Quality detection method of fallopia multiflora (thunb.) harald-aloe constipation relieving capsules

A Shouhui laxative and capsule technology, applied in measuring devices, instruments, scientific instruments, etc., can solve the problems of constipation, high recurrence rate, obvious side effects of drugs, etc., to meet the needs of medical treatment and the market, Controllable conditions, scientific and reasonable detection methods

Active Publication Date: 2016-11-16
LUNAN HOPE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Conventional drug treatment, hydrotherapy enema and surgical therapy of Western medicine can temporarily relieve the clinical symptoms of functional constipa...

Method used

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  • Quality detection method of fallopia multiflora (thunb.) harald-aloe constipation relieving capsules
  • Quality detection method of fallopia multiflora (thunb.) harald-aloe constipation relieving capsules
  • Quality detection method of fallopia multiflora (thunb.) harald-aloe constipation relieving capsules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Example 1 HPLC methodological study of 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside

[0044] 1) Drugs and reagents: 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside reference substance 0081-9304 (National Institute for the Control of Pharmaceutical and Biological Products), acetonitrile and methanol as chromatographic Pure, other reagents were analytically pure, and water was double distilled water.

[0045] 2) Instrument: AgiLent 1100 high performance liquid chromatograph, VWD detector.

[0046] 3) Chromatographic conditions: chromatographic column: KromasiL C18 chromatographic column (4.6mm×250mm, 5μm); mobile phase: acetonitrile-methanol-water (20:8:72); detection wavelength: 320nm; flow rate: 1mL / min.

[0047] 4) Solution preparation

[0048] 4.1) Comparison and determination of sample pretreatment methods

[0049] 4.1.1) Take the contents of Shouhui Laxative Capsules, grind it finely, take about 0.5g, weigh it accurately, put it in a conical flask, add 50mL wa...

Embodiment 2

[0082] Example 2 Research on the High Performance Liquid Phase Determination Methodology of Naringin

[0083] 1) Drugs and reagents: Naringin reference substance 110722-200610 (National Institute for the Control of Pharmaceutical and Biological Products), acetonitrile and methanol are chromatographically pure, other reagents are analytically pure, and water is double distilled water.

[0084] 2) Instrument: AgiLent 1100 HPLC, VWD detector

[0085] 3) Chromatographic conditions: chromatographic column: KromasiL C18 chromatographic column (4.6mm×250mm, 5μm); mobile phase: acetonitrile-0.1% phosphoric acid solution (20:80); detection wavelength: 283nm; flow rate: 1mL / min.

[0086] 4) Solution preparation

[0087] 4.1) Preparation of the test solution

[0088] Take the content of Shouhui Laxative Capsules, grind it finely, take about 0.7g, weigh it accurately, put it in a stoppered Erlenmeyer flask, add 25mL of methanol precisely, weigh it, treat it with ultrasound for 30 minutes,...

Embodiment 3

[0113] Example 3 TLC identification of ginseng in Shouhui Tongbian Capsules

[0114] 1) Preparation of the test solution: take 17g of the contents of the Shouhui laxative capsule, grind it finely, add 30mL of methanol for ultrasonic treatment for 30 minutes, filter, evaporate the filtrate to dryness, add 10mL of water to dissolve the residue, add 80mL of n-butanol and mix well , placed in a separatory funnel, washed 4 times with 5% sodium hydroxide solution, 30 mL each time, discarded the lye, then washed with n-butanol-saturated water until neutral, evaporated the n-butanol solution to dryness, and added 2 mL of methanol to the residue To dissolve, add 1g of alumina and mix well, evaporate the solvent, add to a neutral alumina column (100-200 mesh, 5g, inner diameter 1.5cm), elute with 30mL of water, evaporate the eluent to dryness, add 1mL of methanol to the residue To dissolve, as the test solution.

[0115] 2) Preparation of the reference substance solution: take another ...

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Abstract

The invention discloses a quality detection method of a Chinese traditional patent medicine fallopia multiflora (thunb.) harald-aloe constipation relieving capsules for treating constipation. According to the quality detection method, the ginseng, the citrus aurantium, the aloe and the donkey-hide gelatin in the preparation are identified through a thin layer chromatography method while the 2,3,5,4'-tetrahydroxyl diphenylethylene-2-O-beta-D-glucoside content of the fallopia multiflora (thunb.) herald and the naringin content of the citrus aurantium in the preparation are determined by using HPLC. According to the present invention, the quality detection method has characteristics of stability, reliability, strong specificity and good reproducibility; and with the method, the quality of the fallopia multiflora (thunb.) harald-aloe constipation relieving capsules can be completely and effectively controlled, the stability of the product quality is easily achieved, the clinical medication safety and effectiveness can be ensured, and the medical and market needs can be well met.

Description

technical field [0001] The invention relates to a quality detection method of Shouhui Tongbian Capsules, a Chinese patent medicine for treating constipation, and belongs to the field of analysis of traditional Chinese medicine preparations. Background technique [0002] Traditional Chinese medicine believes that constipation is caused by conduction failure in the large intestine. It is manifested as constipation of stool, prolonged defecation cycle, dry and hard stool, or not hard stool, but the stool is not smooth or there is a feeling of incomplete defecation. Constipation, as a common clinical symptom, can accompany the onset of various acute and chronic diseases and bring great inconvenience to the work and life of patients. Especially in elderly patients, it can induce cardiovascular and cerebrovascular diseases and increase the risk of colorectal cancer. morbidity and can lead to depression or anxiety, seriously affecting people's quality of life. [0003] Conventiona...

Claims

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Application Information

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IPC IPC(8): G01N30/90G01N30/02
CPCG01N30/02G01N30/90G01N2030/027
Inventor 张则平张贵民苏瑞强刘武占
Owner LUNAN HOPE PHARM CO LTD
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