

The present application relates to the field of microorganisms, and specifically discloses a lactic acid bacterium and its application in preventing and controlling bacterial infections in livestock and poultry. The lactic acid bacterium is produced by fermentation of Lactococcus lactis. The strain is named Lactococcus lactis 5019 and was deposited in the General Microbiological Center of the China Microbiological Culture Collection Administration on January 13, 2021. The deposit address is: Beijing, China, and the deposit number is CGMCC NO.21607. The lactic acid bacterium produced by Lactococcus lactis in the present application can be used to prevent and control bacterial infections in livestock and poultry, and it has the advantages of high temperature resistance and strong antibacterial activity.
Owner:QINGDAO PHAGEPHARM BIO TECH CO LTD

Application of lactobacillus in the preparation of medicine for preventing and / or treating liver and / or kidney and / or bone damage caused by excessive intake of fluoride

The present invention provides an application of lactobacillus in the preparation of a medicine for preventing and / or treating liver and / or kidney and / or bone damage caused by excessive intake of fluoride, and relates to the technical field of lactobacillus application. The present invention achieves the purpose of preventing and / or treating damage to the liver and / or kidney and / or bone by reducing the accumulation of fluoride in the liver and / or kidney and / or bone, and the lactobacillus is Lactobacillus johnsonii BS15. Lactobacillus johnsonii BS15 is used to reduce the accumulation of fluoride in the body, especially in the liver, kidney and bone during high fluoride exposure, improve the damage to organs caused by high fluoride exposure, promote the excretion of fluoride from the body, promote the excretion of fluoride from the kidney, promote the excretion of fluoride in feces and urine, and improve the damage to the liver, kidney, lung and nerve center of mice. It is safe and effective to use, has no toxic side effects, and has a wider application.
Owner:BEIJING GUOYING ZHILIAN BIOENGINEERING TECHNOLOGY CO LTD

Efficient filter bag environment-friendly dust collecting cloth bag

The utility model discloses a high-efficiency environment-friendly dust collecting cloth bag, and relates to the technical field of dust collecting cloth bags. The cloth bag comprises a cloth bag body, a plurality of traction ropes are fixedly installed on the inner side wall of the cloth bag body, a supporting mechanism is fixedly installed at one ends of the traction ropes, a connecting rod is rotatably installed on the supporting mechanism, a power rotating mechanism is fixedly arranged on the side wall of the connecting rod in a sleeved mode, and the power rotating mechanism is fixedly connected with the traction ropes. A connecting rope is fixedly mounted at the other end of the connecting rod, and a plurality of dust removal mechanisms are arranged on the connecting rope. According to the utility model, objects such as the falling rope and the impact block on the connecting rope form impact vibration on the interior of the bag body under the action of centrifugal force, so that the accumulation of dust on the inner wall of the bag body is reduced, the good dust removal efficiency of the dust removal bag is effectively maintained, and the cleaning time of the dust removal bag is prolonged; the dust remover using the dust removal cloth bag can obtain better working efficiency, so that the operation cost of the dust remover is reduced.
Owner:JIANGSU DONGHUI ENVIRONMENTAL PROTECTION TECH CO LTD

Mitochondria-enriched extracellular vesicles, and preparation method and application thereof

This invention relates to mitochondrial-enriched extracellular vesicles, their preparation methods, and applications, which can effectively solve the drug problem in spontaneous intracerebral hemorrhage. The technical solution involves using platelets as raw material, and obtaining platelet-derived extracellular vesicles carrying active mitochondria through activation induction, differential centrifugation and fractionation, membrane filtration and elution enrichment. This achieves efficient and stable loading of functional mitochondria, and the resulting PEV Mito has a complete structure and uniform particle size, which can effectively maintain mitochondrial membrane potential and biological activity. It can achieve efficient delivery and intracellular internalization to damaged neurons and restore mitochondrial function. The PEV Mito prepared by this invention has high delivery efficiency and excellent biocompatibility, and can be used to prepare drugs for the treatment of intracerebral hemorrhage and secondary neurological injury, with good prospects for clinical translation.
Owner:ZHENGZHOU UNIV

