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A naringin solid dispersion and the preparation method, and the application thereof

A technology of solid dispersion and naringin, which is applied in the field of naringin solid dispersion and its preparation and application, can solve the problems of low water solubility and poor absorption of naringin, and achieves improved bioavailability and good absorption. , the effect of improving solubility and in vitro dissolution rate

Active Publication Date: 2009-09-30
广东伯克生物医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to solve the problem of low water solubility and poor absorption of naringin in the prior art, and provide a kind of naringin solid dispersion which obviously improves the water solubility of naringin and has higher bioavailability

Method used

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  • A naringin solid dispersion and the preparation method, and the application thereof
  • A naringin solid dispersion and the preparation method, and the application thereof
  • A naringin solid dispersion and the preparation method, and the application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0032] Embodiment 1 Solid dispersion carrier material, ratio and preparation experiment

[0033] In this example, the effects of the ratio of naringin and carrier material, the type of carrier material, and the preparation method on the preparation of solid dispersion were studied. According to the following table 1 and table 2 for research:

[0034] Table 1 Factor and level table

[0035]

[0036] Table 2 Orthogonal test table

[0037]

[0038] Test No. 1: Dissolve 600mg of naringin monomer compound in 20ml of absolute ethanol, then dissolve 1.2g of PVPK30 in 100ml of absolute ethanol, mix the PVPK30 solution and naringin solution, and then vigorously stir to mix, using The organic solvent was removed by rotary evaporation, and after the mixture became viscous, it was rapidly cooled and solidified, placed in a vacuum oven at 25°C for 48 hours, and ground to obtain a solid dispersion.

[0039] Test No. 2: Dissolve 600mg of naringin monomer compound in 20ml of absolute...

Embodiment 2

[0048] Embodiment 2 Preparation of naringin solid dispersion

[0049] Dissolve 600mg of naringin monomer compound in 20ml of absolute ethanol, then dissolve 1.2g of PEG6000 and 600mg of sodium dodecylsulfonate in 150ml of absolute ethanol, mix the mixed carrier material solution and naringin solution, and then vigorously Stir to mix evenly, and remove the organic solvent by rotary evaporation. After the mixture becomes viscous, it is rapidly cooled and solidified, placed in a vacuum oven at 25°C for 48 hours, ground, and passed through a 60-mesh sieve to obtain a solid dispersion.

Embodiment 3

[0050] Embodiment 3 Preparation of naringin solid dispersion

[0051] Dissolve 600mg of naringin monomer compound in 20ml of 95% ethanol, then dissolve 1.8g of PVP K30 and 600mg of Poloxamer 188 in 150ml of absolute ethanol, mix the mixed carrier material solution and naringin solution, and then vigorously stir to mix , using rotary evaporation to remove the organic solvent, and after the mixture was in a viscous state, it was rapidly cooled and solidified, placed in a vacuum oven at 25°C for 48 hours, ground, and passed through an 80-mesh sieve to obtain a solid dispersion.

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Abstract

The invention discloses a naringin solid dispersion, and the preparation method and the application thereof. The naringin solid dispersion contains naringin and vector material. The mass ratio of naringin and the vector material is 1:2 to 1:5. The vector material is any one of or any mixture of polyethylene glycol, polyvinyl pyrrolidone and poloxamer. The preparation method of the naringin solid dispersion is to get the naringin, the vector material and the other regular auxiliary materials by melting method, solvent method, solvent-melting method, spray drying method or freeze-drying method. The application of the naringin solid dispersion is to apply in preparing pharmaceutical preparations or healthfood. The invention of the naringin solid dispersion is to disperse naringin by solid dispersion technique, which improves the solubility in water and dissolution rate in vitro and at the same time enhances the bioavailability.

Description

technical field [0001] The invention relates to a naringin solid dispersion and its preparation method and application. Background technique [0002] Solid dispersions mainly use water-soluble polymer materials as carriers, and surfactants can also be added according to the situation. Using melting method, solvent method and solvent-melting method, insoluble drugs are dispersed in another solid in the form of amorphous crystals. in the carrier. It can not only maintain the high dispersibility of the drug in the carrier, make the drug have good wettability, improve the dissolution rate and solubility of poorly soluble drugs, and promote drug absorption, but also can be used as an intermediate for immediate release or sustained release preparations and enteric-coated preparations. body. [0003] Naringin is a kind of flavonoid compound, and it is one of the main active ingredients of various medicinal materials such as Citrus aurantium, Fructus aurantium and Citrus aurantium...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K47/32A61K47/34A61K31/7048A61P3/06A61P3/10A61P9/10A61P11/10A61P11/14A61P29/00A61P31/10A61P35/00A61P39/06A23L1/30A23L33/105A61K47/10
Inventor 苏薇薇方思琪王永刚彭维李沛波杨翠平
Owner 广东伯克生物医药有限公司
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