83 results about "Allylic alcohol" patented technology

The invention relates to carboxylic acid polymer which is an admixture of concrete which can control the slump loss of the concrete. Hydroxyl bifunctional polyether esterifies with bifunctional maleic or the acid anhydride of maleic to produce crosslinked large monomer, and copolymerizes with allylic alcohol ether and bifunctional small monomer to produce certain molecular weight polymer. The water-reducing agent can incessantly release small molecular weight water-reducing agent during the hydration of the cement, thereby the goal of continuously restraining slump loss is achieved.

A single-site catalyst is disclosed. The catalyst comprises a transition metal complex, an activator, and an allylic alcohol-containing polymer. The catalyst has high activity and great capability to incorporate higher α-olefins into polyethylene. The polyethylene produced has high molecular weight and low density.

The invention provides a preparation method of lily-of-the-valley pyran by using a static bed loaded with a solid superacid catalyst. The method comprises the steps of selection of a static bed, weighing of raw materials, feeding of the raw materials and reaction in the static bed; in the step of weighing of the raw materials, the mass ratio of isovaleraldehyde to allylic alcohols is 1 to 0.93-1; in the step of reaction in the static bed, for the static bed loaded solid superacid catalyst, the length ranges from 80 cm to 280 cm, the gas flow rate ranges from 0.2 m / s to 3 m / s, and the pressure ranges from 0.015 MPa to 0.3 MPa. According to the preparation method, static bed loaded solid superacid serves as the catalyst to prepare the lily-of-the-valley pyran for the first time, the product yield is high, according to the allylic alcohols, the yield ranges from 95.1% to 96.3%, and according to the isovaleraldehyde, the yield ranges from 80.2% to 86.2%; the content of a gas phase of a product is over 99%; the method has the advantages of being good in selectivity, high in reaction efficiency, long in service life, less in amount of three wastes and the like, and the raw material product is prone to separation.

The invention discloses a silica-supported lithium phosphate catalyst and a preparation method thereof. The catalyst, with hollow nano silica microsphere as a carrier and loaded with basic lithium phosphate, can be used for gas phase isomerization of epoxy propane. The preparation method is as below: preparing a nano hollow spherical silica microsphere with high specific area by using functionalized polystyrene as a template; preparing basic lithium phosphate by using a water solution containing lithium and alkali metal ions and a water solution containing phosphate ions; and then loading the lithium phosphate onto the silica microsphere to prepare the supported catalyst. The obtained silica supported lithium phosphate catalyst can be used in reaction for isomerization of epoxy alkane into corresponding allylic alcohol, and has higher conversion rate and selectivity at low temperature.

The invention provides a preparation method of allyl alcohol. The preparation method comprises the steps of reacting acetaldehyde or propaldehyde with formaldehyde under the existence of a heterogeneous catalyst to obtain allyl aldehyde, wherein the allyl aldehyde is allyl aldehyde or methyl allyl aldehyde; reacting allyl aldehyde or methyl allyl aldehyde with hydrogen gas under the existence of a catalyst to obtain the allyl alcohol, wherein the allyl alcohol is allyl alcohol or 2-methyl allyl alcohol. The method has simple process, low cost, few byproducts, good selectivity and high yield.

The present invention provides a method to effectively inhibit the oxidization of VO(acac)2 in solution for months. It is believed that VO(acac)2 forms a π-complex with as many as three allylic alcohols which precludes reaction with any oxygen in the system. Although saturated and homo-allylic alcohols were also tested, this effect appears only in the allylic-alcohol based solutions. This ability to inhibit oxidation of VO(acac)2 allows these solutions to be used for making thermochromic VO2 film much more easily and economically as it avoids the requirement of operating under low oxygen level conditions. Thus the present invention provides a method of stabilizing vanadium oxyacetylacetonate (VO(acac)2) in solution against oxidation for extended periods of time, comprising the steps of mixing the oxyacetylacetonate precursor in an allylic alcohol prior to spin-coating for VO2 film formation. The allylic alcohol may be (β-methallyl alcohol. Alternatively, the allylic alcohol may be any one of 4-buten-2-ol, 2-buten-1-ol, 1-penten-3-ol, 2-hexen-1-ol and 1-hexen-3-ol.

A UV-curable composition is disclosed. The composition comprises a crosslinking agent, a hydroxyalkyl acrylate or methacrylate, and an acrylic polyol. The crosslinking agent is selected from the group consisting of multifunctional isocyanates, melamines, and silanes. The acrylic polyol comprises recurring units of an allylic alcohol. The composition can be irradiated to be solidified and then fully cured by the urethane, melamine, or silane reactions. Alternatively, the composition can be cured by the urethane, melamine, or silane reactions, and then fully cured by radiation. The invention provides low VOC but high performance coatings. More importantly, the invention provides a UV-curable system without the need for acrylated oligomers.

