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Method for simultaneously extracting synephrine and flavonoids from immature bitter oranges

A technology for flavonoids and citrus aurantium is applied in the field of simultaneous extraction of synephrine and flavonoids from citrus aurantium, which can solve the problems of less extraction and separation of components and the like

Inactive Publication Date: 2016-07-13
HUNAN UNIV OF CHINESE MEDICINE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing technology can separate one or two components and use them for industrial production, and the extraction and separation of two or more components is less

Method used

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  • Method for simultaneously extracting synephrine and flavonoids from immature bitter oranges

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Experimental program
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Embodiment 1

[0035] The method for simultaneously extracting synephrine and flavonoids from Citrus aurantium provided by the embodiments of the present invention comprises:

[0036] S101: Clean and dry the Fructus Fructus Aurantii, and crush the Fructus Fructus Aurantii after drying into a coarse powder with a particle size of 0.1 mm;

[0037] S102: putting the coarse powder into an ethanol solution containing sodium hydroxide for extraction to obtain an extract;

[0038] S103: Use 3% hydrochloric acid to adjust the pH of the extract to neutral, let stand, precipitate, dry the precipitate under reduced pressure to obtain hesperidin, and set the filtrate for later use;

[0039] S104: concentrating the filtrate through an ultrafiltration membrane to obtain a first concentrated solution;

[0040] S105: Concentrate the first concentrated solution under vacuum and reduced pressure at a temperature of 55° C. to a relative density of 1.05 to obtain a second concentrated solution;

[0041] S106:...

Embodiment 2

[0048] The method for simultaneously extracting synephrine and flavonoids from Citrus aurantium provided by the embodiments of the present invention comprises:

[0049] S201: Clean and dry the Fructus Fructus Aurantii, and crush the Fructus Fructus Aurantii after drying into a coarse powder with a particle size of 0.5 mm;

[0050] S202: putting the coarse powder into an ethanol solution containing sodium hydroxide for decoction and extraction to obtain an extract;

[0051] S203: Use 6% hydrochloric acid to adjust the pH of the extract to neutral, let stand, precipitate, dry the precipitate under reduced pressure to obtain hesperidin, and set aside the filtrate;

[0052] S204: Concentrating the filtrate through a nanofiltration membrane to obtain a first concentrated solution;

[0053] S205: Concentrate the first concentrated solution under vacuum and reduced pressure at a temperature of 65° C. to a relative density of 1.05-1.2 to obtain a second concentrated solution;

[005...

Embodiment 3

[0061] The method for simultaneously extracting synephrine and flavonoids from Citrus aurantium provided by the embodiments of the present invention comprises:

[0062] S301: Clean and dry the Fructus Fructus Aurantii, and crush the Fructus Fructus Aurantii after drying into a coarse powder with a particle size of 0.3 mm;

[0063] S302: mixing sodium hydroxide with an ethanol solution with a concentration of 50% to form a mixed solution with a concentration of 1%, putting the coarse powder into the mixed solution for cold extraction to obtain an extract;

[0064] S303: Use 3% hydrochloric acid to adjust the pH of the extract to neutral, let stand, precipitate, dry the precipitate under reduced pressure to obtain hesperidin, and set aside the filtrate;

[0065] S304: Concentrating the filtrate through an ultrafiltration membrane to obtain a first concentrated solution;

[0066] S305: Concentrate the first concentrated solution under vacuum and reduced pressure at a temperature...

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Abstract

The invention provides a method for simultaneously extracting synephrine and flavonoids from immature bitter oranges. The method comprises the steps as follows: the immature bitter oranges are smashed and extracted, acid is added to an extract for precipitation, and hesperidin is obtained; a precipitated filtrate is subjected to three steps of concentration including ultrafiltration membrane concentration and / or nanofiltration membrane concentration, vacuum decompression concentration and flue gas concentration, then a condensed extract is obtained, and is subjected to extraction, mixing with petroleum ether, crystallization and suction filtration, and then synephrine is obtained; the suction filtration liquid after suction filtration is condensed and mixed with ethanol, mixed liquor is formed and treated by macroporous adsorption resin, and neohesperidin and naringin are obtained. The ultrafiltration membrane concentration and / or nanofiltration membrane concentration and the flue gas concentration adopted by the method for simultaneously extracting synephrine and flavonoids from the immature bitter oranges can all reduce energy consumption, so that the solvent recovery rate is increased, and the filtrate treatment cost is lowered; differences between synephrine and other flavonoids in an extracting agent are used for separation and purification, therefore, the production process can be simplified, the production cost can be lowered, and the resource utilization rate can be increased.

Description

technical field [0001] The invention relates to the technical field of medicine extraction, and more specifically relates to a method for simultaneously extracting synephrine and flavonoids from Citrus aurantium. Background technique [0002] Citrus aurantium is a commonly used traditional Chinese medicine, which is the dried young fruit of Rutaceae plant sour orange and its cultivars or sweet orange. Citrus aurantium is bitter, pungent, sour and warm in nature, and it returns to the spleen, stomach and large intestine meridian. , constipation, stagnation of phlegm and air obstruction, chest obstruction, chest knots, visceral sagging and other symptoms. Citrus aurantium has many chemical components, and its main active components are volatile oil, flavonoids and alkaloids. [0003] Among them, synephrine has a higher content in alkaloid compounds, and synephrine belongs to ephedrine compounds. Its molecular structure contains phenolic hydroxyl and amino groups, so it has a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C213/10C07C215/60C07H17/07C07H1/08
CPCC07C213/10C07H1/08C07H17/07C07C215/60
Inventor 李顺祥饶洁黄丹易成玉李娟张红刚徐菲严建业覃丽
Owner HUNAN UNIV OF CHINESE MEDICINE
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