Tea bag for treating gout

The invention relates to the technical field of traditional Chinese medicines, and particularly discloses a teabag for treating gout, which is prepared from the following raw materials in parts by weight: 30-40 parts of dandelion, 8-16 parts of turmeric, 20-26 parts of fructus liquidambaris, 8-16 parts of selfheal, 5-10 parts of radix cyathulae, 20-26 parts of lophatherum gracile, 5-10 parts of rehmannia and 10-18 parts of parasitic loranthus. The teabag has the beneficial effects that the teabag is prepared from pure traditional Chinese medicines, is simple and convenient to take, has no toxic or side effect, can resist inflammation and diminish swelling, clear heat and purge fire, dredge collaterals and stop pain, induce diuresis and discharge uric acid, regulate body functions and promote uric acid reduction after being brewed and drunk for a long time, and has a good curative effect on joint redness and swelling, burning and scalding and pain caused by gout.
Owner:姚康孟

Civil engineering hydraulic rod supporting frame

The utility model discloses a civil engineering hydraulic rod supporting frame which comprises a supporting assembly and sealing assemblies, the top of the supporting assembly is fixedly connected with a circular supporting assembly, the circular supporting assembly is connected between the sealing assemblies in a threaded mode, and each sealing assembly comprises a large bolt and a limiting plate. And one end of the inner side of the large bolt is clamped to the outer side surface of a limiting plate, the inner side of the limiting plate is connected with a telescopic rod, and one end of the inner side of the telescopic rod is connected with a clamping plate. The utility model relates to the technical field of civil engineering. According to the civil engineering hydraulic rod supporting frame, a large bolt is rotated by rotating a round handle, and the large bolt is screwed to achieve the purpose of pushing a limiting plate, so that a telescopic rod on the inner side of the limiting plate is pushed, an electric telescopic rod is opened to push a sliding block, the lower half part of a sealing assembly moves, and the clamping area of the civil engineering hydraulic rod supporting frame is increased; therefore, the effects of large contact area and stability of the civil engineering hydraulic rod supporting frame and the hydraulic support are achieved.
Owner:JIANGSU GAOLAN TECHNOLOGY ENGINEERING CO LTD

Comfortable antistatic oxford fabric

The utility model discloses a comfortable anti-static oxford fabric, relates to the technical field of oxford fabrics, and aims to solve the problem that part of the oxford fabrics are poor in anti-static performance. According to the key points of the technical scheme, the comfortable anti-static mattress comprises a comfortable inner layer and an anti-static outer layer which are fixedly connected with each other, the section of the comfortable inner layer is wavy, a plurality of supporting pieces are fixedly connected to the side, away from the anti-static outer layer, of the comfortable inner layer, and the supporting pieces are close to the wave trough position of the comfortable inner layer and are symmetrical with the wave trough position as the central axis; the side, close to the comfortable inner layer, of the antistatic outer layer is fixedly connected with a plurality of antistatic balls, the antistatic performance of the fabric is enhanced through the antistatic balls, and the wavy comfortable inner layer can effectively reduce friction with the body surface of a user, so that generation of static electricity is reduced; the supporting piece not only can support the wave-shaped structure, but also can further reduce the contact area with the skin. According to the utility model, the copper ion fibers have better conductivity, so that the overall antistatic capability of the oxford fabric is ensured.
Owner:WUJIANG HAISHUN CHEM FIBER CO LTD