The present invention relates to new compositions and reactions to produce allylic alcohols or precursors of allylic alcohols (e.g., silyl ethers of allylic alcohols). Methods of the invention may comprise combining an alkene and an aldehyde in the presence of a transition metal catalyst (e.g., a nickel catalyst) to form an allylic alcohol or precursor of an allylic alcohol. Reaction products of the present invention may be valuable as intermediates and / or products in pharmaceutical and polymer research. Also, methods of the invention may be useful as fragment coupling reactions in complex molecule synthesis. Moreover, methods of the invention may include the use of reagents which, under reaction conditions known in the art, may have been unreactive, i.e., may not have been able to form the reaction product. The reagents used in the present invention may be relatively lower in cost than in other methods. Also, methods of the invention may reduce the number of synthetic and purification steps required to produce the reaction products, as well as reducing time, cost, and waste production.

A new method for preparing lithium phosphate catalysts is disclosed. The method comprises precipitating a lithium phosphate from a mixture comprising a first aqueous solution which contains lithium and sodium ions and a second aqueous solution which contains phosphate and borate ions. The resultant lithium phosphate catalyst has increased activity and selectivity in the isomerization of an alkylene oxide to the corresponding allylic alcohol.

The present invention relates to new compositions and reactions to produce allylic alcohols or precursors of allylic alcohols (e.g., silyl ethers of allylic alcohols). Methods of the invention may comprise combining an alkene and an aldehyde in the presence of a transition metal catalyst (e.g., a nickel catalyst) to form an allylic alcohol or precursor of an allylic alcohol. Reaction products of the present invention may be valuable as intermediates and / or products in pharmaceutical and polymer research. Also, methods of the invention may be useful as fragment coupling reactions in complex molecule synthesis. Moreover, methods of the invention may include the use of reagents which, under reaction conditions known in the art, may have been unreactive, i.e., may not have been able to form the reaction product. The reagents used in the present invention may be relatively lower in cost than in other methods. Also, methods of the invention may reduce the number of synthetic and purification steps required to produce the reaction products, as well as reducing time, cost, and waste production.

Novel substituted 1,2,4-trioxanes and 1,2,4-trioxepanes useful as anti-malarial and / or anticancer agents, and an improved method for their preparation, preferably involving a thiol-olefin co-oxygenation (TOCO) reaction between an allylic alcohol and a ketone.

The present invention relates to processes for epimerising alcohols of compounds having a hydroxyl substituent on an asymmetric allylic carbon, such as compounds useful for the synthesis of vitamin D analogues where the epimeric hydroxyl substituent is at the 24 position. The Invention further relates to methods of producing intermediates useful for the synthesis of calcipotriol by said epimerisation processes.

The invention provides an organic silicon coupling agent containing beta-dicarbonyl, which belongs to the field of organic chemical synthesis. As the organic coupling agent has a beta-dicarbonyl functional group, the dicarbonyl in the structure has a coordination chelating function, is conductive to generation of coplanar acting force and increase of adhesive property, thereby further solving the application problem that fluorubber and fluorosilicone rubber are difficult to adhere; and the organic silicon coupling agent can be used for preparing special silicon oil and silicon resin. The preparation method of the organic silicon coupling agent comprises the following steps of reacting a compound containing the beta-dicarbonyl with allyl chloride under the catalysis of potassium carbonate to synthesize an allyl compound containing the beta-dicarbonyl, and then performing addition with siloxane under the catalysis of a platinum metal complex. The preparation method is simple in process and post-treatment, convenient to operate, high in yield, low in cost and easy for industrialization; and since the allylated beta-dicarbonyl compound is catalyzed by potassium carbonate, the traditional high-temperature reaction of allylic alcohol under catalysis of a high-toxicity precious metal is avoided, energy consumption is reduced, the operation is facilitated and the cost is reduced.

The present invention relates to processes for epimerising alcohols of compounds having a hydroxyl substituent on an asymmetric allylic carbon, such as compounds useful for the synthesis of vitamin D analogues where the epimeric hydroxyl substituent is at the 24 position. The invention further relates to methods of producing intermediates useful for the synthesis of calcipotriol by said epimerisation processes.

The invention provides a synthesis method of a trisubstituted phosphine oxide compound or a trisubstituted phosphine oxide compound. The method uses cheap, easy-to-obtain, wide-sourced, stable and low-toxic alcohols or diols as alkylating agents, uses cheap and easily-available iodine salts as catalysts, and directly obtains trisubstituted phosphine oxides or dioxanes through selective reactions without solvents. Phosphine compounds. The reaction method is simple, the conditions are mild, no solvent is needed, and the operation is easy. The method has lower requirements on reaction conditions, can use benzyl type, allyl type and aliphatic alcohols as alkylating reagents, can realize the synthesis of target phosphine oxide compounds, and has a wide application range. This method can also be easily scaled up to 20 times for production, and the gram-level preparation of the product should be carried out, so it should also have certain research and industrial application prospects.

