Synthetic method for pharmaceutical intermediate namely 3-chloro-2-ethyl-4-pyrilamine

A synthesis method and pyrimidine amine technology are applied in the field of synthesis of pharmaceutical intermediates 3-chloro-2-ethyl-4-pyrimidine amine, can solve problems such as the synthesis method of unreported compounds, and achieve simple synthesis method and safe operation. Effect

Inactive Publication Date: 2017-03-22
WUXI QIANHAO BIOPHARMA
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Problems solved by technology

[0002] The synthesis method of 3-chloro-2-ethyl-4-pyrimidinamine is the starting material for the synthesis of many drugs, especially the important intermediate of many pyrimidinamine compounds. There is no report on the synthesis method of this compound in China at present.

Method used

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Embodiment Construction

[0008] The synthetic method of pharmaceutical intermediate 3-chloro-2-ethyl-4-pyrimidinamine of the present invention is specifically as follows:

[0009] Using pyrimidineamine as raw material, under the action of solvent acetone and 1.5 atmospheric pressure, at a temperature of 120°C-170°C, it undergoes methylation and chlorine replacement reactions respectively to generate 3-chloro-2-ethyl-4-pyrimidinamine synthetic method. The purity of this crude product can meet the general reaction requirements and can be directly put into the reaction.

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Abstract

The invention relates to a synthetic method for a pharmaceutical intermediate namely 3-chloro-2-ethyl-4-pyrilamine. The synthetic method synthesizes 3-chloro-2-ethyl-4-pyrilamine with pyrilamine as a raw material successively through methylation and chlorine replacement reactions under the actions of an acetone solvent and 1.5 atmospheres at a temperature of 120 DEG C to 170 DEG C. The synthetic method for the pharmaceutical intermediate namely 3-chloro-2-ethyl-4-pyrilamine provided by the invention has the advantages of simplicity, high efficiency, safe operation, and significant practicality in concrete production.

Description

technical field [0001] The invention relates to a method for synthesizing a pharmaceutical intermediate 3-chloro-2-ethyl-4-pyrimidinamine. Background technique [0002] The synthesis method of 3-chloro-2-ethyl-4-pyrimidinamine is the starting material for the synthesis of many medicines, especially the important intermediate of many pyrimidinamine compounds. There is no report on the synthesis method of this compound in China at present. Contents of the invention [0003] The object of the present invention is to overcome above-mentioned deficiency, provide a kind of simple, efficient, safe operation pharmaceutical intermediate 3-chloro-2-ethyl-4-pyrimidinamine synthetic method. [0004] The purpose of the present invention is achieved like this: [0005] A method for synthesizing pharmaceutical intermediate 3-chloro-2-ethyl-4-pyrimidinamine, using pyrimidinamine as a raw material, under the action of solvent acetone and 1.5 atmospheric pressure, at a temperature of 120°C...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D239/42
CPCC07D239/42
Inventor 彭海燕
Owner WUXI QIANHAO BIOPHARMA
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