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Coated nanoliposomes of resveratrol and preparation method thereof

A nano-liposome and resveratrol technology, which is applied in liposome delivery, pharmaceutical formulations, medical preparations of non-active ingredients, etc., can solve problems such as low bioavailability, poor absorption, and light instability. Achieve the effects of reducing toxic and side effects, enhancing pharmacological effects, and enhancing stability

Inactive Publication Date: 2007-04-25
李万忠
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Problems solved by technology

[0005] The application of modern medical technology and methods shows that many active ingredients of traditional Chinese medicine, such as puerarin, quercetin, baicalin, etc., have serious absorption problems in the body, resulting in low bioavailability, unable to effectively exert their therapeutic effects, and limiting their use. Clinical application and related industrialization development
[0006] Although resveratrol is a promising drug for tumor prevention and treatment, it is poorly absorbed in the body due to its poor solubility in water, instability to light, and limitations of its own physical and chemical properties. The bioavailability is not high, and the clinical effect is not ideal

Method used

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  • Coated nanoliposomes of resveratrol and preparation method thereof

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Embodiment 1

[0049] Example 1: Resveratrol-coated nano-liposomes, the liposomes are composed of the following components: resveratrol, lecithin, cholesterol, chitosan chloride, mannitol, and sorbitol.

[0050]The weight percentage of each composition of described liposome is:

[0051] Resveratrol 5%

[0052] Lecithin, Cholesterol 55%

[0053] Chitosan Chloride 0.5%

[0054] Mannitol, Sorbitol 39.5%.

[0055] The preparation method of resveratrol-coated nano liposome comprises the following steps:

[0056] a. Preparation of liposomes

[0057] (1) Accurately weigh and mix lecithin and cholesterol according to a molar ratio of 1:1, then dissolve the mixture in chloroform solution to obtain a lipid solution;

[0058] (2) Weigh resveratrol according to the proportion, dissolve it in ethanol, add the obtained resveratrol ethanol solution into the lipid solution, then transfer it to a 250mL eggplant-shaped bottle, and keep the temperature in a water bath at 37°C;

[0059] (3) Use a rotary e...

Embodiment 2

[0065] Embodiment 2: Resveratrol-coated nano-liposomes, the liposomes are composed of the following components: resveratrol, soybean lecithin, cholesterol, chitosan chloride, lactose, sucrose.

[0066] The weight percentage of each composition of described liposome is:

[0067] Resveratrol 9%

[0068] Soy Lecithin, Cholesterol 70%

[0069] Chitosan Chloride 0.8%

[0070] Lactose, sucrose 20.2%.

[0071] The preparation method of resveratrol-coated nano liposome comprises the following steps:

[0072] a. Preparation of liposomes

[0073] (1) Precisely weigh soybean lecithin and cholesterol according to a molar ratio of 3:1 and mix them, then weigh the mixture according to the ratio and dissolve it in chloroform solution to obtain a lipid solution;

[0074] (2) Weigh resveratrol according to the proportion, dissolve it in ethanol, add the obtained resveratrol ethanol solution into the lipid solution, then transfer it to a 250mL eggplant-shaped bottle, and keep the temperatu...

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Abstract

The invention discloses a dressed millimicron liposome of resveratrol, liposome comprises resveratrol, lecithin or soybean lecithin, cholesterin 50-85%, chloridized chitosan 0.5-1% and auxiliary materials 5-40%. The dressed liposome has the advantages of better adaptability for patients and simpler preparing process.

Description

technical field [0001] The invention relates to an antitumor drug, in particular to a resveratrol-coated nano liposome and a preparation method thereof. Background technique [0002] Tumor is a common and frequently-occurring disease, which poses a great threat to people's life and health. It is a research topic that has received more and more attention in the medical field. More than 7 million people die from cancer every year all over the world, and now there are about 37 million cancer patients. In my country, about 1.3 million people die of cancer every year, and the estimated incidence is between 1.8 million and 2 million. The overall incidence is constantly rising. In many large cities in China, malignant tumors have surpassed cardiovascular and cerebrovascular diseases, ranking first among all causes of death, and in the age group of 35 to 59, tumors have always been the number one killer. In the past, many severe infectious diseases that seriously threatened people...

Claims

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Application Information

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IPC IPC(8): A61K9/127A61K31/047A61K47/36A61P35/00
Inventor 李万忠
Owner 李万忠
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