Method for improving blood compatibility of material

A blood compatibility and solution technology, which is applied to the device and coating of the surface coating liquid, can solve the problems of harsh conditions in the synthesis process, limited application range, difficulty in storage, etc., and achieves a simple preparation method and wide application Foreground, Effects of Moderate Conditions

Inactive Publication Date: 2014-06-25
XIAN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] However, the crosslinkable group of the polymer is easy to hydrolyze and crosslink during the synthesis process, which makes the conditions of the synthesis process too harsh and difficult to preserve, which limits its application range

Method used

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  • Method for improving blood compatibility of material
  • Method for improving blood compatibility of material

Examples

Experimental program
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Effect test

Embodiment 1

[0024] Step 1. Weigh 12mmol of 2-methacryloyloxyethyl phosphorylcholine (MPC) and 8mmol of 2-aminoethyl methacrylate hydrochloride, dissolve them in distilled water and mix them evenly to obtain a mixed solution of monomers. 0.1mmol potassium persulfate is dissolved in distilled water to obtain initiator solution, and in N 2 Protection, under the condition of stirring at 70°C, add the mixed solution of monomers into the three-necked flask, preheat for 30 minutes, add the initiator solution to continue the reaction for 12 hours, after the reaction is completed, concentrate the reaction solution, and use a dialyzer with a molecular weight cut-off of 6000-8000D bag dialysis; finally, freeze-dry the dialyzed sample at -50°C to obtain amino group-containing phosphorylcholine polymer;

[0025] Step 2, the phosphorylcholine polymer containing amino group described in step 1 and dopamine are dissolved in methanol together according to the molar ratio of amino group and dopamine is 0.8...

Embodiment 2

[0031] The amino group-containing phosphorylcholine polymer prepared in Example 1 and dopamine are dissolved in ethanol together according to the molar ratio of amino group and dopamine of 1.8:1, and stirred evenly to obtain a coating solution, and then the pH value of the coating solution is adjusted to 8.5; the chitosan material to be modified is placed in the coating solution after adjusting the pH value and dip-coated for 1h, taken out and washed with distilled water, and the surface of the chitosan material to be modified is obtained. Structural coating.

[0032] Compared with the chitosan material without coating treatment, the advancing angle and the receding angle of the chitosan treated by coating are all reduced, and phosphorylcholine appears. N and P characteristic absorption peaks on the group. This is because the phosphorylcholine polymer containing amino groups is fixed on the surface of chitosan through the reaction of amino groups and dopamine, and obtains a s...

Embodiment 3

[0034] Step 1. Weigh 6mmol of acryloyloxyethylphosphorylcholine and 14mmol of 2-aminoethyl acrylate hydrochloride, dissolve and mix them uniformly in distilled water to obtain a mixed solution of monomers, and dissolve 0.1mmol of potassium persulfate in distilled water to obtain Initiator solution, in N 2 Protection, under the condition of stirring at 70°C, add the mixed solution of monomers into the three-necked flask, preheat for 30 minutes, add the initiator solution to continue the reaction for 12 hours, after the reaction is completed, concentrate the reaction solution, and use a dialyzer with a molecular weight cut-off of 6000-8000D bag dialysis; finally, freeze-dry the dialyzed sample at -50°C to obtain amino group-containing phosphorylcholine polymer;

[0035] Step 2, the phosphorylcholine polymer containing amino group described in step 1 and dopamine are dissolved in methanol together according to the molar ratio of amino group and dopamine is 1:1, stir evenly to obt...

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Abstract

The invention discloses a method for improving blood compatibility of a material. The method includes the following steps: 1, synthesizing a polymer containing an amino group; 2, dissolving the polymer containing the amino group in a polar solvent together with dopamine, and stirring uniformly to obtain a costing solution; and 3, coating the costing solution on the surface of a material to be modified to obtain a coating with a simulated cell outer layer membrane structure on the surface of the material to be modified. According to the method, the polymer containing the amino group is coated on the surface of the material to be modified after being mixed with the dopamine, the reaction of the amino group and the dopamine in the coating is controlled by the pH value of the coating solution, so that the density of the coating is increased to fix a phosphorylcholine group on the surface of the material, obtain the surface having the simulated cell outer layer membrane structure, to greatly improve the hydrophilicity of the material, so as to improve the blood compatibility of the material.

Description

technical field [0001] The invention belongs to the technical fields of material surface science and biomedical polymer materials, and in particular relates to a method for improving the blood compatibility of materials. Background technique [0002] Chitosan has the advantages of degradability, antibacterial, non-toxic, non-irritating, and pH responsiveness (Carbohydrate Polymers 2010, 79:724-730), and has been widely used in biomedicine and other fields. More and more studies have shown that chitosan and its derivatives can be used for blood purification. The amino groups on chitosan molecules help to adsorb various toxins in blood, and can be used as hemoperfusion materials (Chemical Journal of Chinese Universities, 2002, 23: 75-77; Journal of Microencapsulation 1993, 10: 475-486). Chitosan membrane has high dialysis rate, selectivity and strength, and can be used as hemodialysis material (Journal of Applied Polymer Science 1992, 46:255-261; 263-269). Although chitosan ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J7/04C08F220/36C08F220/34C08F220/38C09D133/14C09D7/12B05D7/24
Inventor 宫铭李主峰傅嘉伦汪晓芹褚佳
Owner XIAN UNIV OF SCI & TECH
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