High-performance synergistic circulating filtration system

ActiveCN222550310Ureduce savingsReduce the frequency of disassembly and cleaningStationary filtering element filtersFiltrationProcess engineering
The utility model discloses a high-performance synergistic circulating filtration system which comprises a raw material pump, a residual liquid tank, a filter, a liquid inlet pipeline, a liquid outlet pipeline, a first circulating pipeline and a second circulating pipeline, the residual liquid tank is connected with an inlet of the raw material pump through the liquid inlet pipeline, an outlet of the raw material pump is connected with the liquid outlet pipeline, and the filter is connected with the first circulating pipeline through the liquid outlet pipeline. The liquid outlet pipeline is connected with the filter through a first circulating pipeline, and the filter is connected with the residual liquid tank through a second circulating pipeline. According to the utility model, when needed, the liquid inlet pipeline, the residual liquid tank and the corresponding circulating pipelines can be cleaned by closing the liquid outlet pipeline, opening the first circulating pipeline and the second circulating pipeline and introducing cleaning liquid, and solid residues brought in by the cleaning liquid in the cleaning process can be filtered through the filter, so that the cleaning efficiency is improved. Therefore, accumulation of solid residues in structures such as a raw material pump or a residual liquid tank is effectively reduced, the structures are prevented from being blocked, and the working efficiency of production treatment is improved.
Owner:DONGGUAN RUIZHONG NEW MATERIAL TECHNOLOGY CO LTD

A system for recycling tail gas of pressure swing adsorption and a propane dehydrogenation device

ActiveCN224807185UChange processing pathImprove overall recovery
The utility model relates to chemical industry process tail gas recovery technical field, concretely relates to a kind of pressure swing adsorption tail gas recycling system and propane dehydrogenation device, including the clean gas compressor, pressure swing adsorption unit, tail gas compressor and tail gas utilization unit sequentially communicated by main pipeline, still include circulation pipeline, its inlet end is connected in the outlet side main pipeline of the tail gas compressor, its outlet end is connected in the inlet side main pipeline of the clean gas compressor;The circulation pipeline is used to send the tail gas discharged from the pressure swing adsorption unit to the inlet of the clean gas compressor, and is combined with raw material gas leading to the clean gas compressor;The utility model can effectively improve hydrogen recovery rate, reduce tail gas emission and reduce external resource consumption.
Owner:JIANGSU SAILBOAT PETROCHEMICAL CO LTD

Intelligent power distribution cabinet used for electrical automation engineering and convenient to maintain

The utility model relates to the technical field of intelligent power distribution cabinets, and discloses an intelligent power distribution cabinet used for electrical automation engineering and convenient to maintain, which comprises a cabinet body, a power distribution device is arranged in the cabinet body, a second cabinet door is arranged on the left side of the cabinet body, and a lock body is arranged in the middle of the second cabinet door. The inner side of the second cabinet door is connected with a sealing strip, and the front side of the cabinet body is provided with a first cabinet door. According to the intelligent power distribution cabinet convenient to maintain and used for the electrical automation engineering, the door bodies are installed on the two adjacent sides of the intelligent power distribution cabinet, the operation range of workers can be enlarged, the working efficiency of the intelligent power distribution cabinet is improved, meanwhile, through cooperation of the first cabinet door and the second cabinet door, the leakproofness of the intelligent power distribution cabinet can be improved, and the service life of the intelligent power distribution cabinet is prolonged. And external dust and the like are prevented from adhering to the power distribution cabinet to influence the normal work of the power distribution cabinet.
Owner:JILIN YUECHENG TECHNOLOGY CO LTD

Water-saving sprinkling irrigation device for agriculture and forestry

InactiveCN121753693Areduce water outputMore water outputWatering devicesCultivating equipmentsSoil scienceAgricultural engineering
The invention provides a water-saving sprinkling irrigation device for agriculture and forestry. The water-saving sprinkling irrigation device comprises a movable seat body, a first irrigation unit, a second irrigation unit and a recovery unit. A water supply tank is arranged at the top end of the movable seat body; the first irrigation unit is provided with a plurality of water spraying parts facing the ground and is used for irrigating seedlings and low crops; the second irrigation unit is provided with two spraying parts which are symmetrically arranged in the width direction of the movable seat body, and the spraying parts are used for spraying water or pesticide to the shrubs; and the recovery unit is arranged on the movable seat body, is provided with two collecting parts corresponding to the two spraying parts respectively, and is used for recovering the liquid medicine overflowing from the shrubs or the spraying parts. According to the water-saving sprinkling irrigation device for agriculture and forestry, the first sprinkling irrigation unit and the second sprinkling irrigation unit which can be independently controlled are arranged, the device can be matched with various different types of plant shuttle planting scenes, part of water / pesticide liquid can be recycled, the water-saving effect is remarkable, and practicability is high.
Owner:CANGZHOU YANZHAO ENVIRONMENTAL MONITORING TECH SERVICE CO LTD

