Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Synthetic method for pharmaceutical intermediate namely 3-chloro-2-ethyl-4-pyrilamine

A synthesis method and pyrimidine amine technology are applied in the field of synthesis of pharmaceutical intermediates 3-chloro-2-ethyl-4-pyrimidine amine, can solve problems such as the synthesis method of unreported compounds, and achieve simple synthesis method and safe operation. Effect

Inactive Publication Date: 2017-03-22
WUXI QIANHAO BIOPHARMA
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The synthesis method of 3-chloro-2-ethyl-4-pyrimidinamine is the starting material for the synthesis of many drugs, especially the important intermediate of many pyrimidinamine compounds. There is no report on the synthesis method of this compound in China at present.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0008] The synthetic method of pharmaceutical intermediate 3-chloro-2-ethyl-4-pyrimidinamine of the present invention is specifically as follows:

[0009] Using pyrimidineamine as raw material, under the action of solvent acetone and 1.5 atmospheric pressure, at a temperature of 120°C-170°C, it undergoes methylation and chlorine replacement reactions respectively to generate 3-chloro-2-ethyl-4-pyrimidinamine synthetic method. The purity of this crude product can meet the general reaction requirements and can be directly put into the reaction.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a synthetic method for a pharmaceutical intermediate namely 3-chloro-2-ethyl-4-pyrilamine. The synthetic method synthesizes 3-chloro-2-ethyl-4-pyrilamine with pyrilamine as a raw material successively through methylation and chlorine replacement reactions under the actions of an acetone solvent and 1.5 atmospheres at a temperature of 120 DEG C to 170 DEG C. The synthetic method for the pharmaceutical intermediate namely 3-chloro-2-ethyl-4-pyrilamine provided by the invention has the advantages of simplicity, high efficiency, safe operation, and significant practicality in concrete production.

Description

technical field [0001] The invention relates to a method for synthesizing a pharmaceutical intermediate 3-chloro-2-ethyl-4-pyrimidinamine. Background technique [0002] The synthesis method of 3-chloro-2-ethyl-4-pyrimidinamine is the starting material for the synthesis of many medicines, especially the important intermediate of many pyrimidinamine compounds. There is no report on the synthesis method of this compound in China at present. Contents of the invention [0003] The object of the present invention is to overcome above-mentioned deficiency, provide a kind of simple, efficient, safe operation pharmaceutical intermediate 3-chloro-2-ethyl-4-pyrimidinamine synthetic method. [0004] The purpose of the present invention is achieved like this: [0005] A method for synthesizing pharmaceutical intermediate 3-chloro-2-ethyl-4-pyrimidinamine, using pyrimidinamine as a raw material, under the action of solvent acetone and 1.5 atmospheric pressure, at a temperature of 120°C...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07D239/42
CPCC07D239/42
Inventor 彭海燕
Owner WUXI QIANHAO BIOPHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com