Preparation method of mono-methoxyl pyrilamine

A technology of monomethoxypyrimidinamine and methoxypyrimidinamine, which is applied in the field of pesticide synthesis, can solve the problems of high environmental harm, complicated operation and high energy consumption, and achieves the effects of reducing health harm, good operating environment and simple operation.

Inactive Publication Date: 2016-02-03
ANHUI HONGDE CHEM THECHNOLOGY CO LTD
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  • Abstract
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Problems solved by technology

[0010] The purpose of the present invention is to provide a method for preparing monomethoxypyrimidinamine, which better solves the technical problems of complex operation, high energy consumption, low yield, and large environmental hazards in the existing synthetic methods.

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  • Preparation method of mono-methoxyl pyrilamine
  • Preparation method of mono-methoxyl pyrilamine
  • Preparation method of mono-methoxyl pyrilamine

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Embodiment Construction

[0032] In order to facilitate understanding of the present invention, the present invention enumerates the following examples. Those skilled in the art should understand that the examples are only used to help understand the present invention, and should not be regarded as specific limitations on the present invention.

[0033] Unless otherwise specified, various raw materials of the present invention can be obtained commercially; or prepared according to conventional methods in the art. Unless otherwise defined or stated, all professional and scientific terms used herein have the same meaning as is familiar to those skilled in the art. In addition, any methods and materials similar or equivalent to those described can be applied to the method of the present invention.

[0034] A method for preparing monomethoxypyrimidine amine, using dichloropyrimidine and sodium methylate as raw materials to carry out nucleophilic substitution reaction, the specific operation process is:

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Abstract

The invention discloses a preparation method of mono-methoxyl pyrilamine. According to the method, dichloropyrimidine and sodium methoxide are used as raw materials for performing nucleophilic substitution reaction. The method comprises the steps including reaction decoloration, thermal filtration, crystallization, centrifugation and drying. The reaction and the decoloration are completed in one step, so that the synthesis steps are greatly reduced; the operation work procedure is simplified. Crude product refining is not needed. Compared with the existing preparation method, the preparation method has the obvious advantages in the aspects of reducing the production cost, reducing the environment harm, maintaining the human body health and the like.

Description

technical field [0001] The invention belongs to the technical field of pesticide synthesis, and in particular relates to a preparation method of monomethoxypyrimidinamine. Background technique [0002] Amethoxypyrimidine, chemical name: 2-amino-4-chloro-6-methoxypyrimidine, English name is 2-Amino-4-chloro-6-methoxypyrimidine; CAS number: 5734-64-5; Its structural formula is as follows: [0003] [0004] Amethoxypyrimidinamine is a pesticide intermediate, which can be used to synthesize sulfonylurea pesticides, such as bensulfuron-methyl, nicosulfuron-methyl, cyprosulfuron-methyl, ethoxysulfuron-methyl, rimsulfuron-methyl, acyrimuron-methyl Sulfuron etc. [0005] At present, the synthetic route of monomethoxypyrimidinamine is as follows: [0006] [0007] The main production operation process in the above-mentioned synthetic route comprises: [0008] 1), put methanol and dichloropyrimidine into the reaction kettle, after heating up to reflux, add sodium methoxide d...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D239/42
CPCC07D239/42
Inventor 卜孝凡
Owner ANHUI HONGDE CHEM THECHNOLOGY CO LTD
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