Skin repairing composition and preparation method thereof

The invention belongs to the technical field of skin repair, and particularly relates to a skin repair composition and a preparation method thereof.The skin repair composition is characterized by being prepared from carbomer, stearic acid, VitE, hydrolyzed pearl, bisabolol, olive oil emulsifying wax, glycerin, centella asiatica extract, vaseline, ethylparaben, methylparaben and water according to the mass ratio of (0.1-0.5): (1-10): (1-5): (1-5): (0.1-0.5): (1-5): (1-10): (0.1-1): (1-10): (0.1-1): (0.1-1): 1. The composition has the effects of repairing skin barriers and reducing redness, the skin irritation degree caused by external irritation is relieved, and the good soothing and repairing effects are achieved.
Owner:NANNING KANGRUICHENG TRADING CO LTD

Therapeutic composition for treating heparan sulfate accumulation diseases

The compositions disclosed herein are contemplated for use in the treatment and prevention of diseases caused by heparan sulfate accumulation, including mucopolysaccharide storage disorders, Alzheimer's disease, and cancer. These compositions include iminosugars belonging to the L-stereoseries and derivatives thereof as active ingredients. The L-iminosugar of the present invention can reduce the level of heparan sulfate in patient cells affected by mucopolysaccharide storage diseases and cancers, and reduce the accumulation of amyloid plaques in a neurodegenerative disease model. Thus, the use of these compounds prevents the occurrence of symptoms associated with these diseases, thereby improving the quality of life and longevity of patients suffering from diseases characterized by heparan sulfate accumulation.
Owner:SWALE THERAPEUTICS LLC

Plate type collecting pipe and heat exchanger

The utility model discloses a plate type collecting pipe and a heat exchanger. The plate type collecting pipe comprises a plurality of plates which are arranged in a stacked mode, the plates comprise end plates, flow plates, flow equalizing plates and flat pipe inserting plates which are sequentially arranged in a stacked mode and jointly define one or more fluid channels, and each fluid channel comprises a flow hole channel and a flat pipe inserting plate, the plurality of flat tube insertion hole channels are formed in the flat tube insertion plate so as to be suitable for insertion of flat tubes; and the flow equalizing hole channel is arranged on the flow equalizing plate and is communicated with the flow path hole channel and the plurality of flat tube insertion hole channels. According to the plate-type collecting pipe, a fluid channel with a small space can be built in the plate-type collecting pipe through the plate-type design, accumulation of refrigerants in the collecting pipe is reduced, the filling amount of the refrigerants is reduced, cost is reduced, and the plate-type collecting pipe is more environmentally friendly. And meanwhile, by introducing the flow equalizing plates and the flow equalizing hole channels, the uniformity of two-phase flow of the refrigerant is improved, and the heat exchanger applying the plate type collecting pipe has high heat exchange efficiency.
Owner:GRANGES ALUMINUM SHANGHAI CO LTD

