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Asiatic acid salt hard capsule and preparation method thereof

A hard capsule and oxalate technology, which can be used in capsule delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc., and can solve the problems of unsatisfactory efficacy and low bioavailability of asiatic acid and its salt hard capsules , to achieve broad market prospects and practical value, good quality stability, and not brittle

Inactive Publication Date: 2012-10-31
SHANGHAI INST OF PHARMA IND CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The technical problem to be solved by the present invention is to overcome the defects that the existing asiatic acid and its salt hard capsules have unsatisfactory drug efficacy and extremely low bioavailability, and provide a kind of asiatic acid salt with good bioavailability Hard capsule and preparation method thereof

Method used

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  • Asiatic acid salt hard capsule and preparation method thereof
  • Asiatic acid salt hard capsule and preparation method thereof
  • Asiatic acid salt hard capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026]

[0027] Preparation method: according to the formula in the above table, mix the medicine and auxiliary materials, and fill them into the capsule shell.

[0028] After testing (rat tail vein injection method, see "Journal of Southern Medical University" 2009 Issue 06), the bioavailability of the obtained hard capsule asiatic acid tromethamine salt is 22.6%.

Embodiment 2

[0030]

[0031] Preparation method: according to the formula in the above table, mix the drug and auxiliary materials, granulate, and fill into the capsule shell.

Embodiment 3

[0033]

[0034] Preparation method: according to the formula in the above table, mix the medicine and auxiliary materials, and fill them into the capsule shell.

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PUM

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Abstract

The invention discloses an asiatic acid salt hard capsule and a preparation method thereof. An asiatic acid salt hard capsule formula comprises 5-40 percent of an asiatic acid amino butantriol salt, 50-95 percent of a filling agent, 0-10 percent of a lubricating agent and 0-2.0 percent of an adhesive, wherein the percentage refers to the mass percentage of each component in the total amount of asiatic acid salt hard capsule contents. The method comprises the following steps of: uniformly mixing the raw materials according to a formula; and filling into the conventional hard capsule shell. The asiatic acid salt hard capsule disclosed by the invention has high bioavailability.

Description

technical field [0001] The invention relates to a hard capsule of asiatic acid salt and a preparation method thereof. Background technique [0002] It is reported in the prior art that asiatic acid and its salts can prevent and treat fibrosis diseases of some internal organs, but the drug effect of the related hard capsules is not ideal, and the bioavailability is extremely low. In order to maximize the effective utilization of the drug, this The status quo needs to be resolved urgently. Contents of the invention [0003] The technical problem to be solved by the present invention is to overcome the defects that the existing asiatic acid and its salt hard capsules have unsatisfactory drug efficacy and extremely low bioavailability, and provide a kind of asiatic acid salt with good bioavailability Hard capsule and its preparation method. [0004] The hard capsule formulation of asiatic acid salt of the present invention contains 5% to 40% asiatic acid tromethamine salt, 5...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/56A61K9/48
Inventor 刘英刘全海张瑱虞丽芳陈志祥肖璘蔡立吴学军金立玲邓轶方
Owner SHANGHAI INST OF PHARMA IND CO LTD
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