The present invention belongs to the field of food producing technology, and is especially production process of nutritious sea food wine, which is produced with grain liquor as the base material, abalone and sea cucumber as main material, and wolfberry fruit, Chinese yam, licorice, cassia bark, date, mulberry and kudzu vine root as supplementary material. The production process includes the following steps: 1. cooking fresh abalone and sea cucumber, puffing in dilute base solution, freeze drying, crushing, sieving and sterilizing to obtain abalone and sea cucumber powder; 2. washing and drying the supplementary material, crushing, sieving and sterilizing to form supplementary material powder; and 3. soaking the abalone and sea cucumber powder and the supplementary material powder separately in grain liquor for several days, filtering to obtain filtrates, mixing, heating to eliminate alcohol, homogenizing, filtering, seasoning, sterilizing and packing.