Fatty acid treatment

a technology of fatty acids and treatment methods, applied in the field of fatty acid treatment, can solve the problems of reducing the likelihood of a cure, affecting the effect of lipid metabolism,

Inactive Publication Date: 2003-01-23
LUITPOLD PHARMA INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0009] The drugs which have been used in anti-cancer chemotherapy in patients as referred to above include methotrexate, 5-fluorouracil, cyclophosphamide, cisplatin, doxorubicin, taxol and vincristine, but the invention provides a method of reducing the side effects resulting from any form of cancer chemotherapy resulting from drugs in any one of the classes mentioned below, or drugs similar to them which may be developed in the future:

Problems solved by technology

Most chemotherapy regimes, other than those primarily targeted at the endocrine system such as anti-oestrogens and antiandrogens, cause important side effects.
Each drug has a specific range of side effects, some of which may be particularly important and limit the dose of the drug which can be given and so reduce the likelihood of a cure.
Doxorubicin and related compounds, for example, can be severely cardiotoxic and this is a common dose-limiting side effect.
Bleomycin, and to a lesser extent cyclophosphamide, can be toxic to the lungs causing fibrosis.
The platinum derivatives and related compounds may be very toxic to the nerves.
A major effect of this compound is to damage the islet cells of the pancreas and consequently to lead to insulin dependent diabetes.

Method used

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Examples

Experimental program
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Embodiment Construction

[0025] The chemotherapy drugs can be administered in the manner conventional for each drug, itself known and no part of the invention. The fatty acids may be in any convenient form and the following are examples, suited also to the other fatty acids discussed.

[0026] 1. Administration of 500 mg to 20 g of GLA per day in the form of soft or hard gelatine capsules or tablets providing:

[0027] a. 40 to 80 mg per capsule of GLA in the form of evening primrose oil.

[0028] b. 50-150 mg per capsule of GLA in the form of borage, blackcurrant, fungal or other appropriate oil.

[0029] c. 100-500 mg GLA per capsule in the form of triglyceride GLA, or any appropriate salt of GLA, such as the lithium or calcium or magnesium or zinc or potassium salts.

[0030] 2. Administration of DGLA in a dose of 500 mg to 20 g per day in the forms of 1 g above.

[0031] 3. Administration of GLA or DGLA in association with EPA, with or without DHA, for example as a 40 to 80 mg GLA per capsule in the form of evening primr...

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Abstract

The use in preparation of a medicament for treating and preventing the side effects of anti-cancer chemotherapy of a polyunsaturated fatty acid with a carbon chain length of 14 to 26 and with 2 to 6 double bonds in the molecule in cis or trans configuration, and a method of such treatment or prevention wherein said fatty acid is used as an active.

Description

[0001] The invention relates to fatty acid treatment.[0002] Chemotherapy, the use of drugs which aim either to kill cancer cells or to stop the spread of cancer, is now one of the most widely used types of treatment for cancer. It may be used either alone or in combination with one of the other modalities of cancer treatment, usually surgery or radiotherapy. Most chemotherapy regimes, other than those primarily targeted at the endocrine system such as anti-oestrogens and antiandrogens, cause important side effects. These side effects differ from drug to drug, but it is now common to use two, three, four or more drugs in combination in chemotherapy regimes and so most chemotherapy-treated patients will experience one or more of the typical consequences. The side effects include nausea, vomiting, suppression of the immune system, suppression of white blood cells and platelets, hair loss, cardiovascular damage, lung damage, renal damage, nerve damage and marked fatigue and malaise. Eac...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61P35/00A61K31/201A61K31/202
CPCA61K31/201A61K31/202A61P35/00
Inventor SCOTT, CATHERINE A.HORROBIN, DAVID F.
Owner LUITPOLD PHARMA INC
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