Synthetic method of medicinal raw material 5-fluorine-2-methyl-4-pyrilamine

Abstract

The invention relates to a synthetic method of a medicinal raw material 5-fluorine-2-methyl-4-pyrilamine. According to the synthetic method, pyrimidine is adopted as a raw material, and under the action of a solution ethyl alcohol, 5-fluorine-2-methyl-4-pyrilamine is generated through fluorination, methylation and amination respectively in sequence at the temperature of 100-160 DEG C. The synthetic method of the medicinal raw material 5-fluorine-2-methyl-4-pyrilamine is simple and efficient, safe to operate and very practical in specific production.

Description

technical field [0001] The invention relates to a synthesis method of medical raw material 5-fluoro-2-methyl-4-pyrimidinamine. Background technique [0002] The synthesis method of 5-fluoro-2-methyl-4-pyrimidinamine is the starting material for the synthesis of many drugs, especially the important intermediate of many pyrimidinamine compounds. There is no report on the synthesis method of this compound in China at present. Contents of the invention [0003] The purpose of the present invention is to overcome the above-mentioned shortcomings, and provide a simple, efficient and safe synthetic method for medical raw material 5-fluoro-2-methyl-4-pyrimidinamine. [0004] The purpose of the present invention is achieved like this: [0005] A method for synthesizing medical raw material 5-fluoro-2-methyl-4-pyrimidinamine, using pyrimidine as raw material, under the action of solvent ethanol, successively through fluorination and methylation at a temperature of 100°C-160°C and ...

AI Technical Summary

Problems solved by technology

[0002] The synthesis method of 5-fluoro-2-methyl-4-pyrimidinamine is the starting material for the synthesis of many drugs, especially the important intermediates of many pyrimidinamine compounds. At present, there is no report on the synthesis method of this compound in China