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Drug-carrying nanofibers and preparation method and application thereof

A drug-loaded nanometer and nanofiber technology, which is applied in the fields of pharmaceutical formulations, fiber chemical characteristics, cellulose/protein conjugated artificial filaments, etc., can solve the problem of ineffective scar inhibition, inability to produce large-scale applications, and low preparation efficiency. problem, to achieve the effect of inhibiting the formation and growth of scar, regulating growth and proliferation behavior, and simple process

Active Publication Date: 2019-12-10
GUILIN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

With lactic acid / glycolic acid copolymer (PLGA) as the shell, polycaprolactone (PCL) loaded asiaticoside (C48H78O19) as the inner core, the core / shell structure drug-loaded nanofibers were prepared by coaxial electrospinning, and it was disclosed that the drug-loaded nanofibers with asiaticoside as the inner core had a good healing effect, but inhibited scarring. The effect is not obvious, and it is difficult to obtain continuous and uniform core / shell structure composite nanofibers due to coaxial electrospinning, and the preparation efficiency of the preparation device is low, which cannot be used in large-scale production
Moreover, there is no specific study on how to improve the effect of inhibiting scars by using another extract of Centella Asiatica, Asiatic acid, as an active component.

Method used

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  • Drug-carrying nanofibers and preparation method and application thereof
  • Drug-carrying nanofibers and preparation method and application thereof
  • Drug-carrying nanofibers and preparation method and application thereof

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Embodiment approach

[0031] According to a specific embodiment of the present invention, the drug-loaded nanofiber of the present invention is a product obtained by (blending) electrospinning, that is, all components are mixed and prepared to obtain a mixed spinning solution and then obtained by electrospinning A collection of drug-loaded nanofibers with a nanofibrous structure (drug-loaded nanofiber dressing).

[0032] In a second aspect, the present invention provides a method for preparing drug-loaded nanofibers, the preparation method comprising: electrospinning a spinning solution containing asiatic acid and auxiliary components to obtain drug-loaded nanofibers.

[0033]In the present invention, the electrospinning is a blended electrospinning method, and the conditions of the blended electrospinning method are not particularly limited, and can be conventionally selected in the field. Preferably, the electrospinning conditions make the single filament diameter of the drug-loaded nanofibers 80...

Embodiment 1

[0070] Polycaprolactone was dissolved in a mixed solvent of acetic acid / anhydrous formic acid (volume ratio 3:1) to prepare a solution with a concentration of 20% by weight. The gelatin was dissolved in a mixed solvent of acetic acid / anhydrous formic acid (volume ratio 3:1) to prepare a solution with a concentration of 8% by weight. Polycaprolactone solution and gelatin solution were mixed according to the mass ratio of 9:1 to obtain a mixed solution, magnetically stirred for 2 h, and 2% by weight of Asiatic acid was added (that is, with respect to 100 g of polycaprolactone and gelatin solute, 2 g of product Madecasic acid), magnetically stirred for 1h to obtain polycaprolactone / gelatin / asiatic acid spinning solution, which was a homogeneous mixed solution. The resulting spinning solution was ultrasonically degassed (at 35° C. for 10 minutes, the same below), and then electrospun, and the drug-loaded nanofiber membrane was collected on aluminum foil for 24 hours. The spinning...

Embodiment 2

[0076] Polycaprolactone was dissolved in a mixed solvent of acetic acid / anhydrous formic acid (volume ratio 2:1) to prepare a solution with a concentration of 22% by weight. The gelatin was dissolved in a mixed solvent of acetic acid / anhydrous formic acid (volume ratio 4:1) to prepare a solution with a concentration of 7% by weight. Polycaprolactone solution and gelatin solution were mixed according to the mass ratio of 6:1 to obtain a mixed solution, magnetically stirred for 2h, and 5% by weight of Asiatic acid was added (that is, relative to 100g of polycaprolactone and gelatin solute, 5g of product Madecasic acid), magnetically stirred for 1h to obtain polycaprolactone / gelatin / asiatic acid spinning solution, which was a homogeneous mixed solution. After the obtained spinning solution was ultrasonically degassed, electrospinning was performed, and the drug-loaded nanofiber membrane was collected on aluminum foil for 24 hours. The spinning conditions are as follows: power su...

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Abstract

The invention relates to skin external products, in particular to drug-carrying nanofibers and a preparation method and application thereof. The drug-carrying nanofibers contain nanofiber bodies and asiatic acid, wherein the nanofiber bodies are formed by auxiliary components, and asiatic acid is loaded on the nanofiber bodies; and relative to each gram of asiatic acid, the content of the auxiliary components is 5-75 g. The preparation method of the drug-carrying nanofibers includes the steps: a spinning solution containing asiatic acid and the auxiliary components is subjected to electrostatic spinning to obtain the drug carrying nanofibers. The application of the drug-carrying nanofibers for preparing scar-inhibiting skin external products is also disclosed. According to the drug-carrying nanofibers, asiatic acid serves as an active component, the efficacy of the active component is released continuously, therefore, healing is promoted, inflammation is diminished, growth and proliferation behaviors of cells are adjusted, then, growth and development of scars are effectively inhibited, and accordingly the drug-carrying nanofibers can be widely applied to the skin external products, especially to dressings. A blending electrostatic spinning method is adopted to prepare the drug carrying nanofibers, a preparation technology is simple, and the prepared drug-carrying nanofibers are continuous and uniform.

Description

technical field [0001] The present invention relates to external skin products, in particular to drug-loaded nanofibers and their preparation methods and applications. Background technique [0002] Keloid, commonly known as keloid, is a skin collagen disease characterized by excessive deposition of collagen in the dermis and subcutaneous tissue secondary to skin injury such as trauma, burns or surgery, which is caused by abnormal accumulation of collagen after skin injury Excessive scarring. Different from hypertrophic scar, it is characterized by excessive growth, beyond the boundary of the original wound, invading adjacent tissues, showing tumor-like hyperplasia, causing dysfunction, with a predilection site, more common in people of color, no degenerative changes and after simple surgical resection Very easy to relapse and so on. Keloid is a very difficult medical problem faced by surgery, especially plastic surgery. Keloids are raised from the skin surface, hard and t...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K47/34A61K47/42A61K31/56A61P17/02A61L15/20A61L15/26A61L15/32A61L15/44D01F8/14D01F8/02D01F1/10
CPCA61K9/7007A61K47/34A61K47/42A61K31/56A61P17/02A61L15/20A61L15/26A61L15/325A61L15/44D01F8/14D01F8/02D01F1/10A61L2300/412A61L2300/41A61L2300/21A61L2300/602C08L67/04
Inventor 蒋志敏李迎迎段小群张可锋韦日明陈智梅卢燕兰李美月
Owner GUILIN MEDICAL UNIVERSITY
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