The invention discloses a method for synthesizing hydrophilic antibacterial special silicone oil. The method comprises the following steps: preparing a mixture from 200 kg of low-hydrogen silicone oil, 25-200 kg of allyl epoxy polyether, 30-240 kg of an allyl alcohol and a certain amount of isopropyl alcohol T, and adding the mixture into a 1000 kg reaction kettle, wherein the weight of the isopropanol T is 5-10% of the total weight of the mixture; heating the reaction kettle to 55 DEG C, and adding 2-5 g of chloroplatinic acid; keeping the temperature for 3-6 h; adding 4.5-13.5 kg of alkyl carboxylate, 5-15 kg of a coupling agent and ethylene glycol monobutyl ether accounting for 0-10% of the total weight of the material in the reaction kettle into the reaction kettle; and carrying out areaction at 80-100 DEG C for 6 h to obtain the colorless or pale yellow and transparent hydrophilic antibacterial special silicone oil. The hydrophilic antibacterial special silicone oil of the invention is applied to textiles to make the textiles have good hydrophilicity, good antibacterial ability, comfortable feeling and stable wearing experience.

The invention provides a method for continuously preparing linalool from allylic alcohol by an isomerization process. The method comprises the following steps: preparing a vanadium-amine complex catalyst, adding a reacting product and a catalyst, controlling isomerization reaction conditions, constantly adding the reacting product, and constantly rectifying, wherein the vanadium-amine complex catalyst is prepared by adding 1 part by weight of xylene, 0.01-0.1 part by weight of a vanadium compound and 0.01-0.1 part by weight of nitrogen base, starting to stir and heat, insulating for 1-3 hours at 140 DEG C, cooling to below 50 DEG C, and filtering to reclaim the catalyst. According to the method, the catalyst system has high reaction selectivity, the selectivity of linalool is 93.2-96.2 percent, the yield of linalool is 92.7-94.5 percent, the scrap rate is 2.7-4.0 percent, and the linalool content is 98.5-98.7 percent. The catalyst has low unit consumption.

A synthetic method of the all trans long chain terpene primary alcohol is provided, which belongs to the technology field of the organic synthesis. The invention uses the cheap and easily gained geraniol, 2-allylic alcohol or the long chain terpene primary alcohol synthesized by the method as initial materials and uses the ethylenic chlorination reaction happened between the terpene primary alcohol acetate and the lime chlorite to form double bonds and the coupling reaction between the benzene sulphinate ester and the allyl chloride under alkali condition as the key steps, and gain the products through the hydrolysis reaction of the benzene removal sulphinate group and ester of the coupling product. The invention fully utilizes the complete framework of the primary alcohol and adds one or a plurality of isopentene units via coupling and synthesizes series of long chain terpene primary alcohol, which fully embodies the synthesis conception of the atomic economy; only a novel double bonds is formed in the reaction and other double bonds are the all trans double bonds in the raw materials, thereby ensures the trans configuration of the double bonds in the generated long chain terpene primary alcohol to the greatest extent. The invention has moderate reaction condition, simple synthetic route, simple operation, good reaction selectivity, high productive rate, easy separation and purification of the products and small environmental pollution.

A composition for use as an reactive diluent is prepared by reacting an allylic alcohol with an epoxide in the presence of a suitable catalyst to form a hydroxy ether, which is further reacted with an aldehyde or a carboxylic acid or derivative using a catalyst that does not induce undue polymerization or rearrangement to form- an ether ester or -acetal- composition useful as an reactive diluent.

A method of reducing a C—O bond to the corresponding C—H bond in a substrate, which could be a benzylic alcohol, allylic alcohol, ester or an ether bond beta to a hydroxyl group or alpha to a carbonyl group using a recyclable metal catalyst system. The recyclable catalyst system is also applicable to reducing a C═O bond to the corresponding C—OH bond and then C—H bond. These methodologies can be linked in one-pot to selective oxidation and depolymerizations of aromatic polyols such as lignin.

A process for producing allylic ether compounds in presence of a catalyst comprising at least one Cu(II) salt by reaction of an allylic alcohol with either itself or another alcohol.

