Synthetic method for pharmaceutical intermediate namely 3-chloro-2-ethyl-4-pyrilamine

Abstract

The invention relates to a synthetic method for a pharmaceutical intermediate namely 3-chloro-2-ethyl-4-pyrilamine. The synthetic method synthesizes 3-chloro-2-ethyl-4-pyrilamine with pyrilamine as a raw material successively through methylation and chlorine replacement reactions under the actions of an acetone solvent and 1.5 atmospheres at a temperature of 120 DEG C to 170 DEG C. The synthetic method for the pharmaceutical intermediate namely 3-chloro-2-ethyl-4-pyrilamine provided by the invention has the advantages of simplicity, high efficiency, safe operation, and significant practicality in concrete production.

Description

technical field [0001] The invention relates to a method for synthesizing a pharmaceutical intermediate 3-chloro-2-ethyl-4-pyrimidinamine. Background technique [0002] The synthesis method of 3-chloro-2-ethyl-4-pyrimidinamine is the starting material for the synthesis of many medicines, especially the important intermediate of many pyrimidinamine compounds. There is no report on the synthesis method of this compound in China at present. Contents of the invention [0003] The object of the present invention is to overcome above-mentioned deficiency, provide a kind of simple, efficient, safe operation pharmaceutical intermediate 3-chloro-2-ethyl-4-pyrimidinamine synthetic method. [0004] The purpose of the present invention is achieved like this: [0005] A method for synthesizing pharmaceutical intermediate 3-chloro-2-ethyl-4-pyrimidinamine, using pyrimidinamine as a raw material, under the action of solvent acetone and 1.5 atmospheric pressure, at a temperature of 120°C...

AI Technical Summary

Problems solved by technology

[0002] The synthesis method of 3-chloro-2-ethyl-4-pyrimidinamine is the starting material for the synthesis of many drugs, especially the important intermediate of many pyrimidinamine compounds. There is no report on the synthesis method of this compound in China at present.