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Preparation method of non-enzyme electrochemical glucose sensor

A glucose and electrochemical technology, applied in the direction of electrochemical variables of materials, scientific instruments, instruments, etc., can solve the problem of glucose sensor not being able to detect glucose, and achieve the effects of reducing impact, large application range, and simple and effective synthesis process.

Active Publication Date: 2017-01-04
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The present invention aims to solve the problem that the existing glucose sensor cannot perform enzyme-free electrochemical glucose detection under neutral and partial neutral conditions, and provides a preparation method of an enzyme-free glucose electrochemical sensor

Method used

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  • Preparation method of non-enzyme electrochemical glucose sensor
  • Preparation method of non-enzyme electrochemical glucose sensor
  • Preparation method of non-enzyme electrochemical glucose sensor

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specific Embodiment approach 1

[0030] Specific embodiment one: the preparation method of the enzyme-free glucose electrochemical sensor of this embodiment is carried out according to the following steps:

[0031] 1. Grinding and cleaning the electrode: put the polishing powder and deionized water on the grinding disc and mix thoroughly to obtain a polishing solution, then polish the glassy carbon electrode in the polishing solution, and then use acetone, absolute ethanol and deionized water to clean the glassy carbon The electrode is ultrasonically cleaned to remove surface oil and impurities to obtain a cleaned glassy carbon electrode;

[0032] 2. Detection of electrode performance: After cleaning, the glassy carbon electrode should record 0.5-3mM K in 0.1-2mol / L KCl 3 [Fe(CN) 6 ]+0.5~3mM K 4 [Fe(CN) 6 ] The cyclic voltammetry curve of the solution, observe and calculate the peak potential difference in the cyclic voltammogram, if the peak potential difference is 64-80mV, proceed to the next step; The ...

specific Embodiment approach 2

[0039] Embodiment 2: This embodiment is different from Embodiment 1 in that: the particle size of the polishing powder in step 1 is 0.3 microns. Others are the same as in the first embodiment.

specific Embodiment approach 3

[0040]Embodiment 3: This embodiment differs from Embodiment 1 or Embodiment 2 in that: the grinding disc in step 1 is made of suede. Others are the same as in the first or second embodiment.

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Abstract

The invention relates to a preparation method of a glucose sensor, and in particular to a preparation method of a non-enzyme electrochemical glucose sensor, aiming at solving the problem that the existing glucose sensor cannot carry out non-enzyme electrochemical glucose detection under the neutral and partial neutral conditions. The method comprises the steps of 1, grinding and cleaning an electrode; 2, detecting the performance of the electrode; 3, synthesizing: dissolving Co(NO3)2 6H2O in methyl alcohol, and stirring for dissolving to obtain a solution A; dissolving dimethyl imidazole in the methyl alcohol, and stirring for dissolving to obtain a solution B; then, mixing the solution A with the solution B, and standing; 4. cleaning and drying to obtain a metal-organic framework material ZIF-67; 5, carrying out heat treatment; 6, adding black powder into a solvent to obtain suspension liquid, carrying out ultrasonic treatment on the suspension liquid, adding the treated suspension liquid onto the surface of the glassy carbon electrode drop by drop, and drying to obtain the non-enzyme electrochemical glucose sensor. The non-enzyme electrochemical glucose sensor can carry out non-enzyme electrochemical glucose detection under the neutral and partial neutral conditions, and is simple and practicable as well as low in cost. The non-enzyme electrochemical glucose sensor is used for detecting glucose.

Description

technical field [0001] The invention relates to a preparation method of a glucose sensor. Background technique [0002] The effective and rapid detection of glucose plays an important role in biology, food, chemistry, clinical diagnosis and environmental protection. There have been many reports on the research on the enzyme-free electrochemical detection of glucose, because the enzyme-free electrochemical sensor has a good Features such as stability, repeatability and simplicity. Therefore, the research of glucose sensor has always been a hotspot of electrochemical sensor research. [0003] Structurally, metal-organic frameworks (MOFs) are very similar to inorganic molecular sieves, with regular topology and pores of specific shapes and sizes. However, the pore size of MOFs is self-assembled by metal ions and organic ligands through coordination bonds. Because of the rich variety of synthetic raw materials, different metal ions have different oxidation states or geometric ...

Claims

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Application Information

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IPC IPC(8): G01N27/30G01N27/48G01N27/26
CPCG01N27/26G01N27/30G01N27/308G01N27/48
Inventor 杨敏褚宏旗徐慧芳解秀秀
Owner HARBIN INST OF TECH
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