Method for preparing rod-like imprinted polymer capable of efficiently separating naringin in water phase

A technology for imprinting polymers and naringin, which is applied in the fields of alkali metal compounds, chemical instruments and methods, alkali metal oxides/hydroxides, etc., and can solve problems such as easy loss in screening treatment, cumbersome grinding of powder polymers, etc. , to achieve the effect of improving selective recognition, efficient separation, and increasing load capacity

Inactive Publication Date: 2011-04-06
FUJIAN NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the obtained powder polymer needs to be tediously ground and sieved, a

Method used

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  • Method for preparing rod-like imprinted polymer capable of efficiently separating naringin in water phase
  • Method for preparing rod-like imprinted polymer capable of efficiently separating naringin in water phase
  • Method for preparing rod-like imprinted polymer capable of efficiently separating naringin in water phase

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Experimental program
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Effect test

Embodiment 1

[0034] Dissolve 10g of β-CD and 3.1g of NG in an appropriate amount of 10% dimethyl sulfoxide aqueous solution at 30°C, then add 7mL of cross-linking agent hexamethylene diisocyanate (HMDI) dropwise while stirring, for 30min Finish. After keeping the reaction at this temperature for 3 h, add 10 g of liquid paraffin containing 0.8 g of emulsifier (Tween 20:Span 80=1:3), stir rapidly for 10 min and then raise the temperature to 75°C, while reducing the stirring speed and stirring at a constant speed Reaction 10h. After the reaction, the product was filtered and washed thoroughly with methanol, distilled water and acetone in order to remove various impurities. Finally, the NG absorption peak at 283nm was detected in the washing solution with a UV photometer. After washing, the product was vacuum-dried to constant weight to obtain a rod-shaped molecularly imprinted cyclodextrin polymer. The rod-shaped molecularly imprinted cyclodextrin polymer has a large specific surface area ...

Embodiment 2

[0036] Dissolve 4g of hydroxypropyl cyclodextrin and 4.15g of naringin dihydrochalcone in an appropriate amount of 30% N,N-dimethylacetamide aqueous solution at 30°C, and then add 10mL of it dropwise while stirring. Joint agent lysine diisocyanate, 20min to complete. After keeping the reaction at 30°C for 5h, add 15g of liquid paraffin containing 0.3g of emulsifier (Tween 80:Span 40=1:5), stir rapidly for 10min and then raise the temperature to 60°C, while reducing the stirring speed and stirring at a constant speed Reaction 8h. After the reaction, the product was filtered and washed thoroughly with methanol, distilled water and acetone in order to remove various impurities. Finally, the NG absorption peak at 283nm was detected in the washing solution with a UV photometer. After washing, the product was vacuum-dried to constant weight to obtain a rod-shaped molecularly imprinted cyclodextrin polymer.

Embodiment 3

[0038]Dissolve 2g of γ-cyclodextrin and 0.5g of quercetin in an appropriate amount of 20% N,N dimethylacetamide aqueous solution at 30°C, then add 6mL of cross-linking agent toluene diisocyanate dropwise while stirring, and complete in 20 minutes . After keeping the reaction at this temperature for 1 h, add 10 g of aviation kerosene containing 0.4 g of emulsifier (Tween 20: Span 20 = 1: 10), stir rapidly for 20 min and then heat up to 25 ° C, while reducing the stirring speed and stirring at a constant speed Reaction 7h. After the reaction, the product was filtered and washed thoroughly with methanol, distilled water and acetone in order to remove various impurities. Finally, the NG absorption peak at 283nm was detected in the washing solution with a UV photometer. After washing, the product was vacuum-dried to constant weight to obtain a rod-shaped molecularly imprinted cyclodextrin polymer.

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Abstract

The invention relates to a method for preparing a rod-like imprinted polymer capable of efficiently separating naringin in a water phase. The rod-like imprinted polymer which is an adsorption material having specific recognition capability for naringin organic molecular medicaments with =O and -OH groups can be prepared by an emulsion polymerization method, with the naringin, hesperidin, the naringin or dihydrochalcone as an imprinting molecules, cyclodextrin as a functive and hexamethylene diisocyanate as a cross-linking agent. The prepared rod-like imprinted cyclodextrin polymer has larger specific area and pore volume, benefits the contact of a substrate with a combined locus and improves the capacity. The rod-like molecular imprinted polymer (RMIP) has high affinity and selectivity to the naringin (NG). When the concentration of the NG is 0.02mg/ml, the imprinted molecule alpha reaches 1.53.

Description

technical field [0001] The invention relates to a method for preparing a rod-shaped polymer imprinted polymer for efficiently separating naringin in an aqueous phase. Background technique [0002] Naringin (NG for short) is a dihydroflavonoid compound, an active ingredient of various Chinese patent medicines, which has antioxidant properties (inhibits oxidase activity), anti-inflammatory and analgesic properties, anti-virus, antibacterial and anti-inflammatory properties. Aldose reductase and other biological activities and pharmacological effects. Flavonoids have dual functions of anti-oxidation and promotion of oxidation. And naringin is one of the most powerful substances to promote the oxidation of flavonoids, and it has an inductive and toxic effect on human genes. Therefore, the preparation of naringin-imprinted polymers is of great significance for the separation and extraction of naringin and the quality control of drugs. [0003] Cyclodextrin (CD) molecules have ...

Claims

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Application Information

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IPC IPC(8): C08J9/26C08J3/24C08B37/16C08L5/16B01J20/24B01J20/28B01J20/30
Inventor 陈震马秀玲陈日耀郑曦陈晓
Owner FUJIAN NORMAL UNIV
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