Imitation mussel attachment protein and cell membrane structure copolymer and preparation method and application thereof

A mussel adhesion protein and adhesion protein technology, applied in the fields of polymer chemistry and physics, surface science and biomedical materials, can solve the problem of unstable physical adsorption polymer coating, unsatisfactory modification effect, coating process Complicated problems, to achieve the effect of improved surface hydrophilicity and biocompatibility, good biocompatibility, and simple construction method
CN102887976AActive Publication Date: 2013-01-23NORTHWEST UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
NORTHWEST UNIV
Publication Date
2013-01-23

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Abstract

The invention discloses an imitation mussel attachment protein and cell membrane structure double-bionic copolymer shown by the structural formula (I), wherein m is an integer from 10 to 1,000, n is an integer from 0 to 500, and x is an integer from 5 to 500; in the m, n and x, the molar percentage of m is 30-90%, the molar percentage of n is 0-50%, and the molar percentage of x is 10-70%; R1, R2 and R3 are H or CH3; R4 is an alkyl with 4-18 carbon atoms; V is a catechol group with 2-300 carbon atoms in chain connection; W is a hydrophilic group with 2-8 carbon atoms in chain connection; and the hydrophilic group is a quaternary ammonium group, phosphorylcholine group, pyridinium, sulfonic acid group, phosphate group, carboxylic acid group or sulfuric acid group. According to the invention, the coating is in firm combination, the copolymer is almost suitable for an establishment method of a surface imitation cellulosa membrane structure of any material, and the surface hydrophilic performance and biocompatibility of artificial organ and related materials, medicine controlled-release systems, separation materials and other materials can be improved.
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Description

technical field

[0001] The invention relates to mussel adhesion protein and cell membrane structure double biomimetic copolymer and its preparation method, in particular to an adhesive type (meth)acrylic ester copolymer with imitation cell membrane structure, which belongs to polymer chemistry and physics, surface science and biomedicine field of materials technology. Background technique

[0002] Phosphorylcholine is a hydrophilic group of the outer membrane of biological cells. The modified material is coated with a hydrophilic-lipophilic amphiphilic polymer containing phosphorylcholine groups. When it contacts with water, its surface forms an imitation The cell membrane structure will be regarded as self by the cells, which can obtain excellent biocompatibility.

[0003] This kind of phosphorylcholine group-containing polymer coating can be attached to the surface of the modified material through physical adsorption or chemical bonding. However, the amphiphilic polymer ...

Claims

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