The invention discloses a central air conditioner intelligent control system based on a wireless sensor network and a method, and belongs to the technical field of central air conditioner control. The central air conditioner intelligent control system comprises an intelligent information management center, wireless communication devices, a central air conditioner information monitoring and control module, a room information monitoring and control module and the like. The invention adopts the method that the central air conditioner intelligent control system is used to monitor information, build a data base, calculate current load of the system, and realize advance, accurate and optimized control of a central air conditioner system by combining a short-term loading forecasting method based on similar dates and fuzzy control technology, as well as taking the temperature variation of supply/return chilled/cooling water of a central air conditioner as the manipulated variable. The central air conditioner intelligent control system has the characteristics of great communication capacity, guaranteed communication quality, powerful network functions, wide monitoring range and extensive control quantity of the central air conditioner system, optimized control, high control accuracy, good energy saving effect and the like, and can be widely used in energy-saving optimizing control of various buildings, and is particularly suitable for energy-saving optimizing control of central air conditioners of intelligent buildings.