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Application of ursane type triterpenoid saponin in the preparing process of leucocyte and/or platelet increasing medicine

A triterpene saponin and ursane-type technology, which can be used in drug combinations, extracellular fluid diseases, blood diseases, etc., can solve problems such as increasing the activity of human white blood cells and platelets

Inactive Publication Date: 2005-03-16
CHENGDU DIAO PHARMA GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far, there are no relevant literature records or research reports about ursane-type triterpene saponins and their derivatives that can increase the activity of human leukocytes and platelets.

Method used

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  • Application of ursane type triterpenoid saponin in the preparing process of leucocyte and/or platelet increasing medicine
  • Application of ursane type triterpenoid saponin in the preparing process of leucocyte and/or platelet increasing medicine
  • Application of ursane type triterpenoid saponin in the preparing process of leucocyte and/or platelet increasing medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Example 1: Extraction, separation and structure confirmation of ursane-type triterpene saponin compounds A, B, and C

[0041] Extraction and separation: Sanguisorba officinalis L. was purchased from Chengdu Traditional Chinese Medicine Company and identified as Sanguisorba officinalis L. Take 20kg of Burnet herb, cut into slices, extract twice with 8 times the amount of 70% ethanol, each time for 1 hour, filter, recover the ethanol, add water to 0.3g crude drug / ml, refrigerate for 12 hours, take the supernatant and absorb it through the macropores resin. Wash with water until the Molish reaction is negative, then elute with 70% ethanol, collect the eluate, recover ethanol, and concentrate to obtain a thick extract. Add 25L of hot water to the concentrated extract and stir thoroughly, and filter out the precipitate (about 4kg, mainly tannins detected by TLC). The filtrate was extracted three times with equal volumes of ethyl acetate and n-butanol respectively, then con...

Embodiment 2

[0044] Embodiment 2: ursane type triterpene saponin compounds A, B, C, D, E, F, G, H

[0045] Therapeutic effect on cyclophosphamide-induced leukopenia and thrombocytopenia in mice

[0046] Materials and Methods

[0047] Test drug: the three samples of compound A, B, and C are all off-white powder or crushed crystals, prepared according to the method of Example 1, and can also be separated, identified and prepared with reference to the literature [Triterpene glycosides from the roots Sanguisorba officindis, Phytochenistry, 57 (5), 773-779, 2001]; Compounds D, E, and F were isolated, identified and prepared by referring to the literature [Triterpene glycosides from the roots Sanguisorba officindis, Phytochenistry, 57(5), 773-779, 2001]. Compound G was isolated, identified and prepared by referring to the literature [phytochemistry, 26(7), 2023, 1987; Chen.pharm.Bull.35(2), 524, 1987]. Compound H was isolated, identified and prepared according to the literature [phyto...

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PUM

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Abstract

The invention discloses the use of ursane type triterpenoid saponin in preparing medicine for increasing leucocyte and / or platelet which has a general formula (I), the invention also provides a pharmaceutical composition having the action of increasing human leucocyte and / or platelet, which contains ursane type triterpenoid saponin composition having a general formula (I), and pharmaceutically acceptable salts.

Description

Technical field: [0001] The present invention relates to a new use of a compound, in particular to the use of an ursane-type triterpene saponin compound in the preparation of medicines for preventing or treating human leukopenia and (or) thrombocytopenia. Background technique: [0002] Human leukopenia is a common clinical disease and frequently-occurring disease. Generally, chronic leukopenia has no special symptoms, but some patients may experience mild fatigue, dizziness, low-grade fever, and oral ulcers. When leukopenia is severe, various infections can occur, such as respiratory tract infection, bronchitis, pneumonia, otitis media, and urinary system infection. There are many factors that cause leukopenia, and the common ones include the following aspects: First, leukopenia caused by various therapeutic drugs, such as tumor chemotherapy drugs, antipyretic analgesics, sulfa drugs, antithyroid drugs, and antiallergic drugs. It may cause leukopenia in human body; secondly...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61P7/00
Inventor 邹文俊刘忠荣李伯刚付铁军黄瑜丁立生彭树林
Owner CHENGDU DIAO PHARMA GROUP
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