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Application of composition containing heterocyclic compound in preparation of drug for treating leukemia

A compound, leukemia technology, applied in the field of medicine, can solve the problem that the activity needs to be further improved

Inactive Publication Date: 2020-06-26
黄泳华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The phenylcarbamoylthiazole compound II with the structure shown below is also a CML drug approved by the FDA. Research by Cai Zhiping et al. Ⅱ The IC50 of K562 cells is about 244.00μg / mL, and its activity needs to be further improved

Method used

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  • Application of composition containing heterocyclic compound in preparation of drug for treating leukemia
  • Application of composition containing heterocyclic compound in preparation of drug for treating leukemia
  • Application of composition containing heterocyclic compound in preparation of drug for treating leukemia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0079] Embodiment 1 Oral solid preparation containing pyridyl pyrimidine amine compound and its preparation method

[0080] prescription

[0081]

[0082]

[0083]

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[0086]

[0087]

[0088] Preparation

[0089] Take the prescribed amount of MIX (X-Y) and auxiliary materials, and pass through a 100-mesh sieve. Get MIX (X-Y), lactose, microcrystalline cellulose, crospovidone and starch and fully mix; get the prescription amount of hypromellose, and prepare a solution with a concentration of 10% based on hypromellose, Use lactic acid to adjust the pH to 3.0-4.0, add it to the above-mentioned mixture to make a soft material, granulate with a 16-mesh sieve, and dry at 80°C for 3-4 hours. Use a 16-mesh sieve to sieve the granules, add the prescribed amount of micropowder silica gel and magnesium stearate, mix well, fill the capsules, and each capsule weighs about 500mg;

[0090] Take the prescribed amount of MIX (X-Y) and auxiliary mater...

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Abstract

The invention relates to an application of composition containing a heterocyclic compound in preparation of a drug for treating leukemia. On one hand, the invention provides an application of composition containing pyridyl pyrilamine compounds in preparation of the drug for treating the leukemia; on the other hand, the invention provides an application of composition containing phenyl aminoformylthiazole compounds in preparation of the drug for treating the leukemia; and the invention provides an application of quinoline compounds in preparation of the drug for treating the leukemia.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the use of a composition containing a heterocyclic compound in the preparation of a medicine for treating leukemia. Background technique [0002] The pyridyl pyrimidine amine compound I with the structure shown below is a commonly used clinical drug for treating chronic myeloid leukemia (CML), but its medicinal dose is relatively high (100mg-400mg), indicating that its anti-inflammatory effect needs to be further improved. . For example, the research results of Zhong Jihua et al. (Diagnostics Theory and Practice, 2010, 9(05): 469-472.), imatinib acts on the IC of K562, K562 / pc and K562 / CYP3A5 cells 50 The values ​​were (55.313±0.248), (57.043±0.486) and (72.910±0.776) μg / mL, respectively. [0003] [0004] The phenylcarbamoylthiazole compound II with the structure shown below is also a CML drug approved by the FDA. Research by Cai Zhiping et al. The IC50 of II ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/506A61K31/426A61K31/529A61K31/496A61K31/47A61P35/02
CPCA61K31/426A61K31/47A61K31/496A61K31/506A61K31/529A61P35/02A61K2300/00
Inventor 向飞吴洁
Owner 黄泳华
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