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Sea cucumber saponin, preparation method thereof and application thereof in food or medicine

The technology of sea cucumber saponins and sea cucumber is applied in the field of functional food and medicine and its preparation, and achieves the effects of less pollution, reducing fat accumulation and inhibiting weight gain.

Inactive Publication Date: 2011-08-17
OCEAN UNIV OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, people's research on the physiological activity of sea cucumber saponins has mainly focused on antitumor aspects, and there has been no report on the weight loss effect of sea cucumber saponins

Method used

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  • Sea cucumber saponin, preparation method thereof and application thereof in food or medicine
  • Sea cucumber saponin, preparation method thereof and application thereof in food or medicine
  • Sea cucumber saponin, preparation method thereof and application thereof in food or medicine

Examples

Experimental program
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Effect test

experiment example 1

[0035] Experimental Example 1: The weight loss effect of sea cucumber saponins on obese mice.

[0036] The experimental animals were C57 / BL6 mice, male, weighing 19-21 g, purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd., license number: SCXK (Beijing) 2009-0007. The C57 / BL6 mice were randomly divided into 4 groups according to body weight: low-fat control group, high-fat obesity group, low-dose sea cucumber saponin group, and high-dose sea cucumber saponin group, with 10 mice in each group, and fed with corresponding feeds.

[0037] The animal feeds of each group were prepared by themselves, among which the protein content of the low-fat control group was 20%, the fat content was 5%, the starch was 65%, and the mineral mixture and vitamin complex were all referred to the AIN-93 formula; while the protein content of the high-fat group feed was The content is 20%, the fat content is 25%, the starch content is 15%, the sucrose content is 20%, and the ...

Embodiment 2

[0060] Embodiment 2: the preparation method of sea cucumber saponin

[0061] 1. The dried sea cucumbers purchased in the market were dried overnight in an oven at 80°C and crushed to 20 meshes.

[0062] 2. Weigh 1 kg of sea cucumber powder, add 5 L of 60% ethanol solution, and extract under reflux at 80°C for 2 hours.

[0063] 3. Recover the filtrate, centrifuge the filtrate at 5000r / min for 15min, and keep the supernatant; then add 3L of 60% ethanol solution to the sea cucumber dregs, carry out heat reflux extraction under the same conditions as above, collect the supernatant this time, and combine the supernatant obtained twice . This process consumes a total of 10L of 60% ethanol solution.

[0064] 4. Concentrate the obtained supernatant by vacuum rotary evaporation (50° C.), remove the ethanol component therein, and obtain a liquid extract.

[0065] 5. Add water to dissolve the extract to make an aqueous solution, add the sample to HP-20 macroporous resin, after absorbi...

Embodiment 3

[0068] Embodiment 3: Slimming capsules with sea cucumber saponin as the main component

[0069] The sea cucumber saponin in the embodiment of the present invention is a functional component. According to the conventional preparation process, sea cucumber saponin can be used as the main functional component, and conventional excipients, disintegrants, binders, solubilizers and other auxiliary materials can be added to prepare Formed into tablets, capsules, etc.

[0070] Raw material: sea cucumber saponin 100g, micropowder silica gel 20g, dextrin 400g, starch 480g

[0071] Add the above ingredients into a blender, stir and mix well, then fill capsules, each 1g, can be made into 1000 capsules. Each capsule contains 100mg of active ingredient sea cucumber saponin. Take 1 capsule each time, 2 times a day.

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Abstract

The invention discloses a sea cucumber saponin, a preparation method thereof and the application thereof in food or medicines. A sea cucumber saponin mixture comprises multiple sea cucumber alkyl-type triterpenoid saponins. Preferentially, the sea cucumber saponin mixture comprises holothurin A and / or echinoside A. The sea cucumber saponin mixture can also comprise one or more in holothurin A, holothurin B, echinoside A, echinoside B, 24-dehydroechinoside A and stichoposide E. The sea cucumber saponin can be applied to preparing weight-losing food or medicines, and animal experimental resultsshow that the sea cucumber saponin can be used for remarkably inhibiting weight increment and reducing internal fat accumulation so as to realize a good weight-losing effect. The preparation method of the sea cucumber saponin is low in cost, simpler in steps and less in the pollution of organic solvents on the environment; and through animal experiments, the prepared sea cucumber saponin is proved to have a good weight-losing effect so as to be used for developing safe and effective weight-losing food or medicines.

Description

technical field [0001] The invention relates to the technical field of functional food and medicine, its preparation method and application, in particular to a preparation method of sea cucumber saponin and its application in the preparation of diet food or medicine. Background technique [0002] Overweight or obesity refers to the pathological state of excessive fat components caused by various reasons and exceeding the average amount of normal people. The World Health Organization defines overweight as a body mass index (BMI) ≥ 25kg / m 2 , obesity is BMI ≥ 30kg / m 2 . Combined with the characteristics of the Asian population, China defines overweight as BMI ≥ 24kg / m 2 , obesity is BMI ≥ 28kg / m 2 . With the change of people's eating structure and living habits, obesity is becoming more and more common. At first, people thought that obesity was simply caused by overeating, and they didn't know enough about its harm, so they didn't regard it as a disease. Studies in recen...

Claims

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Application Information

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IPC IPC(8): A23L1/29A23L1/30A61K35/56A61P3/04A23L33/00A61K35/616
Inventor 王玉明胡晓倩董平薛勇李兆杰王静凤唐庆娟薛长湖
Owner OCEAN UNIV OF CHINA
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