Method for preparing beta, gama-unsaturated carboxylic acid compound

A technology for compounds and carboxylic acids, applied in the field of compound synthesis, to achieve the effects of high yield, high conversion rate of reactants, and easy operation

Inactive Publication Date: 2017-11-10
UNIV OF SCI & TECH OF CHINA
View PDF2 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In view of this, the object of the present invention is to solve one or more pro

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for preparing beta, gama-unsaturated carboxylic acid compound
  • Method for preparing beta, gama-unsaturated carboxylic acid compound
  • Method for preparing beta, gama-unsaturated carboxylic acid compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Embodiment 1: Preparation (E)-4-phenylbut-3-enoic acid

[0042] The reaction conditions are as follows:

[0043]

[0044] The operation process is as follows:

[0045] Add tris(dibenzylidene indeneacetone)dipalladium (Pd 2 (dba) 3 , 0.5mol%, 2.3mg), 4,5-bisdiphenylphosphine-9,9-dimethylxanthene (xantphos, 2.0mol%, 5.8mg). The air in the tube was completely replaced with argon three times, and then 1 mL of toluene, cinnamyl alcohol (0.50 mmol, 67 mg), formic acid (1.5 mmol, 69 mg) and acetic anhydride (1.5 mmol, 152 mg) were added under an argon atmosphere. After the reaction tube was sealed, the reaction system was heated to 80°C in an oil bath and stirred continuously for 12 hours (IKA magnetic stirrer, RCT basic type, stirring speed 500 rpm). After the reaction was completed, the system was cooled to room temperature. The reaction solution was diluted with ethyl acetate, and then the diluted reaction solution was concentrated by rotary evaporation (BUCHI Co., ...

Embodiment 2

[0049] Example 2: Preparation of (E)-4-(4-methoxyphenyl)but-3-enoic acid

[0050] The reaction conditions are as follows:

[0051]

[0052] The operation process is the same as that of Example 1, white solid with a yield of 78% and a purity of >99%.

[0053] The (E)-4-(4-methoxyphenyl)but-3-enoic acid obtained in Example 2 is analyzed by nuclear magnetic resonance, and the results are as follows:

[0054] 1H NMR (400MHz, CDCl3) δ7.31(d, J=8.8Hz, 2H), 6.85(d, J=8.8Hz, 2H), 6.46(d, J=15.9Hz, 1H), 6.14(dt, J =15.8,7.1Hz,1H),3.80(s,3H),3.27(dd,J=7.2,1.4Hz,2H);

[0055] 13C NMR (101 MHz, CDCl3) δ 177.8, 159.4, 133.5, 129.6, 127.6, 118.7, 114.1, 55.4, 38.1.

Embodiment 3

[0056] Example 3: Preparation of (E)-4-(4-fluorophenyl)but-3-enoic acid

[0057] The reaction conditions are as follows:

[0058]

[0059] The operation process is the same as that of Example 1, white solid with a yield of 85% and a purity of >99%.

[0060] The (E)-4-(4-fluorophenyl)but-3-enoic acid obtained in Example 3 is analyzed by nuclear magnetic resonance, and the results are as follows:

[0061] 1H NMR (400MHz, CDCl3) δ7.34 (m, 2H), 7.00 (m, 2H), 6.48 (d, J = 15.9Hz, 1H), 6.20 (dt, J = 15.8, 7.1Hz, 1H), 3.29 (dd,J=7.1,1.2Hz,2H);

[0062] 13C NMR (101 MHz, CDCl3) δ 178.2, 162.5, 133.0, 132.9, 128.0, 120.6, 115.62, 38.1.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention provides a method for preparing a beta, gamma-unsaturated carboxylic acid compound. The method comprises the steps of making an allylic alcohol compound of a formula 1 or a formula 2 react with formic acid in the presence of a palladium catalyst, a phosphorous ligand, acid anhydride and an organic solvent to obtain the beta, gamma-unsaturated carboxylic acid compound of a formula 3 or formula 4, wherein R1, R2 and R3 are defined in the description. Formic acid is utilized as a carboxylation reagent, and the beta, gamma-unsaturated carboxylic acid compound is low in price, safe, stable and low in toxicity; the yield is high, the operation is simple, and the economy is high; compared with an existing compounding method, the use of toxic gas carbon monoxide and/or an equivalent quantity of reactive metal reagents is avoided, and the method meets requirements for environment-friendly chemistry; in addition, the dose of catalysts is small, the reaction condition is mild, the reactant is high in conversion rate and product yield, and the method has a very good industrial prospect.

Description

technical field [0001] The invention relates to the field of compound synthesis, in particular to a method for preparing β, γ-unsaturated carboxylic acid compounds by palladium-catalyzed reaction of formic acid and allyl alcohol. Background technique [0002] β,γ-unsaturated carboxylic acid compounds are very important intermediates in biomedicine, organic synthesis and chemical industry. [0003] About the synthetic method of β, γ-unsaturated carboxylic acid compounds, Ruth Naigre and Howard Alper's article (Palladium clay catalyzed regio-and stereospecific synthesis of β, γ-unsaturated acids by the carbonylation of allylic alcohols, Ruth Naigre and Howard Alper, Journal of The method disclosed in Molecular Catalysis A:Chemical 111 (1996) 11-15) utilizes carbon monoxide as carboxylation raw material, needs high carbon monoxide pressure in its reaction system, and carbon monoxide toxicity is big simultaneously, and operation is dangerous and difficult. [0004] In addition,...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): C07B37/04C07C51/353C07C57/42C07C57/60C07C59/64C07C59/66C07C67/313C07C69/76C07C253/30C07C255/57C07C319/20C07C323/62C07C67/297C07C69/24C07F5/04C07D333/24C07D307/54
CPCC07B37/04C07C51/353C07C57/42C07C57/60C07C59/64C07C59/66C07C67/297C07C67/313C07C69/24C07C69/76C07C253/30C07C255/57C07C319/20C07C323/62C07D307/54C07D333/24C07F5/04
Inventor 傅尧付明臣尚睿吴雅楠
Owner UNIV OF SCI & TECH OF CHINA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap