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Pharmaceutical composition for treating leuconychia

A composition and a technology for onychomycosis are applied in the field of a pharmaceutical composition for treating onychomycosis and a vesicle solution for treating onychomycosis, and can solve the problems of large dosage, insignificant effect of external coating, long medication time and the like.

Active Publication Date: 2015-12-30
CHANGSHA BAISHUN BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since this type of drug must reach the deck where the fungus parasitizes to exert its antibacterial effect, the dosage is large and the medication time is long, so the adverse drug reactions should be monitored regularly
For external use, according to different medicaments, the main methods are local application and packet cutting, such as terbinafine tincture, amorolfine A liniment, ciclopirox ketone A varnish and other antifungal topical application, but due to The drug permeability is poor, and the effect of external application is not obvious

Method used

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  • Pharmaceutical composition for treating leuconychia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Terbinafine 1g

[0021] Bifonazole 1g

[0022] Span 4025g

[0023] Tween 8015g

[0024] Cholesterol 8g

[0025] Sodium cholate 12g

[0026] Add purified water to 100g

[0027] Preparation:

[0028] 1) Dissolve the prescription amount of terbinafine, bifonazole and capsule material in chloroform;

[0029] 2) Short-term ultrasonication forms a stable emulsion, and then removes the organic solvent by rotary evaporation under reduced pressure. After reaching a colloidal state, add the prescribed amount of hydration medium at 45°C for 1 hour of hydration, and then ultrasonically treat in an ice bath.

Embodiment 2

[0031] Terbinafine 1g

[0032] Bifonazole 1g

[0033] Span 4020g

[0034] Tween 8025g

[0035] Cholesterol 10g

[0036] Sodium cholate 10g

[0037] Add purified water to 100g

[0038] Preparation:

[0039] 1) Dissolve the prescription amount of terbinafine, bifonazole and capsule material in chloroform;

[0040] 2) Short-term ultrasonication forms a stable emulsion, and then removes the organic solvent by rotary evaporation under reduced pressure. After reaching the colloidal state, add the prescribed amount of hydration medium and hydrate at 45°C for 1 hour, and then ultrasonically treat it in an ice bath.

Embodiment 3

[0042] Terbinafine 2g

[0043] Bifonazole 1g

[0044] Span 4020g

[0045] Tween 8025g

[0046] Cholesterol 8g

[0047] Sodium cholate 10g

[0048] Add purified water to 100g

[0049] Preparation:

[0050] 1) Dissolve the prescription amount of terbinafine, bifonazole and capsule material in chloroform;

[0051] 2) Short-term ultrasonication forms a stable emulsion, and then removes the organic solvent by rotary evaporation under reduced pressure. After reaching the colloidal state, add the prescribed amount of hydration medium and hydrate at 45°C for 1 hour, and then ultrasonically treat it in an ice bath.

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PUM

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Abstract

The invention provides a pharmaceutical composition for treating leuconychia. The pharmaceutical composition is prepared from the following raw materials in parts by weight: 1-15 parts of an active component terbinafine, 1-15 parts of bifonazole, 15-60 parts of a capsule wall material, 5-50 parts of a hydration medium and 10-80 parts of purified water. The prepared pharmaceutical composition for treating leuconychia is high in vesicle solution encapsulation efficiency, high in permeation rate, fast to act, safe and reliable, and has a market development prospect; and the problem that fungi attached to a nail plate of a leuconychia patient cannot be killed due to thick cornifin is solved.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations and relates to a pharmaceutical composition for treating onychomycosis. The invention also provides a vesicle solution for treating onychomycosis with safe quality and quick effect. Background technique [0002] Onychomycosis, scientific name onychomycosis, is the nail infection that is caused by fungi such as dermatophyte, yeast and non-dermatophyte. It is often caused by various fungi such as Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton flocculum. A few are caused by other filamentous fungi, yeast-like bacteria and yeasts, and occasionally by sporozoites, Fusarium and Aspergillus terrescens. [0003] At present, the treatment is based on oral administration and external application. Oral administration such as oral administration of terbinafine tablets 250 mg per day for 6 to 12 weeks; itraconazole 400 mg / day for 7 days and rest for 21 days as a cour...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/127A61K31/4174A61P31/10A61P17/00A61K31/137
Inventor 卢洪成其他发明人请求不公开姓名
Owner CHANGSHA BAISHUN BIOTECH
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