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Synthetic method of medicinal raw material 5-fluorine-2-methyl-4-pyrilamine

A synthesis method and pyrimidine amine technology are applied in the field of synthesis of medical raw material 5-fluoro-2-methyl-4-pyrimidine amine, can solve problems such as unreported compound synthesis methods, and achieve a simple synthesis method and safe operation. Effect

Inactive Publication Date: 2017-03-15
WUXI QIANHAO BIOPHARMA
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Problems solved by technology

[0002] The synthesis method of 5-fluoro-2-methyl-4-pyrimidinamine is the starting material for the synthesis of many drugs, especially the important intermediates of many pyrimidinamine compounds. At present, there is no report on the synthesis method of this compound in China

Method used

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Embodiment Construction

[0008] The synthetic method of medical raw material 5-fluoro-2-methyl-4-pyrimidinamine of the present invention is specifically as follows:

[0009] Using pyrimidine as raw material, under the action of solvent ethanol, at a temperature of 100°C-160°C, successively through fluorination, methylation and amination to generate 5-fluoro-2-methyl-4-pyrimidinamine synthesis method . The purity of this crude product can meet the general reaction requirements and can be directly put into the reaction.

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Abstract

The invention relates to a synthetic method of a medicinal raw material 5-fluorine-2-methyl-4-pyrilamine. According to the synthetic method, pyrimidine is adopted as a raw material, and under the action of a solution ethyl alcohol, 5-fluorine-2-methyl-4-pyrilamine is generated through fluorination, methylation and amination respectively in sequence at the temperature of 100-160 DEG C. The synthetic method of the medicinal raw material 5-fluorine-2-methyl-4-pyrilamine is simple and efficient, safe to operate and very practical in specific production.

Description

technical field [0001] The invention relates to a synthesis method of medical raw material 5-fluoro-2-methyl-4-pyrimidinamine. Background technique [0002] The synthesis method of 5-fluoro-2-methyl-4-pyrimidinamine is the starting material for the synthesis of many drugs, especially the important intermediate of many pyrimidinamine compounds. There is no report on the synthesis method of this compound in China at present. Contents of the invention [0003] The purpose of the present invention is to overcome the above-mentioned shortcomings, and provide a simple, efficient and safe synthetic method for medical raw material 5-fluoro-2-methyl-4-pyrimidinamine. [0004] The purpose of the present invention is achieved like this: [0005] A method for synthesizing medical raw material 5-fluoro-2-methyl-4-pyrimidinamine, using pyrimidine as raw material, under the action of solvent ethanol, successively through fluorination and methylation at a temperature of 100°C-160°C and ...

Claims

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Application Information

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IPC IPC(8): C07D239/42
CPCC07D239/42
Inventor 彭海燕
Owner WUXI QIANHAO BIOPHARMA
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