Preparation method for copper oxide-graphene nano-complex modification electrode, and application of modification electrode in glucose detection

A nano-composite and modified electrode technology, applied in the field of electrochemical analysis and detection, can solve the problem of not preparing a glucose sensor, and achieve the effects of avoiding enzyme inactivation and instability, improving sensitivity and easy operation.

Inactive Publication Date: 2012-06-27
SHANGHAI UNIV
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Problems solved by technology

So far, the composite of the two has not been used as a sensitive material to prepare a glucose sensor

Method used

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  • Preparation method for copper oxide-graphene nano-complex modification electrode, and application of modification electrode in glucose detection
  • Preparation method for copper oxide-graphene nano-complex modification electrode, and application of modification electrode in glucose detection
  • Preparation method for copper oxide-graphene nano-complex modification electrode, and application of modification electrode in glucose detection

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Embodiment

[0022] The preparation method and steps of the modified glassy carbon electrode in the present embodiment are as follows:

[0023] (1) Pretreatment of glassy carbon electrodes: firstly, glassy carbon electrodes, i.e. glassy carbon electrodes, were treated with 1.0, 0.3, 0.05 μm Al 2 o 3 The polishing powder sequentially grinds and polishes the glassy carbon electrode to a mirror surface, then ultrasonically cleans it with ultrapure water, dilute nitric acid solution, absolute ethanol and ultrapure water, and dries for use;

[0024](2) Preparation of copper oxide-graphene nanocomposite modified electrode: first, graphene was prepared by the steps of oxidation, exfoliation and chemical reduction of graphite using the improved Hummers method. The specific steps are as follows: assemble the reaction bottle in an ice-water bath, add an appropriate amount of concentrated sulfuric acid, add a certain amount of graphite powder and an appropriate amount of solid mixture of sodium nitr...

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Abstract

The present invention relates to a preparation method for a copper oxide-graphene nano-complex modification glassy carbon electrode, and an application of the electrode as a glucose electrochemical sensor in rapid glucose detection, and belongs to the technical field of electrochemical analysis detection. According to the present invention, an electrochemical catalytic oxidation effect is adopted, and a current-time curve method is adopted to carry out sensitive quantitative analysis determination on the glucose, wherein the electrochemical catalytic oxidation effect is provided by the glucose sensor, and the copper oxide-graphene nano-composite material is adopted to modify the glassy carbon electrode to prepare the glucose sensor. The key point of the invention is: coating a naphthol suspension of the graphene on the surface of the treated glassy carbon electrode in a dropwise manner; carrying out open-air drying to form a layer of uniform modification layer; and adopting an electrodeposition method with a characteristic of simple operation to prepare a sensitive layer of the copper oxide-graphene nano-complex to achieve the stable catalysis of the glucose oxidation. The prepared glucose sensor of the present invention can be used clinically in detection analysis of blood glucose content in serum, and the determination process has characteristics of rapidness, sensitivity, accuracy, stability, low interference and the like.

Description

technical field [0001] The invention relates to the preparation of a glassy carbon electrode modified by a copper oxide-graphene nanocomposite and its application as an electrochemical glucose sensor for clinical rapid determination of blood sugar, which belongs to the technical field of electrochemical analysis and detection. Background technique [0002] Carbon is a wonder material with a wide range of applications, including both the hardest diamond in the world and the softest graphite. In the past two decades, research on carbon nanomaterials has been at the forefront of technological innovation. In 2004, British scientists discovered that the sp 2 Graphene, a new type of two-dimensional atomic crystal composed of hybrid-connected monoatomic layers, is currently the most ideal two-dimensional nanomaterial. Graphene is composed of carbon atoms on a dense layer of crystal lattice, and its thickness is only 0.35 nm, which is the thinnest two-dimensional material in the w...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/30G01N27/327
Inventor 罗立强朱丽梅李芳丁亚平王振新李丽
Owner SHANGHAI UNIV
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