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Use of asiatic acid in preparing medicine

A kind of asiatic acid, a technology for preparing medicine, applied in the field of medicine preparation of asiatic acid, can solve problems such as unreported

Inactive Publication Date: 2007-04-11
THE FIRST PEOPLES HOSPITAL OF FOSHAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The use of asiatic acid in the preparation of anti-hepatic fibrosis drugs has not been reported so far

Method used

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  • Use of asiatic acid in preparing medicine
  • Use of asiatic acid in preparing medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Asiatic acid acts on rat hepatic stellate cells, prepares protein samples, Western blot:

[0049] 1. HSC-T6 cells 1×10 4 Spread 6-well plates, 5% CO 2 , 37°C, after 24 hours, add asiatic acid (purchased from SIGMA, USA) at concentrations of 5 μM, 10 μM, 20 μM, and 30 μM, add TGFβ 1 ng / ml after 2 hours, continue to cultivate for 24 hours, and extract cell protein by conventional methods. For protein content determination, store at -70°C for later use or do Western blot directly.

[0050] 2. The Western blot method is completely based on the second edition of "Molecular Cloning Experiment Guide" translated by Jin Dongyan, Li Mengfeng, etc. See pages 880-885 for protein acrylamide gel electrophoresis, and see pages 888-893 for protein transfer from SDS acrylamide gels to PVDF membranes.

[0051] 3. Wash the membrane with TBST after transfer. Block with 5% skimmed milk powder-TBST blocking solution at room temperature for 60 min; wash the membrane with TBST. Add the pr...

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Abstract

The new use of astatic acid in manufacturing drugs is disclosed, particularly the use in the aspect of manufacturing drugs for anti hepatic fibrosis.

Description

technical field [0001] The invention relates to the use of asiatic acid in the preparation of medicines, in particular to the use of asiatic acid in the preparation of anti-hepatic fibrosis medicines. Background technique [0002] Centella asiatica is a plant of the genus Centella asiatica, which is widely distributed in the south of the Yangtze River Basin. The whole herb is used as medicine. Centella asiatica has a history of more than 2,000 years in my country for its external and oral administration. It has the functions of clearing away heat and dampness, detoxifying and reducing swelling. It is suitable for damp-heat jaundice, heatstroke and diarrhea, sand and blood, carbuncle and sore, and injury from falls. [0003] The chemical composition of Centella asiatica is mainly triterpenoids, such as pentacyclic triterpene ester glycosides such as asiaticoside and madecassoside. Centella asiatica also contains triterpenoid acids, such as asiatic acid, madecassic acid an...

Claims

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Application Information

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IPC IPC(8): A61K31/56A61P1/16
Inventor 谭家驹汤丽霞杨光蓝辉耀
Owner THE FIRST PEOPLES HOSPITAL OF FOSHAN
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