Drug-loaded mesoporous-silica-reinforced dental binder and preparation method thereof

A technology of mesoporous silica and binder, which is used in dental preparations, medical science, pharmaceutical formulations, etc., can solve problems such as dental implants with no mesoporous materials, and achieve treatment and bacterial infection, and defense against bacterial infection. Effect

Inactive Publication Date: 2014-03-26
SHANGHAI NAT ENG RES CENT FORNANOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are no reports of mesoporous materials filled with adhesives or dental implants

Method used

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  • Drug-loaded mesoporous-silica-reinforced dental binder and preparation method thereof
  • Drug-loaded mesoporous-silica-reinforced dental binder and preparation method thereof
  • Drug-loaded mesoporous-silica-reinforced dental binder and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] The preparation method of amine-modified mesoporous silica was as follows: a certain amount of CTAB was dissolved in 180 mL water, stirred for 15 minutes, and then 6 mmol NaOH was added. With vigorous stirring, TEOS was added dropwise. The molar ratio of CTAB to TEOS is 0.01:1. The reactant was slowly stirred for 10 hours at 25°C, and the obtained reaction product was aged at room temperature for 12 hours, washed with double distilled water, dried in vacuum at 80°C for 12 hours, and finally calcined in a dry air atmosphere at 550°C for 6 Hour. Take 1 g of the product and disperse it in 100 mL of toluene solution, add 2 mL of APTES, and reflux at 60°C for 24 hours. The product was washed three times with toluene, methanol and water respectively, and dried naturally at room temperature to obtain MCM-41, as figure 1 shown.

Embodiment 2

[0031] The preparation method of 4-META-modified MCM-41: take a certain amount of MCM-41 obtained in Example 1 and ultrasonically disperse it in water for later use. Add equimolar 4-META and APTES into 50mL DMSO, and add NHS and EDC equimolar to chelating agent after completely dissolving, stir at room temperature for 24 hours, then add the aqueous dispersion of mesoporous silica dropwise. After mixing and stirring for 24 hours, the product was filtered, washed several times with absolute ethanol, and dried under vacuum to obtain 4-META-modified mesoporous silicon (MCM-META). like figure 2 Shown are the infrared spectra of MCM-41 and MCM-META, indicating that the surface of mesoporous silica has been successfully modified with 4-META.

Embodiment 3

[0033] The preparation method of drug-loaded 4-META modified MCM-41: 1.5 g of ibuprofen was dissolved in 50 mL of hexane, and then 1.5 g of 4-META modified mesoporous silicon obtained in Example 1 was soaked in ibuprofen in hexane solution, then the product was filtered and washed several times, and dried for 24 hours to obtain drug-loaded mesoporous silicon.

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Abstract

The invention relates to a drug-loaded mesoporous-silica-reinforced dental binder and a preparation method thereof. The binder comprises following components by weight: 40-60% of a resin component, 35-50% of a dilution component, 2-10% of an acid monomer, 0.2-0.5% of a photoinitiator, 0.1-0.3% of a promoter, a trace amount of a polymerization inhibitor and 1-10% of mesoporous silica. The binder has high strength and drug releasing property, and therefore the binder is advantaged by loading and performing controlled releasing of antibacterial agents, anti-inflammatory drugs, hemostatics, etc.. The binder not only has a binding function, but also has certain functions of treating and preventing bacterial infection, and can be used as a dentine binder in clinic.

Description

technical field [0001] The invention relates to a preparation method of a dental adhesive widely used in the dental medical field, in particular to a preparation method of a drug-loaded mesoporous silica-reinforced dental adhesive. The method belongs to the preparation technology of nanometer material and composite material thereof, and the prepared material can be widely used in fields such as biology and medicine. Background technique [0002] The bond strength of the adhesive is an important indicator for judging whether the adhesive is good or bad, and its strength depends on the good wettability of the adhesive and the tightness of the repair interface. The addition of nanomaterials has become an important means to enhance the bond strength of adhesives. For example, 3M has developed the Adper Seingle Bond 2, a nano-scale fully acid-etched single-bottle adhesive, which is based on the Ader Single Bond with good clinical performance, and contains evenly distributed nano...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K6/083A61K47/48A61K31/192A61K31/4164A61K31/5383A61K31/43A61P1/02A61P31/04
Inventor 周涓朱君钟建何丹农
Owner SHANGHAI NAT ENG RES CENT FORNANOTECH
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