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Application in antidepressants preparation of asiatic acid and derivative

A technology of asiatic acid and derivatives, which is applied in the directions of drug combinations, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problems of asiatic acid antidepressant drugs, etc., and achieve obvious antidepressant effect and chemical A stable effect

Inactive Publication Date: 2006-05-17
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far there is no report that asiatic acid and its derivatives are used for the preparation of antidepressant drugs

Method used

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  • Application in antidepressants preparation of asiatic acid and derivative
  • Application in antidepressants preparation of asiatic acid and derivative

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment 1, the preparation of Centella asiatica total aglycon tablet

[0032] prescription:

[0033] Centella asiatica total aglycon 30g

[0034] Starch 30g

[0035] Lactose 40g

[0036] Sodium carboxymethyl starch 5g

[0037] Appropriate amount of starch slurry (7%)

[0038] Magnesium Stearate 1% (1.25g)

[0039] Made into 1000 pieces

[0040] Process:

[0041]Take the total aglycone of centella asiatica in the prescribed amount, crush it through a 100-mesh sieve, then crush the starch and lactose in the prescribed amount through a 100-mesh sieve, and mix well. Add asiatic acid and sodium starch glycolate to the mixed starch and lactose, and mix well. Add an appropriate amount of 7% starch slurry and mix well, granulate through a 16-mesh wire mesh, dry below 60°C, granulate, add an appropriate amount of magnesium stearate, mix evenly, analyze the content and then compress into tablets. It can be made into 1000 tablets each containing 30mg t...

Embodiment 2

[0042] Embodiment 2, the preparation of asiatic acid capsules

[0043] prescription:

[0044] Asiatic acid 30g

[0045] Starch 160g

[0046] Starch silica gel 10g

[0047] Make 1000 capsules

[0048] Process:

[0049] Take the prescribed amount of asiatic acid, crush through a 100-mesh sieve, add the prescribed amount of starch and starch silica gel, mix well, and directly pack into capsules to make 1000 capsules each containing 30 mg of asiatic acid.

Embodiment 3

[0050] Embodiment 3, the preparation of Sodium Asiatica Acid Injection

[0051] prescription:

[0052] Sodium asiaticate 10g

[0053] Ethanol (95%) 4000g

[0054] Propylene glycol (C.P.) 1000g

[0055] Add water for injection to 10000ml

[0056] Make 1000 pieces

[0057] Process:

[0058] Take 5000g of ethanol (95%) at 20°C, add 5g of activated carbon and stir, filter under reduced pressure through a sand core set, and set aside. Add the prescription amount of sodium asiaticate to 4000g of the above-mentioned ethanol, heat to about 50°C, stir well to make it dissolve and clear, then add the prescription amount of propylene glycol, and then add fresh water for injection to make the total amount 10000ml, stir well, mix well, add Activated carbon 3g, through the sand core group decompression filtration clarification, combined filtrate before and after, and then fine filtration clarification with special sand core. After checking the content and clarity, i...

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Abstract

The invention relates to the new application of asiatic acid and its derivatives in the preparation of antidepressants. Experiments have proved that asiatic acid and its derivatives, as well as the pharmaceutical composition, are safe, efficient, stable, and cheap drugs for preventing and treating depression, all of which have relatively high activity, especially asiatic acid, centella asiatica Compounds such as sodium oxalate are more active than doxepin.

Description

technical field [0001] The present invention relates to a new application of ursane-type pentacyclic triterpenes, in particular to a new application of Asiatic acid and its derivatives, more specifically to the use of Asiatic acid and its derivatives in the preparation of antidepressants New uses in . Background technique [0002] Affective mental disorder, one of the five major diseases that endanger human health in the world today, has brought a heavy burden to human society. Depression in affective disorders is a group of diseases characterized by significant and persistent depression, behavioral rigidity and pessimistic world-weariness. It's so common, in fact, that it's been called the "common cold" of mental illness, and it's also a serious, life-threatening illness that afflicts tens of millions of people around the world. Therefore, there is an urgent need for safe, efficient and inexpensive antidepressants. [0003] The drugs currently used to treat depression ma...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/56A61P25/28
Inventor 李铁军陆波邱彦毛俊琴徐亚敏芮耀诚
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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