32 results about "Pyrilamine" patented technology

The invention relates to the technical field of herbicides and in particular discloses pyrilamine compounds with herbicidal activity and application thereof. The pyrilamine compounds with the herbicidal activity are the compounds represented by a general formula. In the specification, six compounds are particularly disclosed. The test result shows that the compounds represented by the general formula have good herbicidal activity, especially for gramineous weeds; and through using the compounds, crab grass, barnyard grass, Chinese pennisetum and the like suffer from albefaction so that the roots can not normally grow to be died. Thus, the compounds represented by the general formula are expected to serve as the herbicides in the fields of agriculture and others.

The invention provides a tomato gray mold antagonistic strain B-04-glu which is characterized by comprising four steps for the preparation: firstly, a strain of Bacillus cereus for high-efficient antagonistic gray mold is filtered from a soil sample infected by gray mold, and is named as B-04; secondly, bacteria solution which contains the B-04 bacteria is cultured; thirdly, ultrapure water, 1mM Hepes and electric shock buffer solution are used for washing in turn; fourthly, beta-1, 3-dextranase genes are transformed into the B-04 bacteria through electric shock method, and then the antagonistic strain B-04-glu is obtained. The antagonistic strain B-04-glu belongs to biological prevention and cure and does not contain compositions such as pyrilamine, pyrrole, acylamide and so on of chemical pesticide, thereby the antagonistic strain B-04-glu has the advantages of innocuity, no environmental pollution, difficult production of drug resistance, no residue, easy production, long effective period, strong curing ability, good application effect, safety on non-targeted organisms and so on and has wide application prospect.

The invention relates to a method for synthesizing N-(5-nitryl-2-methyl pyridyl-3-)-4-(3-pyridyl)-2-pyrilamine and an intermediate thereof. The method comprises the following steps: adding a compound IV and a compound V with the molar ratio of 1:(1-2) into a reactor; adding an organic solvent, wherein the volume weight ratio of the organic solvent to the compound IV is 5 to 10; stirring and dissolving; cooling to -20 to 0 DEG C; maintaining the temperature range and adding sodium hydride in batches, wherein the molar ratio of the sodium hydride to the compound IV is (2-6):1; and after adding the sodium hydride, maintaining the temperature to be 20 to 50 DEG C until the reaction is complete and a compound I is obtained.

The invention relates to application of a pyrilamine compound as a cycle protein dependency kinase 4 / 6 inhibitor. The compound is of a structure shown as formula (I), preferably, wherein R1 and R2 are respectively hydrogen, hydroxyl or alkyl, and X is halogen. More preferably, R1 is hydrogen or hydroxyl, R2 is alkyl, X is fluorine, chlorine or bromine; and particularly preferably, R1 is hydrogen, R2 is methyl, ethyl, propyl, isopropyl, normal-butyl, isobutyl or tertiary butyl, and X is fluorine.

The invention relates to application of pyrilamine compounds to the preparation of an acetylcholinesterase inhibitor. The pyrilamine compounds have a structure of a general formula I, wherein in the general formula I, S1 is selected from O, S, -CH2- and -NH-; S2 is selected from O, S, -N(CH3)-, -NH- and -(CH2)n-, and n is an integral number of 1 to 6; Q1 is selected from hydrogen, halogens, straight chain or branched chain alkyl, cycloalkyl, trihaloalkyl and alkoxy; Q2 and Q3 are selected from the hydrogen, the halogens, the straight chain or branched chain alkyl, the cycloalkyl, the trihaloalkyl, the alkoxy, aryl, heteroaryl, -(CO)R1 and -S(O2)R2 independently and respectively; R1 and R2 are selected from straight chain or branched chain alkyl having 1 to 4 carbon atoms and amino independently and respectively; and X1 and X2 are respectively selected from H, the straight chain or branched chain alkyl having 1 to 4 carbon atoms and haloalkyl having 1 to 4 carbon atoms independently.

The invention provides a carboxyl amide compound and its nontoxic salt, obtained by reaction of two compounds at 0-40 deg.C, where one compound contains 5-methyl pyrazine-2-radical, 5-methyl urea pyrilamine-1-methylene, urea pyrilamine-4-radical, coumarin-3-radical, 5-bromofuran-2-radical, quinoxaline-6-radical, 3-hydroxyl quinoxaline-2-radical, (thiophene -2-) or (indole-3-) or (imidazole-4-) ethylene, benzotriazole-5- radical, benzoimidazole-5-radical, (benzoimidazole-2-)ethyl, (2-amino thiazole-5-) or (2, 5-dioxyimidazoline-4-) methylene, or (benzo dioxypentane-5-) ethylene; and the other compound contains C1-8 alkyl, C1-8 oxyalkyl, aryl, or heteroatomic radical. It can be used to prepare disinfectant.

The invention provides a deuterated benzimidazole-pyrilamine derivative which is a compound shown in formula (I) shown in the specification or a pharmaceutically acceptable salt, a monocrystal substance or a polymorphic substance of the compound as well as an application of the derivative to preparation of drugs for treating cancer, and further provides pharmaceutical composition containing the compound. R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15 and R16 refer to hydrogen or deuterium independently, and at least one deuterium is contained in total. The deuterated benzimidazole-pyrilamine derivative mesylate prolongs half-life periods of the drugs, prolongs the retention time of the drugs in human bodies and increases concentration of the drugs in blood, so that the better curative effect can be realized.