Medicine composition for treating skin diseases as well as preparation method and application thereof

A composition and skin disease technology, applied in the field of pharmaceutical compositions for the treatment of skin diseases, can solve the problems of cumbersome and complicated compound ingredients, unfavorable large-scale preparation, etc., and achieve the goals of wide application range, quick treatment effect, and reduced drug cost Effect

Inactive Publication Date: 2015-04-29
CHENGDU QIANKUN VETERINARY PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, its complex composition is not conducive to large-scale preparation
At the same time, the medicine needs to be applied twice a day for 14 consecutive days, and a medicated bath is required every week, which is very cumbersome and complicated
[0011] However, there is currently no drug that simultaneously includes doramectin and terbinafine, and can easily and effectively treat skin diseases.

Method used

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  • Medicine composition for treating skin diseases as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] The tablet preparation of embodiment 1 pharmaceutical composition of the present invention

[0032] The raw materials used are:

[0033] Doramectin 1g

[0034] Terbinafine 1g

[0035] Microcrystalline Cellulose 98g

[0036] A total of 200 tablets

[0037] Preparation method: Mix 1g of doramectin, 1g of terbinafine and 98g of microcrystalline cellulose evenly, and then directly compress into tablets by dry method, making a total of 200 tablets, each weighing 0.5g.

Embodiment 2

[0038] The spray preparation of embodiment 2 pharmaceutical compositions of the present invention

[0039] The raw materials used are:

[0040] Doramectin 1g

[0041] Terbinafine 1.5g

[0042] Ethylparaben 0.2g

[0043] Butylparaben 0.1g

[0044] Propylene glycol 80g

[0045] Add ethanol to 100g

[0046] Preparation method: Dissolve 1g doramectin and 0.5g terbinafine in 80g propylene glycol, add 0.2g ethylparaben and 0.1g butylparaben, add ethanol to prepare 100g solution, and pack in Available in a spray bottle.

Embodiment 3

[0047] The ointment preparation of embodiment 3 pharmaceutical composition of the present invention

[0048] The raw materials used are:

[0049] Doramectin 1g

[0050] Terbinafine 2g

[0051] Appropriate amount of vegetable oil

[0052] Beeswax 20g

[0053] Lanolin 17g

[0054] Ethylparaben 0.2g

[0055] Butylparaben 0.1g

[0056] Total 100g

[0057] Preparation method: Dissolve 1g doramectin and 2g terbinafine in 50g hot vegetable oil, then add 20g beeswax, 17g lanolin in sequence, finally add 0.2g ethylparaben and 0.1g butylparaben, add The remaining vegetable oil is made into 100g, mixed evenly with a ball mill, and then distributed for use.

[0058] In order to prove the beneficial effect of the pharmaceutical composition of the present invention, the following test examples are provided.

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Abstract

The invention discloses a medicine composition for treating skin diseases. The medicine composition contains the following raw material medicines in parts by weight: 1 part of doramectin and 1-2 parts of terbinafine. The invention further provides a preparation method for the medicine composition and an application of the medicine composition in preparation for a medicine for treating skin diseases. Pharmacological experiments indicate that the medicine composition disclosed by the invention is safe and free from toxic and side effects, fast to become effective and high in effective rate, low in medication dose and low in administration frequency, as well as wide in selective dosage forms, simple in administration mode, and suitable for large-scale clinic popularization and application.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating skin diseases, in particular to a pharmaceutical composition comprising doramectin and terbinafine components, the invention also relates to a preparation method of the pharmaceutical composition and its preparation and treatment Use in medicine for skin diseases. Background technique [0002] Skin disease is a common disease of humans and animals, which not only seriously threatens human health, but also brings huge economic losses to the production of animal husbandry. Among them, especially the skin diseases caused by parasites and fungi, because the clinical symptoms of the two are similar, it is generally difficult to distinguish them for targeted treatment, and mixed infections often occur clinically, which brings great difficulties to cure. For the treatment of this mixed infection, the current common method is to use antiparasitic and antifungal drugs alternately or simultaneou...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P17/00A61P31/10A61P33/14A61P33/10A61K31/137
CPCA61K31/7048A61K31/137A61K2300/00
Inventor 唐华侨李超杨海涵余琴
Owner CHENGDU QIANKUN VETERINARY PHARMA
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