Composition for curing gastrointestinal functional disorders, preparation method thereof and application thereof in preparing drugs for curing gastrointestinal functional disorders

A technology for gastrointestinal dysfunction and composition, which is applied in the field of compositions for treating gastrointestinal dysfunction, and can solve unseen problems and the like

Active Publication Date: 2010-01-13
山东花王粮油集团有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no research on the active ingredient group extract and active ingredients isolated from the compound composed of Radix Paeoniae Alba, Bupleurum, Fructus Citrifolia, and Licorice

Method used

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  • Composition for curing gastrointestinal functional disorders, preparation method thereof and application thereof in preparing drugs for curing gastrointestinal functional disorders
  • Composition for curing gastrointestinal functional disorders, preparation method thereof and application thereof in preparing drugs for curing gastrointestinal functional disorders
  • Composition for curing gastrointestinal functional disorders, preparation method thereof and application thereof in preparing drugs for curing gastrointestinal functional disorders

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0054] Experimental Example 1. Effects of Drugs on Mice with Spleen Deficiency

[0055] 1. Animals and grouping: 70 male Kunming mice, weighing 18-22 g, were randomly divided into 7 groups, and each group was fed with 10 mice.

[0056] 2. Administration and experimental methods: Except for the normal control group, all other groups were given 200% rhubarb water decoction, 0.25ml·10g~1, for 10 consecutive days to replicate the mouse model of spleen deficiency. Since the 5th day after administration of rhubarb water decoction, each group was administered by intragastric administration for 6 days. The mice were fasted for 18 hours before the experiment, and 30 minutes after the last administration, the mice were gavaged with 5% Evans blue solution, and the gastrointestinal tract was taken out after the mice were killed, and the distance from the front of the Evans blue to the pylorus was recorded, and its percentage of the small intestine was calculated. long percentage. The th...

experiment example 2

[0064] Experimental Example 2. Regulatory Effects of Drugs on Gastrointestinal Disorders in Rats Induced by Reserpine

[0065] 1. Animals and grouping: 60 healthy adult male SD rats were randomly divided into 6 groups, and 10 rats were raised in each group.

[0066] 2. Administration and experimental methods: (1) normal control group was injected with normal saline intraperitoneally, and distilled water was fed at the same time; (2) gastrointestinal dysfunction model group: reserpine was injected intraperitoneally at 0.5 mg·kg~1, and at the same time fed with Distilled water; (3) Positive group: intraperitoneal injection of reserpine, and at the same time, gavage of Suliqineng; (4) active ingredient group extract group: intraperitoneal injection of reserpine 0.5mg kg~1, and gavage of active ingredient group extract High and low doses. Each group was administered continuously for 14 days. The feces and signs of the rats were observed at any time, and the body weight and food ...

experiment example 3

[0071] The regulation effect of Experimental Example 3 on intestinal flora disorder

[0072] 1. Animals and grouping: 50 Kunming mice, weighing 18-22 g, were randomly divided into 5 groups, and 10 mice were raised in each group.

[0073] 2. Dosing and experimental methods: (1) The normal control group was given intragastric administration of equal volume of distilled water; (2) Model group: daily oral administration of rhubarb liquid 1g / piece; (3) Compound decoction group: daily oral administration of rhubarb Drug solution 1g / carp intraperitoneally, at the same time gavage compound decoction; (4) active ingredient group extract group: daily gavage rhubarb liquid 1g / carp, and simultaneously gavage high and low doses of active ingredient group extract. After 5 consecutive days, the abdominal cavity was opened under aseptic conditions, and the formed feces in the intestine were collected. Dilute the feces with Bifidobacterium and Lactobacillus liquid culture medium to a concentr...

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Abstract

The invention relates to a composition for curing gastrointestinal functional disorders, a preparation method thereof and an application thereof in preparing drugs for curing the gastrointestinal functional disorders. The bulk drugs of the composition comprise radix bupleuri, radix glycyrrhizae preparata, fruit of immature citron and white paeony root, which follow a weight proportion of 6:6:6:6-9. The composition comprises the following components by weight percent: 24.5-46.5% of total flavonoids, 10.5-31.6% of total saporins, 17.0-35.4% of naringin, 1.1-8.5% of glycyrrhizic acid and 3.2-13.7% of paeoniflorin. The preparation method is as follows: condensing water solution of the bulk drugs; using macroporous absorption resin for absorption, continuing to wash till the state of colorlessness after the water solution completely passes through a resin column; using 50-85% by weight of ethanol for elution, and collecting eluent; reducing the pressure of solvent, recovering the solvent, drying the solvent, and finally obtaining the composition. Compared with decoction and western medicines, the extract of the composition achieves better and more obvious effect in curing the gastrointestinal functional disorders.

Description

technical field [0001] The present invention relates to a composition (Chinese medicine compound extract) for treating gastrointestinal dysfunction, a preparation method and its application in the preparation of medicines for treating gastrointestinal dysfunction or anti-irritable bowel syndrome (IBS). The extract can be used For the treatment of gastrointestinal disorders, especially for the treatment of irritable bowel syndrome. Background technique [0002] Gastrointestinal dysfunction is a common clinical functional intestinal disease, accounting for about 40-60% of gastrointestinal diseases. Among them, the prevalence of irritable bowel syndrome (IBS) in adults is 10% to 22%, and it is slightly more common in women. Its main clinical manifestations are abdominal pain, diarrhea, constipation and other digestive system symptoms without organic lesions, and its etiology is gastrointestinal dysfunction. [0003] With the acceleration of people's life rhythm, the prevalenc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/752A61P1/00
Inventor 杨星昊吴剑波郭升
Owner 山东花王粮油集团有限公司
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