The invention relates to a preparation method of N-allyl arylamine. The method comprises the following steps: firstly, sequentially adding allyl alcohol compounds, aromatic amine compounds, a promoter and a catalyst into a reaction solvent; and after the obtained mixture is reacted for 5-14 hours under the reflux temperature condition of 50-100 DEG C, evaporating partial solvent under reduced pressure, thereby obtaining crude reaction liquid; carrying out extraction on the rough reaction liquid by using diethyl ether so as to obtain extract liquor; and finally, drying the extract liquor until the extract liquor is constant in weight, and then carrying out column chromatography isolation on the obtained product. According to the invention, a catalyst system is simple, and no ligand is required, and N-allyl arylamine is cheap and easy to take; and the method is mild in reaction conditions, short in reaction time, simple in post-treatment, high in yield and good in selectivity, and therefore, the method is an environment-friendly green synthesis technology, and has a good industrial application prospect.

The invention relates to a preparation method of an inflammation-response guided tissue regeneration membrane, which belongs to the field of the surface modification of materials. An anti-inflammation drug with hydroxyl is bonded to the surface of a membrane by adopting an ester bond, carry out selective enzymolysis on the ester bond by utilizing cholesterol esterase concentrated released by macrophage when the inflammation occurs, and a responsive release effect is achieved. The method comprises the following steps: initiating by virtue of ultraviolet rays, and introducing ITXSP (isopropylthioxanthone semipinacol) into the surface of the membrane; simultaneously adding an initiator, a cross-linking agent and an allylic alcohol monomer into the activated ITXSP surface to form a hydrogel layer; enabling the drug to react with the allylic alcohol monomer to form a drug molecule containing an ester group and carbon-carbon double bond; and finally thermally initiating the drug molecule, the allylic alcohol monomer and the cross-linking agent, loading a gel layer containing the drug, wherein the drug is fixed in the membrane surface gel layer by virtue of the ester group. The inflammation-response membrane has the characteristics of excellent biological compatibility and inflammation-response drug release.

The invention provides a phosphamide derivative, a preparation method thereof and application of the phosphamide derivative in catalytic rearrangement reaction, the structural formula of the phosphamide is shown in the specification, R1 is independently selected from aryl and heteroaryl, and R2 is selected from alkyl, alkenyl, alkynyl, aryl and heteroaryl. The preparation method of the phosphamidecompound is obtained by one-pot reaction of phosphorus oxychloride, phenol and sulfonamide, and compared with a known literature report method, the preparation method has the advantages that the operation is simplified, and the synthesis yield is increased. The phosphamide compound is easily dissolved in an organic solvent, has very strong acidity, can be used for catalyzing rearrangement reaction, and is successfully applied to the rearrangement reaction between allyl alcohol and 2-alkoxy propylene to quickly and efficiently synthesize a gamma, delta-unsaturated ketone product.

A new method for preparing lithium phosphate catalysts is disclosed. The method comprises precipitating a lithium phosphate from a mixture comprising a first aqueous solution which contains lithium and sodium ions and a second aqueous solution which contains phosphate and borate ions. The resultant lithium phosphate catalyst has increased activity and selectivity in the isomerization of an alkylene oxide to the corresponding allylic alcohol.

A process for producing allylic ether compounds in presence of a catalyst comprising at least one Cu(II) salt by reaction of an allylic alcohol with either itself or another alcohol.

The invention relates to a method for preparing a natural alkaloid indoline and pyrrolidine compound (full name is 3a-allyl-1,2,3,3a,8,8a-hexahydro-pyrrole [2,3-b] indole-2-methyl formate, and the structural formula is shown in formula I). The structure formula I is as shown in the specification. The preparation method mainly comprises the following step: under combined catalysis of a stable zero-valent palladium complex, triphenylphosphine and lewis acid, preparing a target compound shown in the formula I from a compound shown in a formula II and derivatives (for example, a compound shown in a formula III) of allylic alcohols by serial reactions of allylation, amination and the like. Compared with the existing method for preparing the compound I, the method has the advantages of being convenient to operate, less in dosage of catalyst, low in cost, concise in step, high in product yield and the like.

The invention provides a method for preparing a beta, gamma-unsaturated carboxylic acid compound. The method comprises the steps of making an allylic alcohol compound of a formula 1 or a formula 2 react with formic acid in the presence of a palladium catalyst, a phosphorous ligand, acid anhydride and an organic solvent to obtain the beta, gamma-unsaturated carboxylic acid compound of a formula 3 or formula 4, wherein R1, R2 and R3 are defined in the description. Formic acid is utilized as a carboxylation reagent, and the beta, gamma-unsaturated carboxylic acid compound is low in price, safe, stable and low in toxicity; the yield is high, the operation is simple, and the economy is high; compared with an existing compounding method, the use of toxic gas carbon monoxide and / or an equivalent quantity of reactive metal reagents is avoided, and the method meets requirements for environment-friendly chemistry; in addition, the dose of catalysts is small, the reaction condition is mild, the reactant is high in conversion rate and product yield, and the method has a very good industrial prospect.