The invention discloses a preparation method of environment-friendly suede leather, and belongs to the field of leather production. The method comprises the treatment processes of soaking in water, liming, deliming, pickling, tanning, shaving, retanning, neutralizing, dyeing and fat liquoring, and drying and finishing. Epoxy silicone oil, isocyanate crosslinked silane and polyurethane crosslinkedsilica gel are added in the tanning process, and drum tanning is performed; and a chromium retanning agent, epoxy silicone oil, fat liquoring silicone oil and retanning silica gel are added in the retanning treatment process, and mixing retanning is carried out. The epoxy silicone oil, isocyanate crosslinked silane and polyurethane crosslinked silica gel are added in tanning and retanning processes, so that the compatibility of all process additives can be effectively improved, the foaming feeling and the flexibility of leather are enhanced, and the foaming feeling, the filling property, the flexibility, the velvet feeling and the folding resistance of the leather are effectively improved; and the leather has good compatibility, and can directly enters neutralizing, dyeing and fat liquoring processes without water washing, so sewage discharge is reduced, energy conservation and emission reduction are achieved, the process time is shortened by 20%, and the water consumption is reduced by 50-60%.