Atmospheric pollution control equipment

The invention discloses atmospheric pollution control equipment which comprises a box body used for containing dust, an outer supporting plate and a collecting tank are fixed to the box body, a filtering unit is installed on one side of the outer supporting plate, and the lower end of the filtering unit communicates with the collecting tank; the filtering unit comprises an outer ring frame and an inner circular frame, the outer side of the outer ring frame is provided with a first conveying pipe and a second conveying pipe which are used for air inlet and outlet, the inner circular frame is arranged in the outer ring frame in a sleeved mode, a rotatable filtering component is arranged between the outer ring frame and the inner circular frame in a sleeved mode, and the inner circular frame can exhaust air downwards and is used for discharging dust in the filtering component into the box body. In the air filtering process, dust is blocked by the fluff layer, the filtering effect is completed, the fluff layer rotates to be vertically downward, the dust in the fluff layer is blown out from inside to outside under the action of air of the air pump, gaps of the fluff layer are variable, and dust accumulated in the fluff layer can be reduced as much as possible.
Owner:WENLING QIANYUAN ENVIRONMENTAL PROTECTION TECH CO LTD

A tumor cell and mitochondria dual-level targeting tripterygium wilfordii liposome and its preparation and application

ActiveCN118078778BImprove stabilityGood sustained release effectIntrahepatic CholangiocarcinomaReceptor
The present invention discloses a tripterygium wilfordii nanoliposome, which is composed of a liposome core and an outer layer of wrapping material, wherein the liposome core contains a lipid material, TPP-TPGS and tripterygium wilfordii, and the wrapping material is hyaluronic acid, wherein the hyaluronic acid can actively target the overexpressed CD44 receptor on the surface of tumor cells, thereby increasing the accumulation of the drug carried in the tumor site, and the TPP-TPGS can further deliver the drug to the mitochondria, thereby increasing the active oxygen content of tumor cells, reducing the mitochondrial membrane potential, destroying the mitochondrial function, and further causing apoptosis. Therefore, the liposome is a tumor cell and mitochondrial dual-level targeting liposome, which is beneficial to reducing the toxicity of tripterygium wilfordii and improving the efficacy of the drug against intrahepatic cholangiocarcinoma.
Owner:HUBEI UNIV OF CHINESE MEDICINE

Tumor chemotherapy nursing method and device

The invention relates to the field of medical nursing equipment, in particular to a tumor chemotherapy nursing method and device.According to the method, in the chemotherapy drug infusion process, limbs of a patient are pressurized or cooled to increase flowing of blood of the limbs towards the center end; the equipment comprises a monitoring system, an execution liquid air bag, an air pressure control system and a liquid temperature control system. The air pressure control system comprises a pressurization system which is connected with the execution liquid air bag. The liquid temperature control system comprises a liquid accumulation box, a refrigeration unit and a heating unit, and the liquid accumulation box is connected with the execution liquid air bag; the refrigeration unit and the heating unit are arranged in the liquid accumulation box; the monitoring system comprises a monitoring unit and a control unit, and the control unit controls the gas pressure provided by the pressurization system and the liquid temperature provided by the liquid accumulation box according to monitoring parameters of the monitoring unit. The execution liquid air bag can be pressurized or cooled so as to increase flowing of limb blood towards the center end, and therefore accumulation of chemotherapeutic drugs in four-limb nerves is reduced.
Owner:PEKING UNIVERSITY FIRST HOSPITAL (PEKING UNIVERSITY FIRST CLINICAL MEDICAL COLLEGE)

Tumor-targeted activatable nano photosensitizer as well as preparation method and application thereof

The invention discloses a tumor targeting activatable nano photosensitizer as well as a preparation method and application thereof. The tumor targeting activatable nano photosensitizer comprises a cationic polymer, an anionic polymer and an aromatic structure photosensitizer. Cationic-pi interaction is formed between a cationic side chain in the cationic polymer and the photosensitizer with an aromatic structure, the nano photosensitizer is formed through self-assembly under the interaction, and the photosensitive activity of the nano photosensitizer in blood circulation is in a completely inactivated state; and no light toxic or side effect is generated on normal light exposure tissues. When selectively enriched in tumor tissues, the photosensitizer is structurally degraded in tumor cells in a specific environment, and the photosensitive activity of the photosensitizer is quickly activated and recovered, so that efficient tumor inhibition treatment is realized.
Owner:SOUTHERN MEDICAL UNIVERSITY