Near-infrared on-line detection method used in production process of traditional Chinese medicine containing naringin

A production process and detection method technology, applied in the direction of measuring devices, material analysis through optical means, instruments, etc., can solve the problems of inability to solve the quality control problems of key process links, the lack of rapid and non-destructive determination methods for active ingredient content, etc., to achieve effective Conducive to the whole process control, improve the stability of product quality, and the effect of strong predictive ability

Active Publication Date: 2014-09-24
广东省中医药工程技术研究院
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Problems solved by technology

[0003] At present, the production process of traditional Chinese medicine containing naringin lacks a rapid and non-destructive determination method for the content of active ingredients, which cannot solve the quality control problems of key process links, making it difficult to solve the stability and reliability of Yinlantiaozhi capsule technology and ingredients from the source of the product.

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  • Near-infrared on-line detection method used in production process of traditional Chinese medicine containing naringin
  • Near-infrared on-line detection method used in production process of traditional Chinese medicine containing naringin
  • Near-infrared on-line detection method used in production process of traditional Chinese medicine containing naringin

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Embodiment 1

[0039] The near-infrared spectrometer selected in this embodiment is the Luminar3060 acousto-optic tunable online near-infrared spectrometer (No. 1112-SP-10979) from Brimrose Company of the United States. The main components include: optical part, control part, 675 transflective probe, DN25 fluid sample device, optical fiber and other components. The detector used in the instrument is InGaAs. The extraction, concentration, ethanol precipitation, and ethanol recovery equipment used in the production process of Yinlantiaozhi Capsules in this example is the automation equipment of Guangzhou Baiyunshan Hanfang Modern Pharmaceutical Co., Ltd. The material mixing process uses a Nicolet6700 Fourier transform infrared spectrometer (Thermo Nicolet, USA), equipped with an integrating sphere diffuse reflectance sampling system and Omnic signal acquisition software. The present embodiment also relates to Agilent1200 high performance liquid chromatograph, Mettler XS205DU type electronic a...

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Abstract

The invention provides a near-infrared on-line detection method used in production process of a traditional Chinese medicine containing naringin. The method comprises the following steps: collecting a sample in the production process of the traditional Chinese medicine containing naringin, and acquiring a near-infrared spectrum of the sample; measuring the content of naringin in the sample by using the existing technology; establishing a detection model by using chemometrics software according to the near-infrared spectrum of the sample and the naringin content measured by using the existing technology, wherein the spectrum range of the near-infrared spectrum of the detection model is 1100-2300nm; and acquiring the sample to be detected, and measuring the content of naringin and the spectrum similarity degree by using the detection model. By adopting the near-infrared on-line detection method used in the production process of the traditional Chinese medicine containing naringin, the problems that a quality analysis method is low in efficiency and too many raw materials are wasted in the production process of the traditional Chinese medicine containing naringin are effectively solved.

Description

technical field [0001] The invention belongs to the technical field of extraction and preparation of traditional Chinese medicines, and in particular relates to a near-infrared online detection method in the production process of traditional Chinese medicines containing naringin. Background technique [0002] The production of traditional Chinese medicine compound preparations is a complex manufacturing process. During the production process, different raw material bases and changes in various process parameters can lead to unstable quality of the final product. Quality control in the production process mainly relies on experience and traditional quality analysis methods, and lacks effective real-time monitoring methods for the content of index components. In actual production, the extraction time is often fixed, basically regardless of the difference in the quality of raw materials and the fluctuation of working conditions, the extraction end point is advanced or delayed, w...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/359
Inventor 涂瑶生孙冬梅王洛临毕晓黎陈玉兴李智勇
Owner 广东省中医药工程技术研究院
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