Method for extracting shaddock ped aglycone from shaddock

A technology for extracting naringin and water, which is applied in the field of extracting naringin monomer, and achieves the effects of simple extraction process, high purity and high extraction yield

Inactive Publication Date: 2004-09-15
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The method for extracting naringin monomer from medicina

Method used

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  • Method for extracting shaddock ped aglycone from shaddock

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Embodiment 1

[0024] Cut the young fruit of Shatian pomelo into decoction pieces, add 100°C water to submerge the medicinal materials, extract three times with water, one hour each time, and filter; the filtrate is concentrated into an extract, passed through a macroporous resin column, washed with water, and then washed with 70% ethanol Elution: collect the ethanol eluent, recover ethanol from the eluent, obtain a precipitate, recrystallize the precipitate three times with water, and spray dry to obtain naringin monomer. The yield was 88.6%.

Embodiment 2

[0026] Pulverize the pomelo peel of Shatian pomelo, do not sieve, add 100°C water to submerge the sample, extract three times, each time for 1 hour, filter, combine the filtrate; concentrate the filtrate, add absolute ethanol until the ethanol concentration is 50%, let stand overnight, filter , and the supernatant was recovered with ethanol. Pass the extract through a polyamide column, elute with water first, and then elute with 30% ethanol; collect the ethanol eluate, recover ethanol from the eluate, obtain a precipitate, dry the precipitate, and recrystallize five times with absolute ethanol to obtain pomelo dermoside monomer. The yield was 86.3%.

Embodiment 3

[0028] The young fruit of Shatian pomelo is cut into decoction pieces, extracted twice by 70°C water for 3 hours each time, filtered, and the filtrate is combined; the filtrate is concentrated into an extract, and the extract is added with 95% ethanol until the ethanol concentration is 60%, and left to stand Overnight, a precipitate was produced, filtered, and the precipitate was removed. The filtrate recovered ethanol, and the obtained liquid aluminum peroxide column was eluted with water first, and then 95% ethanol; the ethanol eluate was collected, recovered and concentrated, and the precipitate was obtained. Recrystallize four times to get naringin monomer. The yield was 85.8%.

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Abstract

The invention relates to a method to extract naringin monomer from pomelo (like Shatian pomelo), slicing up or crush pomelo, extracting by water for one or many times, filtering and combining filtrates; condensing the filtrate into extract, applying the extract on column after alcohol deposition or directly, making column separation, and eluting by organic solvent; volatilize the solvent from the eluent to obtain rough product; then recrystallizing for many times to obtain naringin crystal. The extraction yields of naringin from Shatian pemelo are all above 85% and the naringin monomer content in the obtained naringin sample reaches above 98%.

Description

technical field [0001] The invention relates to a method for extracting naringin monomer from pomelo Citus grandis (L) Osbeck (such as Shatian pomelo, etc.). Background technique [0002] Naringin is a flavonoid compound widely present in various Chinese herbal medicines, such as Citrus aurantium, Citrus aurantium, citrus, lemon, grapefruit, tangerine, orange, etc. Naringin is also contained in grapefruit Citus grandis (L) Osbeck, and the content is relatively high. Pomelo Citus grandis (L) Osbeck has many varieties, including Wendan pomelo Citus grandis (L) Osbeck var.wentanyu Hort., Shatian pomelo Citus grandis (L) Osbeckv var.shatianyu Hort., Pingshan pomelo Citus grandis (L) Osbeck var.Hort., Citus grandis(L) Osbeck var.szechipow Hort. for four seasons, Citus grandis(L) Osbeck var.tahungpow. for big red. Naringin is one of the main active ingredients of various medicinal materials. Studies have proved that naringin has antibacterial and anti-inflammatory effects, reli...

Claims

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Application Information

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IPC IPC(8): C07H1/08C07H17/07
Inventor 苏薇薇方铁铮吴忠宋晓虹王永刚彭维古淑仪
Owner SUN YAT SEN UNIV
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