Functional polymer containing phosphorylcholine and PEG and method for forming anti-pollution coating with functional polymer

A polymer, nitrophenoxy formyl methacrylate technology, applied in coatings, biocide-containing paints, antifouling/underwater coatings, etc., to achieve simple construction methods and biocompatibility Broad, good flexibility and hydrophilic effect

Active Publication Date: 2015-05-13
NORTHWEST UNIV(CN)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in polymers, when the content of catechol groups is less than 15%, it is difficult to directly adhere to the surface of hydrophobic polypropylene and polytetrafluoroethylene.

Method used

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  • Functional polymer containing phosphorylcholine and PEG and method for forming anti-pollution coating with functional polymer
  • Functional polymer containing phosphorylcholine and PEG and method for forming anti-pollution coating with functional polymer
  • Functional polymer containing phosphorylcholine and PEG and method for forming anti-pollution coating with functional polymer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Embodiment 1: Preparation of active ester polymerizable monomer NPCEMA

[0044]

[0045] Weigh 4.009 g of HEMA and 3.110 g of TEA in a 100 mL three-necked bottle, add 20 mL of chloroform to dissolve them, and stir mechanically. Weigh 7.434 g of NPC in a round-bottomed flask, dissolve it with 35 mL of chloroform, and add it dropwise to the above-mentioned three-necked flask to react for 4 h. Precipitate with anhydrous ether to remove triethylamine hydrochloride, recover the supernatant and concentrate, wash three times with pH 3~4 phosphate buffer solution, and dry calcium chloride powder. The solvent was removed to obtain the product NPCEMA as a white solid, 7.287 g. CDCl 3 in solvent 1 H-NMR confirmed the structure of the product with a purity of 96%.

Embodiment 2

[0046] Embodiment 2: Contain the preparation of active ester functional polymer PMENG

[0047] The reaction process is as figure 1shown. Add 10 mL of absolute ethanol into a 100 mL three-necked flask, pass through nitrogen, stir with a magnetic force and gradually raise the temperature to 70 °C. Weigh 0.140 g of NPCEMA, 2.726 g of PEGA and 0.805 g of MPC in turn, and add 34 mL of absolute ethanol to dissolve them. Weigh 0.037 g AIBN and add it to the monomer mixture. Use the dropping funnel to drop the mixed solution of the monomers, and the dropwise addition is completed in about 2 hours. Change to a closed system and allow it to continue to react for 24 h. After the reaction was stopped, part of the reaction solution was taken out and put into a dialysis bag with a molecular weight cut off of 7000, and dialyzed in an acidic aqueous solution with a pH of 3~4. Freeze dried. D. 2 O solvent 1 H-NMR characterizes its structure, and it is composed of polymer PMENG with 12%...

Embodiment 3

[0048] Example 3: Grafting dopamine PMEDG, introducing a catechol group with adhesion function through the reaction of active ester and amino group

[0049] Continue to pass nitrogen in the three-necked flask of the previous step reaction, and gradually raise the temperature to 60°C in the oil bath. Weigh 0.145 g of dopamine into the above-mentioned three-neck flask, add 20 mL of ethanol, and adjust the pH of the reaction solution to about 7 with triethylamine, and react for about 12 h. Adjust the reaction solution to acidity, stop the nitrogen flow, transfer it to a dialysis bag with a molecular weight cut off of 7000, and dialyze it with an acidic aqueous solution with a pH of 3~4 for 3 days. Freeze dried. D. 2 O solvent use 1 H-NMR characterizes its structure. Such as figure 2 shown. The molar content of catechol groups, phosphorylcholine groups and polyethylene glycol chains were 8%, 64% and 28% copolymer PMEDG respectively.

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Abstract

The invention discloses a functional polymer containing phosphorylcholine and PEG and a method for forming a biological pollution resistant interface. The polymer is a functional polymer that contains multiple function groups on a side chain and has a controllable proportion; a PEG flexible chain with larger steric hindrance and outer cell membrane phosphorylcholine hydrophilic group interact to achieve good anti-pollution effect; the polymer contains less than 10% of catechol group, and can be strongly combined with surfaces of various polydopamine-mediated base materials to form a stable hydrophilic monomolecular coating, so that the functional modification of material surfaces is implemented. The method for forming coatings is simple; the coatings can exist on the surface of any base material, so that the ability of resisting adhesion and pollution of multiple biological ingredients of the material surface is improved.

Description

technical field [0001] The invention relates to a functional polymer containing phosphorylcholine and polyethylene glycol and a method for constructing an antifouling coating thereof, belonging to the technical field of surface modification. technical background [0002] With the rapid development of biotechnology, biomedical materials have become a hot spot in the current scientific research field. However, in the clinical application of existing biomedical materials and devices, problems such as infection, blood coagulation, and postoperative tissue hyperplasia exist to varying degrees. These biocompatibility problems have become key factors restricting the clinical application of biomedical materials. Currently, surface modification of materials is a very effective way to improve their biocompatibility. [0003] Generally speaking, the biocompatibility of materials can be improved by coating hydrophilic substances on the surface of the substrate to form a hydration layer...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F290/06C08F230/02C08F222/22C08F8/32C09D151/08C09D5/16B05D7/24B05D3/02
Inventor 权苗党媛宫永宽
Owner NORTHWEST UNIV(CN)
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