Preparation method of inflammation-response guided tissue regeneration membrane

An inflammation and initiator technology, applied in the field of preparation of inflammatory response type releasing anti-inflammatory drug film, can solve the problem of inability to prevent and suppress individual differences

Active Publication Date: 2017-09-29
北京市创伤骨科研究所 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the radiotherapy or oral NSAIDs currently used are generally intervened in the perioperative period, which cannot prevent and suppress inhibition according to individual differences.

Method used

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  • Preparation method of inflammation-response guided tissue regeneration membrane
  • Preparation method of inflammation-response guided tissue regeneration membrane
  • Preparation method of inflammation-response guided tissue regeneration membrane

Examples

Experimental program
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Effect test

Embodiment 1

[0038] (1) On the surface of electrospun porous polyurethane (PU), apply a saturated solution of ITX acetone on the surface of polyurethane, cover the surface of polyurethane, cover with a quartz plate, and irradiate with ultraviolet light for 10 minutes (wavelength 200nm, irradiation distance 50mm ), the ITXSP functional group was introduced into the surface of polyurethane (PU) membrane (thickness 100 μm, average pore size 1 μm).

[0039] (2) Carried out by N-hydroxyethylacrylamide (HEMAA) and indomethacin (IDCM) under the catalysis of DCC / DMAP (N, N'-dicyclohexylcarboimide / 4-dimethylaminopyridine) Esterification reaction to obtain monomers containing drugs, ester bonds and double bonds. The molar ratio of the reaction monomer to the initiator is IDCM:HEMAA:DCC:DMAP=1:3:3:0.5, the solvent is anhydrous DMF, the reaction temperature is 40°C, and the reaction time is 24h. First add other raw materials except DCC at one time, then add DCC under ice bath conditions, and continue...

Embodiment 2

[0043] (1) On the surface of electrospun porous polyurethane (PU), apply a saturated solution of ITX acetone on the surface of polyurethane, cover the surface of polyurethane, cover with a quartz plate, and irradiate with ultraviolet light for 10 minutes (wavelength 400nm, irradiation distance 50mm ), introducing ITXSP functional groups to the surface of polyurethane (PU) membrane (thickness 1mm, average pore size 10 μm);

[0044] (2) Carried out by N-hydroxyethylacrylamide (HEMAA) and indomethacin (IDCM) under the catalysis of DCC / DMAP (N, N'-dicyclohexylcarboimide / 4-dimethylaminopyridine) Esterification reaction to obtain monomers containing drugs, ester bonds and double bonds. The molar ratio of the reaction monomer to the initiator is IDCM:HEMAA:DCC:DMAP=1:3:3:0.5, the solvent is anhydrous DMF, the reaction temperature is 40°C, and the reaction time is 24h. First add other raw materials except DCC at one time, then add DCC under ice bath conditions, and continue the ice b...

Embodiment 3

[0048] (1) On the surface of electrospun porous polyurethane (PU), apply a saturated solution of ITX acetone on the surface of polyurethane, cover the surface of polyurethane, cover with a quartz plate, and irradiate with ultraviolet light for 10 minutes (wavelength 350nm, irradiation distance 50mm ), introducing ITXSP functional groups to the surface of polyurethane (PU) membrane (thickness 0.5mm, average pore size 6μm);

[0049] (2) Carried out by N-hydroxyethylacrylamide (HEMAA) and indomethacin (IDCM) under the catalysis of DCC / DMAP (N, N'-dicyclohexylcarboimide / 4-dimethylaminopyridine) Esterification reaction to obtain monomers containing drugs, ester bonds and double bonds. The molar ratio of the reaction monomer to the initiator is IDCM:HEMAA:DCC:DMAP=1:3:3:0.5, the solvent is anhydrous DMF, the reaction temperature is 40°C, and the reaction time is 24h. First add other raw materials except DCC at one time, then add DCC under ice bath conditions, and continue the ice b...

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Abstract

The invention relates to a preparation method of an inflammation-response guided tissue regeneration membrane, which belongs to the field of the surface modification of materials. An anti-inflammation drug with hydroxyl is bonded to the surface of a membrane by adopting an ester bond, carry out selective enzymolysis on the ester bond by utilizing cholesterol esterase concentrated released by macrophage when the inflammation occurs, and a responsive release effect is achieved. The method comprises the following steps: initiating by virtue of ultraviolet rays, and introducing ITXSP (isopropylthioxanthone semipinacol) into the surface of the membrane; simultaneously adding an initiator, a cross-linking agent and an allylic alcohol monomer into the activated ITXSP surface to form a hydrogel layer; enabling the drug to react with the allylic alcohol monomer to form a drug molecule containing an ester group and carbon-carbon double bond; and finally thermally initiating the drug molecule, the allylic alcohol monomer and the cross-linking agent, loading a gel layer containing the drug, wherein the drug is fixed in the membrane surface gel layer by virtue of the ester group. The inflammation-response membrane has the characteristics of excellent biological compatibility and inflammation-response drug release.

Description

technical field [0001] The invention belongs to the field of material surface modification, and in particular relates to a preparation method of an inflammation-responsive release anti-inflammatory drug film. Background technique [0002] Heterotopic ossification (HO) refers to the appearance of mature lamellar bone in the soft tissue around the joint. Complications such as complex regional pain syndrome, joint stiffness, and nerve entrapment can occur. So far, the pathogenesis of HO is still unclear. However, existing studies suggest that the formation of heterotopic bone is related to the improper differentiation of mesenchymal stem cells into osteoblasts in soft tissues. For postoperative heterotopic bone formation, changes in the local environment triggered by local inflammatory responses are crucial factors driving this inappropriate differentiation 【1】 . [0003] HO is one of the most common complications after total disc replacement (TDR). A meta-analysis of the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/54A61L27/18A61L27/56C08J7/18C08L75/04C08L83/04
CPCA61L27/18A61L27/54A61L27/56A61L2300/216A61L2300/41A61L2430/38C08J7/18C08J2375/04C08J2383/04C08L75/04C08L83/04
Inventor 石锐田伟
Owner 北京市创伤骨科研究所
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