Synthetic method of medicinal raw material 5-fluorine-2-methyl-4-pyrilamine

A synthesis method and pyrimidine amine technology are applied in the field of synthesis of medical raw material 5-fluoro-2-methyl-4-pyrimidine amine, can solve problems such as unreported compound synthesis methods, and achieve a simple synthesis method and safe operation. Effect

Inactive Publication Date: 2017-03-15
WUXI QIANHAO BIOPHARMA
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The synthesis method of 5-fluoro-2-methyl-4-pyrimidinamine is the starting material for the synthesis of many drugs, especially the

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0008] The synthetic method of medical raw material 5-fluoro-2-methyl-4-pyrimidinamine of the present invention is specifically as follows:

[0009] Using pyrimidine as raw material, under the action of solvent ethanol, at a temperature of 100°C-160°C, successively through fluorination, methylation and amination to generate 5-fluoro-2-methyl-4-pyrimidinamine synthesis method . The purity of this crude product can meet the general reaction requirements and can be directly put into the reaction.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to a synthetic method of a medicinal raw material 5-fluorine-2-methyl-4-pyrilamine. According to the synthetic method, pyrimidine is adopted as a raw material, and under the action of a solution ethyl alcohol, 5-fluorine-2-methyl-4-pyrilamine is generated through fluorination, methylation and amination respectively in sequence at the temperature of 100-160 DEG C. The synthetic method of the medicinal raw material 5-fluorine-2-methyl-4-pyrilamine is simple and efficient, safe to operate and very practical in specific production.

Description

technical field [0001] The invention relates to a synthesis method of medical raw material 5-fluoro-2-methyl-4-pyrimidinamine. Background technique [0002] The synthesis method of 5-fluoro-2-methyl-4-pyrimidinamine is the starting material for the synthesis of many drugs, especially the important intermediate of many pyrimidinamine compounds. There is no report on the synthesis method of this compound in China at present. Contents of the invention [0003] The purpose of the present invention is to overcome the above-mentioned shortcomings, and provide a simple, efficient and safe synthetic method for medical raw material 5-fluoro-2-methyl-4-pyrimidinamine. [0004] The purpose of the present invention is achieved like this: [0005] A method for synthesizing medical raw material 5-fluoro-2-methyl-4-pyrimidinamine, using pyrimidine as raw material, under the action of solvent ethanol, successively through fluorination and methylation at a temperature of 100°C-160°C and ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): C07D239/42
CPCC07D239/42
Inventor 彭海燕
Owner WUXI QIANHAO BIOPHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap