Topical compositions comprising bimatoprost and methods for stimulating hair growth therewith

A bimatoprost, hair growth technology, applied in the directions of hair care, drug combination, medical formula, etc., can solve problems such as not being recognized as effective

Inactive Publication Date: 2016-01-20
ALLERGAN INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

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  • Topical compositions comprising bimatoprost and methods for stimulating hair growth therewith
  • Topical compositions comprising bimatoprost and methods for stimulating hair growth therewith
  • Topical compositions comprising bimatoprost and methods for stimulating hair growth therewith

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0095] Example 1: Preparation of Bimatoprost Hair Growth Gel Composition

[0096] Ethanol was weighed into a suitable medium bottle fitted for mixing, then bimatoprost was added to the ethanol and stirred at medium speed until the bimatoprost was dissolved. To a separate mixing tank add the glycerin, diethylene glycol monoethyl ether and propylene glycol and mix until the solvent is dispersed. The ethanol / bimatoprost solution was then added to the non-aqueous mixture and mixed until the components were evenly mixed (about 5 minutes of mixing). To the above mixture is added the carbomer thickener previously dispersed in water and mixed until well dispersed, once dispersed the base is added to thicken the solution into a gel. Representative formulations prepared according to the methods described above are shown in Table 3 below.

[0097] Table 3. Bimatoprost Hair Growth Topical Gel Formulations

[0098]

Embodiment 2

[0099] Example 2: In Vivo Treatment

[0100] A study was initiated to systematically evaluate the appearance of hair and eyebrows on the scalp to which bimatoprost gel formulations in Table 3 were applied. The study involved 10 subjects, 5 males, 5 females, with an average age of 70 years (range 50-94 years). Each subject was treated daily by topical application of bimatoprost from the 0.3% w / w bimatoprost formulation in Table 3.

[0101] The study was limited to subjects who had been administered bimatoprost for more than 3 months. The mean duration of exposure to the 0.3% w / w bimatoprost gel formulation was 129 days (range 90-254 days) before evaluation of parameters of hair or eyebrow growth located between control and study eyes. Observations were performed under a slit lamp biomicroscope at high magnification. Record the difference between the control and treated areas using a camera specially adapted for slit-lamp biomicroscopy.

[0102] The observations are as follo...

Embodiment 3

[0106] Example 3: Topical Cream.

[0107] 0.2% w / w bimatoprost topical cream was prepared as follows: Tegacid and spermaceti were melted together at a temperature of 70-80°C. Methylparaben was dissolved in approximately 500 gm of water and propylene glycol, polysorbate 80, bimatoprost and penetration enhancer were added sequentially, maintaining a temperature of 75-80°C. The methylparaben mixture was slowly added to the melt of Tegacid and spermaceti with continuous stirring. This addition was continued for at least 30 minutes with additional stirring until the temperature dropped to 40-45°C. Finally, enough water was added to bring the final weight to 1000 gm and the preparation was stirred to maintain homogeneity until cooled and set.

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PUM

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Abstract

Methods and compositions for stimulating the growth of hair are disclosed wherein said compositions include a cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl compound represented by the formula I wherein the dashed bonds represent the presence or absence of a double bond which can be in the cis or trans configuration and A, B, Z, X, R1 and R2 are as defined in the specification and a penetration enhancer. Such compositions are used in stimulating hair growth of human or non-human animals.

Description

[0001] related application [0002] This application claims priority to U.S. Provisional Application Serial No. 61 / 783,962, filed March 14, 2013, and is also a continuation-in-part of U.S. Application Serial No. 14 / 163,954, filed January 24, 2014, which Serial No. 14 / 163,954 is a continuation of U.S. Application Serial No. 12 / 940,711, filed November 5, 2010, which requires U.S. Provisional Application Serial No. 61 / 259,368, filed November 9, 2009 The disclosures of these applications are hereby incorporated by reference. field of invention [0003] Disclosed herein are topical compositions and methods for stimulating hair growth and treating conditions leading to hair loss, wherein the composition comprises a cyclopentaneheptanoic acid, 2-cycloalkyl or arylalkyl compound represented by Formula I and penetration enhancers: [0004] [0005] Wherein the dotted line bond indicates the presence or absence of a double bond, which can be in cis or trans configuration, and A, B,...

Claims

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Application Information

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IPC IPC(8): A61K8/42A61Q7/00A61K8/06A61P17/14
CPCA61K8/361A61K8/375A61K8/42A61P17/14A61Q7/00A61K8/34A61K8/36A61K8/37
Inventor K·沃纳K·普林C·P·普贾瑞P·萨博达尔J·T·特罗格登A·K·萨拉马陆光伟
Owner ALLERGAN INC
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